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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

While testing neurotic patients it was noted that almost all of their complaints concerned physical weakness, easy tiredness, chest pain, heart beating and palpitation. In order to evaluate objectively their physical efficiency, the patients were subjected to exercise test on a treadmill, their ECG, HR and blood pressure being monitored. The exercise test was carried out twice, i.e. before and after 3-month psychotherapy. The average physical efficiency coefficient before treatment was significantly lower than after the treatment, but repolarization disorders were significantly higher before the treatment. ECG analysis proved non-specific repolarization changes induced by excitability of sympathetic system. 8 patients showed changes in ST-T before the treatment and 4 persons after it. Another kind of changes (that appeared in 14 cases before the treatment) were extrasystoles mainly supraventricular. After psychotherapy they were noted only in 1 case. The analysis of HR and blood pressure proved a significantly higher HR and lower blood pressure before the treatment. The obtained results may become an argument supporting the functional character of the changes mentioned.
Psychiatr Pol
PMID:[Exercise test in the neurotic patients]. 1021 91

Visual evoked potentials (VEPs) were recorded in a group of 20 operators aged 25-45 years during two sessions, before and after a 5-hour work at computer terminals, in order to assess visual system fatigue. The outcomes were referred to the norms established for the age-matched population of 30 subjects not exposed to professional contact with computers. Most of the examined operators suffered various complaints concerning not only the organ of vision but the central nervous system as well. VEPs were elicited by means of monocular stimulation using the reversal checkerboard pattern and recorded simultaneously from the scalp electrodes placed over the right and the left cerebral hemisphere. Only recording acquired after finishing of a working day demonstrated significant statistically abnormalities of the VEPs waveforms, which suggests their transient character. The changes mentioned above included prolongation of peaks P100 and N2 latency with concomitant attenuation of their amplitudes and a decrease of the correlation coefficient values for the recordings from the hemispheres. The preliminary findings presented in this paper seem to justify a conclusion that the non-invasive VEPs method can be considered as the objective indicator of the central visual fatigue induced by the workload at computer terminals.
Neurol Neurochir Pol
PMID:[The evaluation of central visual fatigue in computer terminal users by visual evoked potentials]. 1035 27

Despite numerous studies the relationship between depression and Alzheimer's disease has not yet been clarified. The high prevalence of depression in Alzheimer's disease has been confirmed but the data on its incidence vary. Generally, depressed mood is the most prevalent symptom in 0-86% of dementia syndrome, minor depression, dysthymia is considered to be present in 20-30% of patients and major depression is least frequent. It seems confirmed that depression may be considered to be a risk factor for dementia, but the coincidence of these two diseases remains still unknown. Since the symptoms of depression and dementia are very similar, the clinical picture brings other controversies. Loss of energy, speech paucity, poor attention and concentration, diminished interest and psychomotor slowness cannot differentiate dementia from depression, the disability level seems to be the only differentiating factor. Depression may be suspected in case of changes in functional level, complaints about pain and diurnal variation of symptoms. From the practical point of view the type of contact and the willingness of perform tests are among the crucial symptoms. Sometimes, it is difficult to separate apathy and pathological crying from depression. The pathomechanism of depression in dementia is not known. The role of serotoninergic and cholinergic transmission changes, alterations of glucocorticoid cascade and presence of apoE are considered but without evident results.
Neurol Neurochir Pol 1999
PMID:[Depression and Alzheimer's disease]. 1040 20

The authors discuss the significance of interbody fusion for early and long term stability of the lumbar spine. They stress that the aim of the modern spinal instrumentation is to promote bone healing and not to replace fusion. Without fusion every stabilization device will fail in fatigue. The biomechanics of different types of spinal fusion and biomechanical conditions at fusion site are discussed. A history of lumbar interbody fusion including threaded implants (cages) is presented. Interbody cages combine positive properties of tricortical bone graft: the strength of cortical to the bone with improved incorporation properties of cancellous bone. In contrast bone graft their biomechanical performance is far better: they increase strength and stability of osteosynthesis, do not go collapse and resorption, prevent from decrease in disc space height and kyphotic angulation of the fused motion segment, require less bone to achieve fusion. They can be used solely without support of any stabilization system. Preliminary experience in fusion with interbody threaded implants suggest significant efficacy of this method.
Neurol Neurochir Pol
PMID:[Lumbar interbody fusion. Biomechanical significance for the spine]. 1046 37

The interrelationship between psychological examination and MRI findings was studied in 70 patients with MS. The cognitive and emotional functions were examined by a battery of tests: Wechsler Adult Intelligence Scale, Visual Retention Test, Hamilton Depression Scale. In MRI examination the localization, area, and the morphology of the plaques were examined. According to plaque's morphology the patients were divided into two groups: with confluent plaques and those with patchy-shaped ones. The signs of dementia were found significantly more frequently in the group with confluent plaques (p. < 0.04). In this group of patients also single-function disorders like disturbances of verbal memory, attention, visual memory, cause- and effect thinking, abstract thinking, and visual-motor coordination were significantly more frequent (p. < 0.01). In the same group the signs of fatigue syndrome were more frequently encountered (p. < 0.02). The authors conclude that the disturbances found in cognitive function may reflect the symptoms of subcortical dementia in MS patients.
Neurol Neurochir Pol
PMID:[Morphology of demyelination plaques vs cognitive and emotional disorders in multiple sclerosis patients]. 1084 2

