Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sequential fatigue fractures of the fourth, second, and third metatarsals in the same foot are reported for a military aviator in the absence of abnormal stresses or underlying bone disease. The likely etiological factor is altered foot biomechanics, as identified in pedobarographic assessment. We have reviewed the literature regarding multiple metatarsal stress fractures.
Mil Med 2006 Apr
PMID:Sequential metatarsal fatigue fractures secondary to abnormal foot biomechanics. 1667 41

This study surveyed health care providers about their evaluation and treatment of mild traumatic brain injury (TBI) in adults. We presented two vignettes describing mild TBI cases to staff in the emergency department (N = 22) and primary care clinics (N = 16) at Wilford Hall Air Force Medical Center and asked how they would evaluate and treat these patients. Most providers said they would assess visual changes, nausea/vomiting, headache, and neck pain. More emergency department personnel than primary care clinic providers would make referrals to different specialties, whereas more primary care clinic providers would schedule a follow-up appointment. Neither group of providers mentioned assessing common postconcussive symptoms of fatigue, emotional changes, and problems sleeping. Comparing findings to current literature suggest that added focus on emotional, cognitive and psychosocial factors, and education of the patient and family could improve early identification of mild TBI patients at risk for poor recovery.
Mil Med 2006 Jun
PMID:A survey of mild traumatic brain injury treatment in the emergency room and primary care medical clinics. 1680 33

Although the health benefits of exercise for individuals with Persian Gulf War veterans illnesses (GWVI) are documented, many of these individuals do not exercise regularly enough to obtain benefits. The purpose of this study was to investigate factors predicting exercise compliance among individuals with GWVI in a multicenter, randomized, clinical trial. Participants were 1,092 veterans who reported at least two of the following cardinal symptoms of GWVI: (1) fatigue, (2) musculoskeletal pain, and (3) cognitive problems. Participants received exercise alone or exercise and cognitive-behavioral therapy. The overall level of compliance was relatively low during the exercise treatment phase (46.2%) and decreased by one-half during the follow-up period (23.0%). Predictors of compliance during treatment included less pain and greater age, motivation, and body mass index. Predictors of compliance during the follow-up period included less pain and greater age. The results highlight factors that affect adoption and maintenance of physical activity in a population with GWVI.
Mil Med 2006 Sep
PMID:Predictors of exercise compliance in individuals with Gulf War veterans illnesses: Department of Veterans Affairs Cooperative Study 470. 1703 19

The proposition that the demands of recruit training, including physical and psychological stresses, result in symptoms of overtraining was investigated during the 45-day Army Common Recruit Training course. Body mass, physical fitness, fasting blood measures of immune status, hormones (serum free testosterone/cortisol ratio), inflammation, and iron status were measured at baseline and after weeks 5 and 6. Psychological measures of mood and fatigue and general health were measured at the end of each week. Sleep diaries were completed each evening and morning. Evidence for overtraining symptoms of fatigue, sleep disturbance, immune suppression, reduced iron status, high rates of minor injuries, and hormonal changes was found. However, recruits were not pushed so hard that physical performance deteriorated greatly. Accumulated sleep deprivation might be a major contributor to the adverse hormonal changes. We conclude that there was some evidence of recruits being overtrained.
Mil Med 2006 Nov
PMID:Australian army recruits in training display symptoms of overtraining. 1715 42

In response to questions about the safety of ephedra-based dietary products, ephedra-free products are now available. Many contain synephrine, a sympathomimetic amine with structural similarities to ephedra. We present a 22-year-old, previously healthy, African American male with sickle cell trait who developed rhabdomyolysis after ingestion of a synephrine-containing dietary supplement. The patient developed fatigue, dehydration, and myalgias while exercising. He developed severe rhabdomyolysis, with a peak creatine phosphokinase level of 2.8 million U/L, complicated by pulmonary edema, acute renal failure, disseminated intravascular coagulation, and bilateral compartment syndromes in his lower extremities. He required prolonged hospitalization for hemodialysis, multiple wound debridements, hyperbaric oxygen therapy, and physical therapy. He has permanent sensory and motor neurological deficits in his distal lower extremities. Military physicians should routinely inquire about the use of dietary supplements, educate patients about the potential adverse reactions associated with these agents, and encourage healthy diets and exercise for weight loss.
Mil Med 2007 Jun
PMID:A case of severe exercise-induced rhabdomyolysis associated with a weight-loss dietary supplement. 1761 52

The purpose of this study was to identify the effects of gender and body adiposity on physiological responses to the stress of wearing body armor. Using a within-subject, repeated-measures design, 37 military personnel volunteered to undergo two experimental conditions, with body armor and without body armor. Female and male subjects with body armor, compared to those without body armor, had no significant differences in percentage increases in aerobic capacity, heart rate, or respiratory rate while walking at slow or moderate pace. However, women, as compared to men, had a significantly increased difference in the rating of perceived physical exertion between wearing and not wearing body armor at a slow pace. Fourteen subjects were not able to complete treadmill testing while wearing body armor because of volitional fatigue and/or limiting dyspnea. Body fat was the best single predictor of treadmill test completion.
Mil Med 2007 Jul
PMID:Effects of gender and body adiposity on physiological responses to physical work while wearing body armor. 1769 88

