Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Several hypotheses suggest that alcohol is often used to "escape"--to forget unpleasant feelings resulting from personal problems or social stresses. To test alcohol's effects on memory for feelings, 1.1 ml/kg of alcohol (A) or placebo (P) was given in two sessions, 48 hours apart, to 32 subjects divided into four equal drug groups (P-P, P-A, A-P, A-A). The subjects filled out the Profile on Mood States (POMS) after drug ingestion in session 1 while experiencing and learning these emotions. Their memories were tested when they tried to replicate these POMS ratings after drug ingestion in session 2. Alcohol given before memory testing decreased accuracy on each of the six POMS scales, especially Fatigue. However, alcohol did not impair memory for previously learned verbal and pictorial stimuli, and it produced no measurable changes in current feelings. These findings indicate that the impairment of memory for feelings may be a newly discovered specific pharmacological effect of alcohol.
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PMID:Testing the escape hypotheses. Alcohol helps users to forget their feelings. 684 48

Acute and chronic alcohol intoxication causes a considerable deamidation of central nervous system proteins which is most pronounced in the spinal cord. There occurs rearrangement in the amide bonds lability and in the ratio of easy-hydrolyzable and strongly bound amide groups. The metabolic response to the single administration of ethanol is disturbed. Alcohol intoxication causes changes in the amount of amide groups in the central nervous system proteins under conditions of physical exercises and fatigue development.
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PMID:[Amide groups of brain and spinal proteins in acute and chronic alcohol intoxication]. 719 2

The Eysenck Personality Inventory and Profile of Mood States were administered to 107 men and 43 women before starting methadone maintenance and again after four months of treatment. Both men and women reported decreases in levels of neuroticism, anxiety, and fatigue after four months of treatment. The women described themselves as less depressed, whereas the men indicated that they felt more vigorous. However, the post-test levels of affect for both sexes were still comparable to those reported for outpatient psychoneurotics. The relationships of certain background characteristics and treatment experiences associated with both sexes' changes in affect were also described.
Drug Alcohol Depend 1980 Feb
PMID:Affective changes in male and female methadone patients. 735 69

This study was implemented to evaluate whether perivenous cells experience functional alterations due to a deficit in oxygen tension resulting from ethanol oxidation in the periportal regions of the lobule. Periportal and perivenous hepatocytes were prepared from ethanol-fed and control animals (Lieber-DeCarli diet, 31 days). These cells were either incubated at various oxygen tensions by varying the composition of the gases utilized to equilibrate the incubation buffers (0, 5, 25, and 95% oxygen) or they were unincubated. They were analyzed for adenine nucleotide and inorganic phosphate concentrations and from these data phosphorylation potentials and energy charge values were determined. Under highly aerobic conditions no differences were observed in the energy states of the cells irrespective of their source (control vs ethanol-fed; periportal vs perivenous). The ATP concentrations, phosphorylation potentials, and energy charge values indicated that the energy states of cells from both ethanol-fed and control rats were maintained at relatively high levels in incubations with 5 and 25% oxygen. However, unincubated cells and those incubated at 0% oxygen demonstrated lowered energy states and the decreases were most striking in hepatocytes from ethanol-fed animals. Measurements of LDH loss and trypan blue exclusion indicate that cell leakage and viability loss occur when cells are incubated under anoxic and hypoxic conditions. At low oxygen tensions perivenous cells from ethanol-fed rats demonstrated much greater loss of structural stability than did the other cell preparations. These observations indicate that decreased energy state is one factor which contributes to cell damage in hepatocytes from ethanol-fed animals. Moreover, perivenous cells from ethanol-fed animals seem to be particularly vulnerable to damage under hypoxic conditions.
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PMID:Effect of chronic ethanol consumption on the energy state and structural stability of periportal and perivenous hepatocytes. 757 68