The analysis of symptom checklists completed by 3196 patients before treatment--1970 females and 1226 males starting the therapy due to neurotic disorders--revealed that 12 symptoms occur im more than 80% of patients; 9 symptoms in 70-80%, 18 dysfunctions in 70-60% and 17 other dysfunctions in 60-50% of examined population. This means that a large number of symptoms including tension, mood depression an anxiety as well as difficulties in concentration, lack of self-confidence, sense of tiredness, loss of energy, persistent thoughts and images, constant fear, absent-mindedness, motor tensions, pessimism, thought flood, the sense of difficulty in thinking and tachycardia occur in almost all patients suffering from neurotic disorders, mo matter what these disorders are. Tle largest group consisted of patients with the diagnosis of anxiety disorders like phobias and the like (ca. 25%). Results of the study suggest the necessity of verification of the present views on the picture of dysfunctions combining into neurotic disorders. A similar occurrence rate of ca. 30% of the 95 analysed dysfunctions in the subgroups of females and males as well as a higher occurrence rate of 10% of the dysfunctions in the male group also make it necessary to verify the prevalent convictions about the sex-dependent differences in the picture and course of neurotic disorders.
Psychiatr Pol
PMID:[Neurotic symptoms frequency]. 1085 53

The authors present a case of fatigue fracture of the proximal tibia with concurrent degenerative changes of the knee in a 53 year old patient with rheumatoid arthritis. The patient was treated surgically with a hinge-rotation prothesis. The procedure yielded pain relief, correction of the axis of the lower limb with progressive bone union.
Chir Narzadow Ruchu Ortop Pol 2000
PMID:[Fatigue tibial fracture coexistent with severe degenerative changes of the knee in a patient with rheumatoid arthritis]. 1096 35

Primary biliary cirrhosis is a chronic, progressive cholestatic liver disease characterised by the destruction of small intrahepatic bile ducts. Although known for many years its etiology and pathogenesis still remains uncertain. Alterations of humoral and cellular immune functions suggests an autoimmune pathogenesis. Primary biliary cirrhosis typically affects middle-aged women who reports fatigue and itching. Diagnosis is usually based on abnormal biochemical tests of liver function, presence of antimitochodrial antibodies (especially anti-M2) and histologic evaluation of liver biopsy specimens. Relatively small number of diagnosed cases in Poland may be due to insufficient knowledge on this disease in our country.
Pol Merkur Lekarski 2000 Jun
PMID:[Primary biliary cirrhosis]. 1096 8

The aim of the study was to assess the effect of 1-year captopril therapy initiated 1-4 days (mean: 21-24 h) after beginning of AMI on exercise performance and myocardial ischemia during cycle ergometer test. 93 pts with first documented Q-wave AMI, aged L 70 years were qualified for the study. 50 of the pts were randomly included to the captopril group, 43 to the control group. In both groups pts with inferior AMI (accordingly 66% and 72%) and normal LV function (EF > or = 40% in ECHO) were prevailed in the study. Captopril therapy was initiated with the dose of 3.125 mg, then every 8 hours the dose of 6.25 mg was administered in Ist and IInd day, 12.5 mg--in III day and 25 mg from IV day on. Exercise cycle ergometer tests (ExT) were performed in every pt at 14 day, and 1, 3, 6 and 12 months after AMI. The ExT began at 25 W of power and was increased at 2-minute intervals by 25 W until fatigue or other typical cause of termination of the test. In the captopril group duration of ExT lengthened significantly in comparison with initial test (on 14 day) after 3 (6.4 +/- 1.47 vs 5.3 +/- 1.54 min; p < 0.01), 6 (6.7 +/- 1.59 vs 5.3 +/- 1.54 min; p < 0.001) and 12 months (7.0 +/- 1.22 vs 5.3 +/- 1.54 min; p < 0.001). In the control group exercise time was longer after 6 and 12 months compared to initial examination (accordingly 6.4 +/- 1.43 and 6.5 +/- 1.26 vs 4.8 +/- 1.47 min; p < 0.001). However, the differences regarding this time between the captopril and control group were not significant on consecutive control stages. The final result of the test (positive, negative, doubtful) did not differ significantly in both groups on consecutive examination stages. Captopril administered during 1-year period after AMI slightly improved physical working capacity (accelerated the improvement) and had no effect on ischemia during estimated cycle ergometer test. These results may depend on inclusion to the study predominantly pts with normal LV function and interior MI.
Pol Merkur Lekarski 2000 Aug
PMID:[The effect of one-year treatment with captopril on exercise tolerance and myocardial ischemia in patients with myocardial infarction ]. 1108 19

In Orthopaedic University Department in Lublin in years 1993-1998 39 patients with thoraco-lumbar spine injuries were treated including 34 fractures and 5 luxations. All of them were treated by surgery. Complete neurological palsy (Frankel A) occurred in 16 patients. Grade E on Frankel scale e.g. no neurological symptoms was in 2 cases. The operations consisted of wide laminectomy with interpedicular joints resection. It gave chance to mobilise the dural sac with its contents. In this situation it was possible to remodel the anterior wall of spinal canal by removal of fractured bony pieces from vertebral body or fibroid remnants of damaged disc. Injured segments of the spine were stabilized by Kluger's fixateur. In 20 cases reduction of vertebral body fracture and filting of bone loss by autogenic spongiosa grafts from iliac crest as proposed by Daniaux was done. In 6 patients posterior interbody spondylodesis was done also with iliac crest grafts. In 9 patients who had only reduction of injured segments, without vertebral body reconstruction and spondylodesis loss of correction occurred after fixateur removal. In 3 patients fatigue break of screws or stabilizing rods developed. It happened 12-16 months after surgical procedure. In patients with primary complete neurological palsy from the level of injury (Frankel A) no symptoms of function improvement appeared higher than one grade in Frankel's scale.
Neurol Neurochir Pol
PMID:[Use of transpedicular fixation in treatment of thoraco-lumbar spinal injuries]. 1131 95


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