Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 3174
She 872
hemoglobin 569
insulin 546
ATP 545
interferon 473
cytokine 432
creatine kinase 402
MRI 363
Mol 358
ANOVA 324
C-reactive protein 271
C30 259
IL-6 235
collagen 224
lactate dehydrogenase 222
IFN 212
tumor necrosis factor 190
ATPase 186
alkaline phosphatase 184
Mot 178
tyrosine kinase 171
TNF 171
myosin 169
CO2 168
SARS 161
erythropoietin 160
CD4 157
interleukin-6 155
myosin heavy chain 151
ACS 149
growth hormone 149
alanine aminotransferase 147
aspartate aminotransferase 146
ADP 142
gut 141
axonal 134
albumin 134
cage 133
superoxide dismutase 130
sit 129
Gen 123
leptin 122
ACTH 118
ferritin 113
prolactin 109
interferon-alpha 102
beta-endorphin 100
Men 99
vascular endothelial growth factor 99
Pol 97
COPD 96
hole 93
AMP 93
LDH 91
CRP 90
NMR 89
CD8 88
reserved 85
mTOR 83
renin 82
thyroid hormone 81
fused 81
catalase 79
parathyroid hormone 78
citrate synthase 77
lymphoid 76
RPE 76
IL-10 75
CSF 75
interleukin-2 75
IgA 74
epidermal growth factor receptor 74
chronic renal failure 74
ankylosing spondylitis 73
myoglobin 73
Erythropoietin 72
FDG 72
interferon alpha 70
serum albumin 69
nodal 68
5-hydroxytryptamine 68
GSH 68
IL-1 68
FACT 67
non-Hodgkin's lymphoma 67
CD20 67
Mil 66
adrenocorticotropic hormone 65
B12 65
myeloperoxidase 65
vasopressin 65
acetylcholine receptor 65
AST 64
HER2 62
BRAF 61
granulocyte colony-stimulating factor 60
glutathione peroxidase 60
trip 58
transferrin 57
REM 57
anonymous 56
histone deacetylase 56
HLA 55
granulocyte 54
short form 54
TNF-alpha 54
ESR 53
IL-8 52
PGC 52
Hip 52
dystrophin 52
GABA 50
lipopolysaccharide 50
NADH 50
vascular endothelial growth factor receptor 49
calcium channel 49
Mal 48
VEGF 47
FSS 47
olfactory 46
prostate-specific antigen 46
acetylcholinesterase 46
prothrombin 46
G-CSF 46
ICD 45
beta 1 45
IL-2 45
JAMA 45
glucagon 45
CAD 45
erythroid 44
muscle protein 44
brain-derived neurotrophic factor 44
natriuretic peptide 43
San 43
rheumatoid factor 42
IgE 41
p53 41
interferon-gamma 41
cytochrome P450 41
EDL 41
proteasome 41
CHOP 41
BID 40
MRS 39
phosphodiesterase 39
fibrinogen 38
tumor necrosis factor alpha 38
AMP-activated protein kinase 38
VEGFR2 38
Cytokine 38
ACE 38
P300 38
phosphofructokinase 38
aromatase 38
SOD 37
amylase 37
IGF-1 36
asymmetrical 36
more...