The use of herbal and other "natural" health products by healthy and ill people is more common than is appreciated by many health care providers. Since most of these substances are not categorized as medicines, they are exempt from U.S. Government approval processes, and are essentially uncontrolled. In this article we describe a patient who developed painless jaundice, fatigue, and pruritus after taking chaparral tablets, 160 mg/day, for approximately 2 months. Serial liver biopsies and serum chemistries documented severe cholestasis and hepatocellular injury, i.e., a severe cholangiolitic hepatitis. Serum enzyme levels were markedly elevated: alk. phos. to four-fold, alanine aminotransferase and aspartate aminotransferase to 25-fold, total bilirubin to 30-fold, and gamma-glutamyl transpeptidase to 35-fold. Endoscopic retrograde cholangiopancreatography showed smooth, but severely narrowed biliary ducts without sclerosing cholangitis, distal obstruction, tumor, or stenosis. The diagnosis remained in doubt until the publication of two cases of chaparral hepatotoxicity. Because of the similarity of our patient's illness to those cases we concluded that chaparral was almost certainly the cause. Chaparral, also known as creosote or greasewood, is used by some practitioners to treat a diverse group of ailments including ethanol withdrawal. This report should heighten the awareness by primary care physicians and gastroenterologists that any chaparral herbal preparation is a potential hepatotoxin that can lead to serious illness.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Cholestatic hepatitis after ingestion of chaparral leaf: confirmation by endoscopic retrograde cholangiopancreatography and liver biopsy. 780 38

Factors affecting alcohol behavior were studied using, as a conceptual framework, a Health Behavior Model on Alcohol (Alcohol Behavior Model), adapted from Munakata's Health Behavior Model. Under this model alcohol behavior is restricted or promoted by the levels of self-initiative ability, which influences both health promotion factors and health hindrance factors. How these factors influence alcoholic behavior in company employees was studied. Employees were asked to complete questionnaires when they came to health centers for their regular health examination between August to September 1990. Two hundred and ninety-two of the three hundred subjects answered the questionnaire. Results indicate that the major factor for restricting alcoholic behavior was self-efficacy regarding drinking alcohol. The self-efficacy level was increased by the persons' perceived vulnerability to alcohol and was decreased when alcohol functioned as an aid to recover from fatigue or to lower stress. As a conclusion, empowering clients to enhance self-efficacy appears to be effective as a health objective for coping with alcoholic behavior.
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PMID:[Health behavior model based analysis of factors affecting alcohol behavior of company employees]. 791 68

Healthy sleeping habits is a complex balance between behaviour, environment and circadian rhythm. The quality of sleep can be improved by behaviour, e.g. eating tryptophan and carbohydrate rich foods, physical exercise in the afternoon or a cold shower just before going to bed. Total sleep time is maximal in thermoneutrality and decreases above and below the thermoneutrality zone. Thermoneutrality is reached for an environmental temperature of 30-32 degrees C without night clothing or of 16-19 degrees with a pyjama and at least one sheet. Noise also modifies sleep structure and above 50dB shortens total sleeping time. Although subjects do become subjectively accustomed to noise, vegetative cardiovascular reactivity to environmental noise remains unchanged. The spontaneous circadian awake/sleep cycle is 25 hours, slightly longer than the body temperature cycle, but when subjects are exposed to environmental synchronization, the two cycles coincide. In individuals undergoing temporal isolation, the two rhythms become independent often leading to subjective discomfort and fatigue. Certain factors including age can favour internal desynchronization. Other factors may include social contact, stress due to mental work load, and constant lighting which could lengthen the awake/sleep cycle. Caffeine blocks the receptors of adenosine, and thus its effects of inhibiting neurotransmission. Intake 30 to 60 minutes before sleeping shortens total sleep time and increases the duration of stage 2 and shortens stage 3 and 4. Alcohol may act as a relaxing, sedative agent when consumed just before sleeping but can also lead to night-time awakening due to sympathetic activation which does not return to baseline levels until the blood alcohol levels have returned to 0. Nicotine has a biphasic effect on sleep: at low concentrations, it leads to relaxation and sedation and at high concentrations inhibits sleep. A careful study of sleeping habits is the first step in evaluating complains of insomnia or hypersomnia. Before relying on drugs, treatment should start with attention to the sleep environment and personal habits.
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PMID:[Prevention and treatment of sleep disorders through regulation] of sleeping habits]. 802 26

