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Symptom
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Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
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Query: UMLS:C0015674 (
chronic fatigue syndrome
)
2,978
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The pathogenesis of
chronic fatigue syndrome
(
CFS
) is unknown but one of the most characteristic features of the illness is fluctuation in symptoms which can be induced by physical and/or mental stress. Other conditions in which fluctuating fatigue occurs are caused by abnormal ion channels in the cell membrane. These include genetically determined channelopathies, e.g. hypokalemic periodic paralysis, episodic ataxia type 2 and acquired conditions such as neuromyotonia, myasthenic syndromes, multiple sclerosis and inflammatory demyelinating polyneuropathies. Our hypothesis is that abnormal ion channel function underlies the symptoms of
CFS
and this is supported also by the finding of abnormal cardiac-thallium201 SPECT scans in
CFS
, similar to that found in
syndrome X
, another disorder of ion channels.
CFS
and
syndrome X
can have identical clinical symptoms.
CFS
may begin after exposure to specific toxins which are known to produce abnormal sodium ion channels. Finally, in
CFS
, increased resting energy expenditure (REE) occurs, a state influenced by transmembrane ion transport. The hypothesis that ion channels are abnormal in
CFS
may help to explain the fluctuating fatigue and other symptoms.
...
PMID:The symptoms of chronic fatigue syndrome are related to abnormal ion channel function. 1109 Mar 4