Disease
depression 4534
cancer 4247
tumor 1551
anemia 1529
multiple sclerosis 1151
chronic fatigue syndrome 1078
hypertension 1036
fibromyalgia 905
breast cancer 837
thrombocytopenia 794
neutropenia 792
heart failure 735
rash 698
sleep disturbances 676
diabetes 669
stroke 641
cognitive impairment 640
obesity 613
cold 522
HIV 514
confusion 501
sleep disorders 456
pruritus 454
chronic obstructive pulmonary disease 441
rheumatoid arthritis 434
metastases 419
pneumonia 400
chronic pain 397
AIDS 397
Parkinson's disease 386
lymphoma 364
systemic lupus erythematosus 360
lymphadenopathy 346
arthritis 343
carcinoma 342
leukopenia 337
lung cancer 320
multiple myeloma 314
influenza 311
major depressive disorder 304
chronic disease 289
hypothyroidism 288
psychological distress 286
neuropathy 282
prostate cancer 276
osteoporosis 268
asthma 265
cirrhosis 263
myopathy 261
epilepsy 261
respiratory failure 257
ischemia 256
xerostomia 248
myocardial infarction 246
melanoma 246
cardiovascular disease 244
peripheral neuropathy 243
obstructive sleep apnea 237
hepatitis 236
autoimmune disease 234
congestive heart failure 234
hepatitis C 228
dehydration 227
migraine 226
renal cell carcinoma 225
liver disease 225
colorectal cancer 223
adenocarcinoma 222
leukemia 222
myasthenia gravis 219
sleep apnea 217
virus infection 215
infectious diseases 215
emotional distress 214
SEM 212
mental illness 212
tetanus 207
sexual dysfunction 200
vasculitis 196
non-small cell lung cancer 196
Hodgkin's disease 194
myelosuppression 193
SARS 191
tuberculosis 190
malnutrition 189
dysphagia 188
renal failure 187
chronic hepatitis 186
dementia 185
immunodeficiency 184
proteinuria 178
sepsis 175
acute myeloid leukemia 174
coronary artery disease 173
sarcoidosis 170
hepatocellular carcinoma 170
irritable bowel syndrome 169
hypoglycemia 166
type 2 diabetes 165
lupus 163
adrenal insufficiency 160
stomatitis 157
sepsis 157
osteoarthritis 157
polio 156
Epstein 156
muscular atrophy 155
renal disease 155
gastric cancer 154
psychosis 153
West 151
heart disease 147
psychological stress 147
hyperglycemia 146
metastatic breast cancer 140
pancytopenia 140
myelodysplastic syndrome 138
hypercalcemia 137
anxiety disorders 136
cardiomyopathy 132
Alzheimer's disease 131
ovarian cancer 131
pulmonary hypertension 129
Lyme disease 126
lymphopenia 126
inflammatory bowel disease 124
posttraumatic stress disorder 121
amyotrophic lateral sclerosis 120
endocarditis 120
eosinophilia 120
primary biliary cirrhosis 119
fits 119
hand-foot syndrome 118
Tension 114
Best 114
iron deficiency 112
schizophrenia 112
myocardial ischemia 111
wasting 110
B-cell lymphoma 109
Syndrome 108
hypogonadism 107
metastatic renal cell carcinoma 106
chronic renal failure 104
hepatitis B 103
encephalopathy 102
diplopia 101
cholestasis 100
erectile dysfunction 99
hyperthyroidism 99
acute renal failure 99
prolapse 98
metabolic syndrome 97
incontinence 97
restless legs syndrome 97
COPD 96
rare disease 96
coma 96
infectious mononucleosis 92
chronic lymphocytic leukemia 91
more...
