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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors developed a new measure of subjective health status for patients with heart failure. Eighty-eight patients with heart failure were asked about the impact of their condition on 123 items related to physical and emotional function. The most frequently chosen and important items were included in a 16-item Chronic Heart Failure Questionnaire (CHQ) that examines dyspnea during daily activities, fatigue, and emotional function. The CHQ was tested in a controlled trial of digoxin in heart failure patients in sinus rhythm. When administered serially to 25 patients in the run-in phase of the trial, the CHQ proved reproducible. Subsequently, CHQ results distinguished those who reported improvement or deterioration from those who did not. The CHQ showed moderate correlations with patient global ratings, walk test scores, and clinical assessments of heart failure. The authors conclude that the CHQ may be useful for measuring health status in clinical trials in heart failure.
J Gen Intern Med
PMID:Development and testing of a new measure of health status for clinical trials in heart failure. 270 67

The present review considers a series of studies of noise conducted in collaboration with Dr. Michel Loeb. This review attempts to provide a theoretical perspective as well as to summarize the most important findings of those studies. The work reviewed shows that noise effects interact with other variables, such that a noise effect on one sex is reversed for the other, and is also reversed at different times of the day. A second experiment confirmed this finding with a different arithmetic task. Further work indicated parallels between noise and fatigue, with aftereffects depending upon both work and noise. The final experiment repeated some of these findings with a different task battery of information processing tasks while showing that noise effects further depend on the meaningfulness of the noise background.
J Gen Psychol 1987 Oct
PMID:Toward meaningful noise research. 332 19

In a multicenter placebo-controlled study, the safety, side effects, and patient acceptance of alprazolam for the treatment of panic disorder and agoraphobia were examined. A total of 525 patients meeting DSM-III criteria for agoraphobia with panic attacks or panic disorder were randomly assigned to receive alprazolam or placebo, which they took for eight weeks. The mean daily dose at the end of the study was 5.7 mg of alprazolam or 7.5 capsules of placebo daily. Potentially serious reactions to alprazolam occurred in ten of 263 subjects who received the drug. These included acute intoxication (three), hepatitis (two), mania (two), amnesia (one), aggressive behavior (one), and depression (one). Treatment-related side effects that were worse in patients taking alprazolam than in those taking placebo included sedation, fatigue, ataxia, slurred speech, and amnesia. Sedation was the most frequent but tended to subside with dose reduction or continued administration of the drug. Patient acceptance of alprazolam, as measured by the rate of completion for study participants, was high. Eighty-four percent of patients receiving active drug completed the study compared with 50% receiving placebo.
Arch Gen Psychiatry 1988 May
PMID:Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. II. Patient acceptance, side effects, and safety. 335 44

The goals of this study were to examine, in greater detail, the experience of depression in the medically ill, and to compare their experience with that of depressed psychiatric patients. Medical and psychiatric inpatients were matched in terms of total scores on the Beck Depression Inventory (BDI). In addition to the BDI, all patients completed a self-report symptom battery. No difference was found between the two groups in terms of total BDI scores, but psychiatric patients scored significantly higher on the affective BDI items, and medical patients scored significantly higher on the somatic BDI items. Discriminant analysis was used to compare their responses to the symptom battery. Depression in the psychiatric patients was characterized primarily by suicidal ideation and loss of interest, whereas in medical patients a lack of energy and worry were the predominant symptoms. The implications of these findings for assessing depression in the medically ill are discussed.
Gen Hosp Psychiatry 1987 Nov
PMID:A comparison of the symptoms of medical and psychiatric patients matched on the Beck Depression Inventory. 369 46

Mood changes of interns during the internship year were studied using the Profile of Mood States (POMS), a standardized adjective checklist. All 35 interns in the University of California, Irvine-Long Beach Medical Program completed the POMS at internship orientation and at five other times during the year. Of the six mood factors measured by the POMS, four changed significantly during the testing period. Anger-hostility scores were higher (p less than 0.01) in December than at orientation and remained so throughout the year. Tension-anxiety scores were higher (p less than 0.01) and fatigue-inertia scores were lower (p less than 0.01) at orientation than at any other time during the year. Vigor-activity scores were higher (p less than 0.01) at orientation than at the end of the year. Depression-dejection and confusion-bewilderment scores did not change significantly during the study period. Recognition of these mood changes is helpful for drawing the attention of house staff and faculty members to emotional stresses of training, and for identifying issues for discussion in intern support groups.
J Gen Intern Med
PMID:Stress during internship: a prospective study of mood states. 377 96

