Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The author reports changes in vibration and two-point discrimation sensitivity in groups of healthy young males after several days of intense physical effort and after one short-lasting intense exercise. The vibration sensitivity was a steady type of sensory function showing no significant changes after these workloads. The two-point discrimination sensitivity was, not infrequently, better after several days of effort in relation to preliminary state, and it was regarded as an evidence of adaptation to work. On the other hand, one sort-lasting exercise reduced significantly discrimination of two stimuli, especially on the lower extremities. This significant impairment of two-stimuli discrimination on the lower extremities in relation to the upper ones after intensive effort suggests easier exhaustion of pathways conveying sensation in the thoracic segment of the spinal cord. On the basis of these investigations the author thinks that aesthesiometric investigations carried out under strictly observed conditions may be useful for assessment of fatigue.
Neurol Neurochir Pol
PMID:[Effect of various forms of physical exertion on selected types of sensory function]. 48 91

Isolation of a peptide inhibiting glucose absorption by red blood cells from plasma of healthy subjects performing physical exercise. Acta Physiol. Pol. 1977, 28 (2): 117--125. A peptide inhibiting glucose absorption by erythrocytes was isolated from the plasma of healthy males age 23-24 years subjected to physical exercise of increasing intensity from 1 to 3 W/kg of body weight during 18 min. This peptide was not found in the blood plasma obtained from these subjects before exercise as well as in the initial stage of exercise. It appeared in the plasma at the end of the exercise period when symptoms of fatigue were already evident. In view of this it is suggested to call it "fatigue peptide".
Acta Physiol Pol
PMID:Isolation of a peptide inhibiting glucose absorption by red blood cells from plasma of healthy subjects performing physical exercise. 86 30

The aim of the present study was to assess the significance of different types of loads to which working women are subjected in relation to reported chronic fatigue. The investigation involved 255 women workers from two different occupational groups. The first group was employed at knitting and the second at assembly lines. Their level of chronic fatigue was assessed. We also analysed the influence of 30 variables on fatigue level. These variables concerned: a) physical and psychological workload, b) organizational (social) climate of work, and c) demographic and family factors. It was found that the most important factor influencing chronic fatigue was "experiencing emotional tension" resulting from family problems. Other factors, having substantial significance for the development of increased fatigue level were also associated with emotional tension and resulted from the social climate in the workplace.
Pol J Occup Med Environ Health 1992
PMID:The influence of occupational and non-occupational factors on chronic fatigue in women. 129 81

Non-A, non-B hepatitis has been diagnosed in 12 blood donors in a plasmapheresis unit. The course of the disease has been symptomatic, accompanied by jaundice, fatigue, and nausea in 8 cases, and subclinical in the remaining 4 patients. Nine patients were followed-up to 2 years and only 2 patients liver biochemical tests were normalized permanently. The biopsies performed, a year after the acute phase of hepatitis period revealed chronic active disease in patients, chronic persistent hepatitis in 2 patients, acute hepatitis in one, and normal liver in one patient. Repeated liver biopsies, performed one year later, have basically shown similar lesions except one patient in whom chronic active hepatitis progressed to incipient liver cirrhosis. No symptoms of the disease have been usually noted in patients with chronic form of the disease, and liver function tests have occasionally been normal.
Pol Tyg Lek
PMID:[Epidemic focus of non-A, non-B viral hepatitis in a plasmapheresis unit]. 143 24

A case of congenital, isolated tricuspid regurgitation is reported. A 48 year old woman has been admitted because of shortness of breath and progressive fatigue. Although the heart murmur had been heard in her childhood, the first symptoms appeared when she was 25. One year later she underwent a plastic surgery of tricuspid valve. During the following 20 years she remained asymptomatic, until dyspnea and fatigue developed again. On admission she was cyanotic and positive, systolic jugular venous pulse was seen. Atrial flutter was present and no systolic cardiac murmur was heart. The liver was enlarged without peripheral oedema. Echo-Doppler examination and cardiac catheterisation revealed huge right cardiac chambers and significant tricuspid regurgitation. During reoperation a valve consisting of only two cusps was found with extremely dilated valvular anulus. A Bex valvuloplasty was successfully performed. One month later a control echo-Doppler showed the diminution of right ventricle and right atrium with hardly visible regurgitant jet. The pathogenesis and the course of this extremely rare disease have been also discussed in the paper.
Kardiol Pol 1992 Sep
PMID:[Isolated congenital tricuspid valve insufficiency--case report]. 147 73