Symptom
fatigue 51768
pain 4991
headache 2476
nausea 2348
dyspnea 1984
weakness 1882
sleepiness 1585
diarrhea 1579
anorexia 1361
vomiting 1282
exhaustion 1281
dizziness 1086
insomnia 990
myalgia 933
cough 900
discomfort 741
abdominal pain 663
discomfort 641
arthralgia 605
Ill 589
constipation 480
shortness of breath 458
seizures 414
chest pain 369
mental fatigue 364
back pain 354
nausea and vomiting 348
chills 332
tremor 308
asthenia 269
anesthesia 260
syncope 246
lethargy 240
night sweats 219
low back pain 212
decreased appetite 212
paresthesia 207
cachexia 201
splenomegaly 198
angina 193
sore throat 182
agitation 180
spasticity 172
ataxia 170
vertigo 167
numbness 165
exertional dyspnea 164
erythema 156
apathy 151
snoring 148
overweight 148
hypercapnia 134
twitching 131
bone pain 131
respiratory distress 126
hepatomegaly 122
hepatosplenomegaly 116
pallor 116
polyuria 106
hunger 103
collapse 100
blurred vision 98
memory loss 93
muscle cramps 92
distraction 90
hot flashes 88
analgesia 86
lightheadedness 85
hypersomnia 84
hot flushes 83
hemoptysis 80
hoarseness 78
neck pain 78
cyanosis 77
flushing 74
bloating 74
muscle stiffness 70
abdominal discomfort 70
tingling 68
tinnitus 66
polydipsia 63
functional recovery 62
dysarthria 60
tachypnea 59
Depressive symptoms 59
spasm 57
regurgitation 57
hypothermia 56
shoulder pain 55
menopausal symptoms 55
stigma 54
epigastric pain 54
rhinorrhea 54
starvation 53
dry eye 53
dystonia 52
orthopnea 50
dry skin 49
nasal congestion 48
wheezing 47
forgetfulness 46
lassitude 46
pelvic pain 45
generalized pain 44
fever of unknown origin 43
cancer pain 43
Wind 42
productive cough 41
eds 41
rigors 41
chest tightness 40
leg pain 40
sneezing 39
paresis 39
ophthalmoplegia 38
bewilderment 38
hopelessness 36
photophobia 35
anosmia 34
Poor sleep 34
hyperoxia 33
body pain 33
limb pain 32
joint stiffness 31
excessive sweating 30
dark urine 30
loss of taste 29
incoordination 28
leg edema 28
Stiffness 27
knee pain 27
presyncope 26
facial pain 26
hip pain 26
myoclonus 25
bradykinesia 25
Fatigability 25
oliguria 24
Cancer Fatigue 24
abnormal gait 24
stomach pain 24
acute stress 23
dysuria 23
tense 23
physical symptom 23
acute pain 22
thinning 22
hypotonia 22
dysesthesia 21
right upper quadrant pain 21
heartburn 21
rales 20
chronic cough 20
feeling tired 20
abdominal cramps 19
throat irritation 19
neck stiffness 19
physical exhaustion 19
motor symptom 18
skin irritation 18
more...
Drug
caffeine 388
Cardiovasc 266
CFS 159
Dermatol 120
Posture 91
CSF 90
ascorbate 72
Asthma 61
vitamin E 56
Docetaxel 53
Modafinil 52
G-CSF 49
NADH 48
IL-2 45
Dial 41
Sorafenib 41
Spectrum 40
CTX 39
Leaf 39
CAM 35
Ginseng 33
Ringer's solution 32
CPT-11 31
Lenalidomide 31
MAP 31
ENT 30
lysine 28
Rituximab 27
PTH 27
ROS 27
Check 27
IFN-gamma 26
TMS 25
Monit 25
DM1 25
Bevacizumab 24
Imatinib 23
Epoetin alfa 22
EE2 22
Bortezomib 22
Nephron 22
Taxol 21
Prednisone 21
citric acid 20
Prednisolone 20
Duloxetine 19
Pemetrexed 19
Epoetin 19
Erlotinib 19
Epoetin alfa 19
MDS 19
Domperidone 19
Gleevec 18
Gabapentin 18
lactose 17
Eculizumab 17
NH3 17
TTC 17
Triad 17
Irinotecan 17
Spectrum 16
nitroglycerin 16
IFN-beta 16
Darbepoetin alfa 16
Diurnal 15
Oxaliplatin 15
Nephron 15
Alanine 15
MRC 14
ADM 14
Everolimus 14
Adriamycin 14
CTC 13
CTC 13
Vorinostat 13
niacin 13
Growth hormone 12
EDR 12
Taxotere 12
Vitamin B12 12
Nebivolol 11
Glutathione 11
CTX 11
Growth hormone 11
Gefitinib 11
Portal 11
Axitinib 11
Methylprednisolone 11
ROC 11
CTX 11
Theophylline 11
Cetuximab 11
Ethanol 10
Leucovorin 10
Clonidine 10
ABC 10
Ipilimumab 10
Salbutamol 10
AZT 10
Ranitidine 10
AZT 10
Vitamin E 10
Tocilizumab 10
ampicillin 10
Atenolol 9
Android 9
Captopril 9
Biopolymers 9
IL-1ra 9
Gel 9
Rizatriptan 9
EPA 9
Herceptin 8
ZnO 8
Glycerol 8
Ixabepilone 8
Histamine 8
TiO2 8
Rufinamide 8
Vinorelbine 8
Frontal 7
Serum albumin 7
Atropine 7
Tuberculin 7
Norplant 7
Filgrastim 7
Simvastatin 7
TAC 7
Dasatinib 7
VCR 7
Pregabalin 7
ALA 7
Depo-Provera 6
Ketoconazole 6
TAK 6
ACT 6
Zonisamide 6
Doxycycline 6
Bifidobacterium 6
Zoledronic acid 6
Imiquimod 6
Vandetanib 6
CPR 6
Fructose 6
Filgrastim 6
Timolol 5
Hydrochlorothiazide 5
Frovatriptan 5
Glucagon 5
RFP 5
Intron A 5
Cilazapril 5
Trabectedin 5
Felodipine 5
Sinemet 5
TES 5
ADR 5
Romidepsin 5
THF 5
DPA 5
more...