The dynamic characteristics of the rat gracilis anticus muscle at 17.5 degrees C have been determined by isotonic and isometric loading. For a fixed initial length these characteristics were represented either as a family of length-velocity phase trajectories at various isotonic afterloads or as a series of force-velocity curves at different lengths. An alternate method of viewing these data, the length-external load-velocity phase space, was also generated. When the muscle was allowed to shorten from different initial lengths, the velocity of shortening achieved at a given length was lower for longer initial lengths. The amount of departure was also dependent upon the isotonic load, the greater the load the greater the departure. The departures were not caused by changes in the elastic elements of the muscle or fatigue in the ordinary sense. When the behavior of the muscle was investigated at different frequencies of stimulation, the shortening velocity was a function of the number of stimulating pulses received by the muscle at a given frequency. The shortening velocity of the rat gracilis anticus muscle is, therefore, not only a function of load and length, but also of an additional variable related to the time elapsed from onset of stimulation.
J Gen Physiol 1968 Mar
PMID:The dynamic properties of mammalian skeletal muscle. 564 33

Oxazepam and diazepam were compared in healthy elderly volunteers. Absorption of diazepam was faster than oxazepam and onset of clinical effects were more profound. Diazepam accumulation was extensive, washout was slow and active compounds were present two weeks after the last dose. Oxazepam accumulation was significantly less and elimination significantly faster than diazepam. There was no difference between oxazepam and diazepam in sedation or fatigue during the drug treatment, but sedative effects persisted for two weeks after diazepam therapy was discontinued. Sedation rapidly returned to baseline in the oxazepam group. Thus, the differing pharmacokinetic profiles of diazepam and oxazepam have clinical consequences during multiple dosage in the elderly.
Arch Gen Psychiatry 1983 Mar
PMID:Long v short half-life benzodiazepines in the elderly. Kinetics and clinical effects of diazepam and oxazepam. 683 Apr 8

The present study investigated the extent to which fatigue influenced the usage of feedback by Ss to make corrections during coincident timing responses. Sixteen college males watched a .01-sec timer and attempted to knock over a barrier at the moment that the sweep hand reached 500 msec. All Ss were given 50 trials of practice on each of four consecutive days. The fatigue group's performance was immediately preceded by a response-specific local fatigue (dynamic exercise). To insure the maintenance of a high level of fatigue throughout practice, the fatiguing exercise was interspersed with the coincident timing task. The control group performed the same exercise as the fatigue group but without any resistance. Schmidt's (1972) index of preprogramming (IP) was calculated for each day in order to determine the level of feedback involvement in controlling the movement. Fatigue did not influence the accuracy with which Ss responded or the rate that they learned. However, the results indicated a relatively high and stable IP throughout all trials with the IP for the fatigue group higher than that of the control, suggesting a preference by these Ss for a programming mode of control.
J Gen Psychol 1982 Apr
PMID:The effects of fatigue on the control of a coincident timing response. 709 59

In a double-blind crossover study the beta-adrenergic blocking drug propranolol hydrochloride reduced symptoms in 17 of 26 patients with chronic anxiety disorders. Both somatic and psychic symptoms improved as judged by patient and observer ratings. The most frequent side effects (dizziness, fatigue, and insomnia) were difficult to distinguish from anxiety symptoms and were, for the most part, mild. The therapeutic and side effects observed suggested CNS activity of the drug. Although propranolol is of benefit to patients with anxiety, its efficacy, compared with that of other antianxiety drugs, has not been established.
Arch Gen Psychiatry 1980 Dec
PMID:Propranolol in chronic anxiety disorders. A controlled study. 744 18

Limitation of resident working hours has been a critical issue for training programs in recent years. At Providence Medical Center, residents and faculty collaborated in developing goals, implementation strategies, and an evaluation process for a new ward float system. The goals of the float system were to reduce fatigue, facilitate education, maintain continuity of care, and minimize the negative impact of training on residents' personal lives. Evaluation revealed: 1) 74% of the residents preferred Providence Medical Center float system (PMCF) to either night float (NF) (13%) or standard every-fourth-night call (EFNC) (13%); and 2) PMCF was perceived to ensure quality patient care to a greater degree than was NF, to better facilitate resident education than was NF, and to have a less negative impact on personal lives than was EFNC.
J Gen Intern Med 1995 Feb
PMID:Beyond night float? The impact of call structure on internal medicine residents. 773 Sep 47


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