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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to modelize muscular fatigue, use and depletion of energizing stores are incorporated in the previously elaborated model. The role of muscle glycogen is crucial in sustained muscular contractions. Two patterns of muscular exhaustion are described: one is related to glycogen depletion (S and FR fibres) and the other to an unphysiological drop in ATP concentrations (FF fibres). Thus, the muscle fibre recruitment can be related to its theoretical metabolism of exhaustion. The importance of the muscle lactate level is connected to the glucose entry into the muscle cell and the rigor mortis. Computations have been carried out on a computer DPS 7.
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PMID:Mathematical model of muscular fatigue. Part III. Classification of muscular fibres versus metabolism of exhaustion. 373 54

In order to study muscular fatigue, a mathematical model allowing the simulation of changes of metabolites level and of force during exercise in human muscle is built. It results from the association of two previous models and from the introduction of two parameters (pH and ATP concentration) influencing directly the muscular force and of the fatigability parameter (A) which characterizes the oxidative capacity of a given fibre. Simulations of physiological conditions of exercise and recovery allow one to bring out a classification of muscular fibres in terms of the fatigability parameter. In addition, the study of successive exercises underlines the lactate level role in force generation. Computations have been carried out on a computer DPS 7.
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PMID:Mathematical model of muscular fatigue. II. Changes of metabolites level and of force during exercise in relation to a fatigability parameter. 408 20