One of the hallmarks of obstructive sleep apnea (OSA) is loud snoring. Army conscripts sleep in barracks, and loud snorers are easily detected. We made polygraphic recordings from these snorers during one night spent in the hospital, to find the ones suffering from OSA. Forty-nine conscripts (all male; mean age, 21 +/- 2 years; body mass index, 25 +/- 3 kg/m2) were studied; 32 (65%) complained about daytime sleepiness, and one had caused a shipwreck during an episode of fatigue. Oxygen levels decreased 4 to 9% >20 times per hour (4-9% oxygen desaturation index [ODI4] of >20 hours) for three subjects (6%). Eleven additional subjects (22%) had ODI4 values of >10 hours. Four (8%) of them did not complain about daytime sleepiness. The mean apnea index (AI) was 11 +/- 13 hours; 20 patients (41%) had AI values exceeding 10 hours. ODI4 and AI were significantly correlated (r = 0.67; p < 0.001). Body mass index did not correlate significantly with ODI4 or apnea index. Approximately one-fifth of loudly snoring conscripts suffer from OSA. Loud snorers should be examined before being selected for duties requiring maintenance of high alertness.
Mil Med 2007 Aug
PMID:Obstructive sleep apnea in loudly snoring army conscripts. 1780 83

Caffeine has been suggested to act as a countermeasure against fatigue in military operations. In this randomized, double-blind, placebo-controlled study, the effect of caffeine on simulator flight performance was examined in 13 military pilots during 37 hours of sleep deprivation. Each subject performed a flight mission in simulator four times. The subjects received either a placebo (six subjects) or 200 mg of caffeine (seven subjects) 1 hour before the simulated flights. A moderate 200 mg intake of caffeine was associated with higher axillary temperatures, but it did not affect subjectively assessed sleepiness. Flight performance was similar in both groups during the four rounds flown under sleep deprivation. However, subjective evaluation of overall flight performance in the caffeine group tended to be too optimistic, indicating a potential flight safety problem. Based on our results, we do not recommend using caffeine pills in military flight operations.
Mil Med 2007 Sep
PMID:Effect of caffeine on simulator flight performance in sleep-deprived military pilot students. 1793 64

The purpose of this study was to examine physical work performance, energy cost, and physiological fatigue in military personnel during simulated operational conditions. Using a within-subject, repeated-measures design, 34 military personnel volunteered to undergo two experimental conditions: with body armor (BA+) and without BA (BA-). Subjects walked on a treadmill for 30 minutes and completed a physical performance battery during each of two sessions, which were separated by > or = 5 days. Subjects with BA+ as compared with BA- had significantly greater increases in: oxygen uptake (VO2) at slow (16.8 +/- 1.5 vs. 18.8 +/- 1.7 mL x kg(-1) x min(-1)) and moderate paces (34.8 +/- 3.9 vs. 40.8 +/- 5.0 mL x kg(-1) x min(-1)); blood lactate at a moderate pace (4.0 +/- 2.4 vs. 6.7 +/- 2.6 mmol/L); heart rate at slow (107 +/- 14 vs. 118 +/- 16 beats per minute) and moderate paces (164 +/- 16 vs. 180 +/- 13 beats per minute); and ratings of perceived physical exertion at slow (8.4 +/- 1.5 vs. 10.4 +/- 1.8) and moderate paces (14.3 +/- 2.3 vs. 16.7 +/- 2.1). Physical tasks were significantly affected by BA: under BA+, men performed 61% fewer pull-ups and women's hang time was reduced by 63%; stair stepping was reduced by 16% for both men and women. BA significantly impacted the physical work capacity of militarily relevant tasks. Specifically, wearing BA significantly increased VO2 when walking at both slow and moderate paces. The potential for physical exhaustion is high and performance of physical tasks is markedly impaired when wearing BA.
Mil Med 2008 Sep
PMID:Metabolic demands of body armor on physical performance in simulated conditions. 1881 20

The current military battlefield requires aviators to make split-second decisions that often have life-and-death consequences, making identifying predictors of diminished cognitive performance a vital aeromedical and safety concern. The current study explored the relationship between aviator effectiveness, as determined by sleep-wake patterns, and neurocognitive functioning in a brigade-size rotary wing aviation element deployed in Iraq. Actigraphy and the Fatigue Avoidance Scheduling Tool (FAST) were used to assess the ratio of sleep-wake patterns over a 24-hour time period, and a computerized multitasking measure, which mimics the task demands of flying, was utilized to evaluate neurocognitive functioning during preflight operations. Results showed a significant positive association between level of effectiveness and neurocognitive functioning before flight operations. The reported sleep habits and trends in types of sleep difficulties are noted. The results speak to the potential efficacy of using actigraphy and software to evaluate a pilot's effectiveness before flight operations, and suggest that flight surgeons and psychologists may be able to play a vital role in improving overall sleep patterns and enhancing the warfighting efforts of aviators in combat. They also suggest that mandated crew rest and evaluation of total reported sleep time may not be sufficient to ensure optimum performance levels.
Mil Med 2009 Apr
PMID:Managing aviator fatigue in a deployed environment: the relationship between fatigue and neurocognitive functioning. 1948 4


<< Previous 1 2 3 4 5 6 7 Next >>