Enzyme
creatine kinase 464
alanine aminotransferase 280
ERK 267
lactate dehydrogenase 263
ATPase 239
aspartate aminotransferase 209
alkaline phosphatase 184
superoxide dismutase 155
ACS 149
focal adhesion kinase 107
succinate dehydrogenase 102
peroxidase 101
catalase 95
renin 82
citrate synthase 78
acetylcholinesterase 71
AMP-activated protein kinase 64
AST 64
glutathione peroxidase 62
mitogen-activated protein kinase 62
protein kinase 60
ACE 59
phosphorylase 57
gamma-glutamyl transpeptidase 49
CAD 45
CAD 45
cholinesterase 45
CAD 45
prostate-specific antigen 44
phosphofructokinase 44
proteasome 44
PRE 41
reverse transcriptase 41
phosphodiesterase 39
MTD 33
AMPK 31
pyruvate dehydrogenase 30
MEK 30
AMPK 29
myosin ATPase 28
CPT 28
carbonic anhydrase 28
calcineurin 27
complex I 25
succinic dehydrogenase 25
thromboplastin 24
monoamine oxidase 24
lipase 22
thyroid peroxidase 22
cytochrome oxidase 22
CPT 21
PARP 21
CPT 21
MIP 19
CD10 17
hexokinase 17
xanthine oxidase 17
NOS 17
RNA polymerase 17
collagenase 16
AMP deaminase 16
protein kinase C 16
glycerol-3-phosphate dehydrogenase 16
aldolase 16
NO synthase 16
CYP3A4 15
ATP synthase 15
glycerol-3-phosphate dehydrogenase 15
lysozyme 14
diaphorase 14
elastase 14
transglutaminase 13
MCS 13
glutathione reductase 13
DNA polymerase 13
pyruvate dehydrogenase 13
pyruvate dehydrogenase 13
caspase-3 12
malate dehydrogenase 12
glucose-6-phosphate dehydrogenase 12
transcriptase 12
caspase-1 11
BMT 11
adenosine deaminase 11
HSD 11
MAP 11
trypsin 11
CD13 11
thrombin 10
adenylate kinase 10
ceruloplasmin 10
adenosine deaminase 10
angiotensin-converting enzyme 2 10
histidine decarboxylase 9
glutathione S-transferase 9
indoleamine 2,3-dioxygenase 9
myosin light chain kinase 9
tyrosine hydroxylase 9
NADPH-diaphorase 9
FFT 9
FAST 9
NQO1 9
phosphoinositide 3-kinase 9
CFI 9
pyruvate kinase 9
CaMKII 9
alpha-amylase 9
adenylate cyclase 9
diaphorase 8
thymidylate synthase 8
acid phosphatase 8
tryptophan hydroxylase 8
acyl-CoA dehydrogenase 8
topoisomerase 8
topoisomerase 8
enolase 7
P-glycoprotein 7
farnesyltransferase 7
3-hydroxyacyl-CoA dehydrogenase 7
farnesyltransferase 7
lipoprotein lipase 7
CPR 7
proteinase-3 7
asparaginase 7
ricin 7
GSK 6
aconitase 6
AOR 6
tissue plasminogen activator 6
NADH dehydrogenase 6
BAL 6
NADPH oxidase 6
TOR 6
glyceraldehyde-3-phosphate dehydrogenase 6
