Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0015674 (
chronic fatigue syndrome
)
2,978
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Depressed mood and the psychiatric diagnosis of major depressive episode (MDE) are common findings in patients with
chronic fatigue syndrome
(
CFS
). The relationship between depression and
CFS
is unclear and may be explained by one of four models: (1)
CFS
is an atypical manifestation of MDE; (2) depression is the result of
CFS
as either an organic mood syndrome or an
adjustment reaction
; (3)
CFS
and MDE are covariates; and (4) the diagnosis of MDE is artifactual. The evidence for these models is discussed. The potentially confounding effect of depression on tests of immune function and neuropsychological testing is described. The implications of these different models for the design of studies of
CFS
are examined.
...
PMID:Chronic fatigue syndrome and depression: cause, effect, or covariate. 202 Aug 5