The relationship between subjective effects and drug preferences in normal volunteers was explored in a meta-analysis of several previously published studies. Subjective effects of, and preference for, ethanol and diazepam vs. placebo were measured using a choice procedure. Subjects were grouped according to their drug choices: 'non-choosers' never chose drug, whereas 'choosers' always chose drug. The two groups were compared on their subjective responses to drug and on demographic variables. Ethanol decreased Arousal, Elation, Positive Mood and Vigor, and increased Anxiety, Depression and Fatigue in the non-choosers, whereas it increased Arousal and Vigor in the choosers. Ethanol choosers were also more likely to be males and/or full-time students than non-choosers. Diazepam produced sedative-like effects in both choosers and non-choosers, but markedly decreased Anxiety and increased Friendliness in choosers only. Diazepam choice was also associated with more frequent recreational use of marijuana and stimulants. Thus, both demographic variables and subjective drug effects were related to drug preference.
Drug Alcohol Depend 1994 Feb
PMID:Relationship between subjective effects and drug preferences: ethanol and diazepam. 803 63

Composite restorative materials wear by a fatigue mechanism in the occlusal contact area. Here, tooth cusps and food debris cyclically indent the restoration. Modeling this phenomenon requires an understanding of material response to indentation. The question in this study was whether material response depends on indenter size and geometry, and also, whether polymers used in restorative materials should be considered elastic and brittle, or plastic and ductile for modeling purposes. Three resins used as matrices in proprietary restorative composites were the experimental materials. To ascertain the influence of glass transition temperature, liquid sorption, and small amounts of filler on indentation response, we prepared materials with various degrees of cure; some samples were soaked in a 50/50 water/ethanol solution, and 3 vol% silica was added in some cases. Indentation experiments revealed that no cracking occurred in any material after indentation by Vickers pyramid or spherical indenters with diameters equal to or smaller than 0.254 mm. Larger spherical indenters induced subsurface median and surface radial and/or ring cracks. Critical loads causing subsurface cracks were measured. Indentation with suitably large spherical indenters provoked an elastoplastic response in polymers, and degree of cure and Tg had less influence on critical load than soaking in solution. Crack morphology was correlated with yield strain. Commonly held assumptions regarding the brittle elastic behavior of composite matrix materials may be incorrect.
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PMID:Indentation cracking of composite matrix materials. 808 42

In order to study the role of drugs in driving, a responsibility analysis was developed to allow an assessment to be made of the driver's culpability or responsibility in an accident. Factors possibly mitigating drivers' responsibility in each accident were identified and scored. Factors considered were: condition of road, condition of vehicle, driving conditions, accident type, witness observations, road law obedience, difficulty of task, and level of fatigue. If a sufficient number of mitigating factors were identified a driver would be found to be either partly or totally exonerated from blameworthiness and scored either as a contributory or nonculpable driver. If drugs present in a driver contributed to accident causation, it would be expected that they would be overrepresented in culpable drivers, i.e. those drivers not exonerated from blame. A total of 341 driver fatalities occurring in Victoria were analysed for blood alcohol content (BAC). Twenty-nine percent had a BAC over .05% (the legal limit in Victoria). Alcohol-positive drivers were statistically overrepresented in the culpable group (p < .001), in single-vehicle accidents (p < .05) and those accidents in which vehicles left the road for no apparent reason (p < .001). Odds-ratio estimation of relative risk of culpable and nonculpable drivers showed that the relative risk rose disproportionately to BAC.
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PMID:Responsibility analysis: a methodology to study the effects of drugs in driving. 819 93


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