PDK1 6
MDP 6
21-hydroxylase 6
phosphoenolpyruvate carboxykinase 6
phosphatidylinositol 3-kinase 6
DNA methyltransferase 5
methylenetetrahydrofolate reductase 5
RNase 5
RNase 5
APC 5
Alternating 5
dihydropyrimidine dehydrogenase 5
luciferase 5
dihydropyrimidine dehydrogenase 5
ribonucleotide reductase 5
glutamate dehydrogenase 5
ribonucleotide reductase 5
methylenetetrahydrofolate reductase 5
3-hydroxyacyl-CoA dehydrogenase 5
glutamate dehydrogenase 5
SDMT 5
choline acetyltransferase 5
glutamate dehydrogenase 5
papain 5
PAM 5
botulinum neurotoxin 5
more...
Compound
Dec 3586
Clin 3487
oxygen 2064
water 1127
glucose 990
calcium 884
ATP 546
sodium 528
DNA 495
phosphate 476
titanium 413
His 403
caffeine 389
Cardiol 378
CO2 333
creatinine 332
iron 319
potassium 318
nitrogen 282
phosphocreatine 257
urea 246
ammonia 183
TNF 171
acetate 169
hydrogen 166
ADP 161
nickel 161
tryptophan 155
tryptophan 150
tryptophan 149
tryptophan 149
ACS 149
nitric oxide 149
ACS 149
aluminum 147
DSM 143
ADP 142
ADP 142
salt 127
glutamate 125
5-HT 122
ethanol 121
vitamin D 120
noradrenaline 119
ACTH 112
phosphorus 108
arginine 103
AMP 99
Lactate 97
alanine 94
cobalt 94
tyrosine 92
zinc 83
glutamine 83
glycerol 81
sulfate 80
GSH 76
GSH 76
Thyroid 75
galactose 74
TSH 73
L-carnitine 72
copper 72
Piper 72
Cortisol 71
aldosterone 68
iodine 67
5-FU 66
chromium 64
leucine 63
Optimal 62
PEG 61
silicon 57
mercury 56
Testosterone 54
methionine 54
silver 53
Testosterone 53
carbonate 52
GABA 51
GABA 51
Glycogen 50
N-acetylcysteine 50
NH2 49
bromide 49
Mg2+ 48
CAM 48
Neo 48
NADH 48
nitrate 47
Docetaxel 47
coenzyme Q10 45
DHA 42
Insulin 42
Dial 41
Pac 41
barium 39
A 3 39
Hemoglobin 39
CTX 39
A 71 38
6-12 38
Creatine 37
Melatonin 37
cysteine 35
nicotinamide 35
retinoic acid 35
PEG 35
ammonium 34
ANA 33
ANA 33
Androgen 33
GPT 32
cAMP 32
IMP 32
Adriamycin 31
Carbon 31
NAD 31
lysine 31
ANCA 31
DIC 31
tungsten 30
hydroxide 30
PLA 30
CPT-11 30
formaldehyde 30
Diazepam 30
A 42 30
EDS 29
Phe 29
gamma-aminobutyric acid 29
Estrogen 29
valine 29
A 1 29
vinyl 28
toluene 28
serine 27
neopterin 27
selenium 27
Isoproterenol 27
CES 27
phosphoric acid 26
MAP 26
NAD 26
acrylamide 26
Adrenal 26
MEK 26
PAS 25
DBP 25
formaldehyde 25
Theophylline 25
Gemcitabine 25
Carnitine 25
Propranolol 25
proline 25
Gemcitabine 25
threonine 25
Leucovorin 25
Propranolol 25
DBP 25
more...