The activity of alanine and asparagine transaminase and of acid and basic phosphatase was studied in blood serum of 72 porkers of the Polish large-white breed, fed with PT-2 feeds of various protein and energy levels. It was found that the activity of both transaminases in blood serum depended on the protein-energy level of the diet. The activity of transaminases was not found to increase at the protein content compatible with the standard and at increased energy value of the feeds, whereas the same protein level and decreased energy amount caused a decrease in the activity of alanine and asparagine transaminase. At a decreased protein content in the diet the activity of transaminases in plasma was lower than in the porkers on a diet containing protein according to the standard. An increased amount of energy with a decreased protein content in the diet did not affect the activity of asparagine transaminase but slightly stimulated alanine transaminase, whereas a decrease in the amount both of energy and protein in the diet caused an increase in the activity of both transaminases. Acid and basic phosphatase were not adequate indices of changes in the organism of the porkers in relation to the protein-energy level of their diet.
Pol Arch Weter 1987
PMID:[Alanine and aspartate transaminase and acid and alkaline phosphatase activities in the blood serum in relation to the protein and energy levels in the pigs' feeds]. 350 74

The lipolytic response to fatigue-induced stress was studied in fed and fasted rabbits and in fed propranolol-treated rabbits. The initial plasma glycerol level was higher and the increase in glycerol after stress was lower in fasted as compared to fed animals. Propranolol lowered the initial glycerol level and attenuated the fatigue-induced rise in glycerol concentration. The data suggest that in rabbits, as in other species, catecholamines increase lipolysis through stimulation of beta-adrenoceptors. The increment in alpha-adrenergic responsiveness during fasting may contribute to decreased glycerol response to stress observed in fasted rabbits.
Acta Physiol Pol
PMID:Changes in plasma glycerol level in rabbits during fatigue-induced stress. 654 90

Changes in plasma dopamine-beta-hydroxylase (DBH) activity were studied in rabbits subjected to two kinds of acute stress: insulin-induced hypoglycaemia and fatigue. A significant elevation of DBH levels was found both 30 minutes after fatigue-induced stress (p less than 0.001) and 90 minutes after insulin injection (p less than 0.01) when compared with the control values. Responses to these two kinds of stress are reported to be mediated by the sympathetic nervous system, mainly by the adrenal glands. Thus, these results suggest that plasma DBH level is a good index of acute alterations in sympathetic activity in rabbits.
Acta Physiol Pol
PMID:Plasma dopamine-beta-hydroxylase (DBH) activity in two kinds of acute stress in rabbits. 676 83

The purpose of this study was establishing the effect of moderate exercise on EEG tracings in young epileptics. The model of graded exercise was 15-minute work on a cycle ergometer. The effect of the exercise on the pattern of simultaneously recorded EEG was compared with the effect of 3-minute hyperventilation. After testing a control group of 20 young subjects without evidence of organic brain damage or with this damage causing no epilepsy another group of 43 epileptics was studied. In none of these patients the intensity of changes in EEG increased during the exercise but evident EEG differences could be detected during different stages of the exercise in 28 patients with significant generalized discharges. It was found that during the exercise in nearly all patients the number of discharges decreased while during hyperventilation it increased. In 10 patients in this group a repeated rise in the number of discharges was observed immediately after the exercise which was connected usually with greater fatigue after the exercise. In the light of these results the authors conclude that moderate exercise inhibits rather seizure activity in EEG contrary to hyperventilation which increases these changes.
Neurol Neurochir Pol
PMID:[Effect of physical exertion on seizure discharges in the EEG of epilepsy patients]. 680 81

The effect of fatigue-induced stress and of alpha- and beta-adrenoceptor antagonists (phentolamine and propranolol) on plasma free fatty acids (FFA) level was studied in fed and 24 h fasted rabbits. The initial FFA level was significantly higher in the fasted animals than in the fed ones. In the fed control rabbits immediately after stress the FFA level did not change as compared with its initial level. In the fasted control animals directly after stress a marked decrease in the FFA level was observed as compared with its initial value. 15 and 30 min after fatigue-induced stress, both in the fed and fasted control rabbits, a decrease in the FFA level was recorded as compared to that immediately after stress. It was found that propranolol had no significant influence on the FFA level, both in the fed and fasted animals, and phentolamine produced a distinct increase in the FFA level in the fed rabbits only. Immediately after stress the FFA level in the fed propranolol-treated rabbits was unchanged, but in the fed phentolamine-treated animals it was markedly decreased. Directly after stress a decrease of the amount of FFA in the fasted adrenolytic-treated rabbits was recorded, 15 and 30 min after stress the FFA level decreased both in the fed and fasted adrenolytic-treated rabbits. However, this decrease was not as marked as in the fed and fasted control animals. The possible role of lactate and of catecholamines in the changes of plasma FFA concentration was discussed.
Acta Physiol Pol
PMID:Changes in the plasma concentration of free fatty acids in rabbits under fatigue-induced stress. 718 55


1 2 3 4 5 6 7 8 9 10 Next >>