Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ten patients aged 5-14 years and 1 adolescent were treated by CAPD during 12 patient years. Overall survival and rehabilitation were good despite relatively high serum concentrations of urea (19 mmol/l) and creatinine (735 mumol/l). Dietary restrictions were only occasionally necessary, 6 patients required phosphate binders. No radiological bone changes developed in 4 patients with initially normal x-rays, but lesions progressed in 3 with pre-existing osteodystrophy despite administration of 1.25 (OH) 2D3 and Al-hydroxide. Statural growth was unsatisfactory: Height decreased in the 7 patients observed over 1 year from -2.4 to -2.7 SDS. Peritoneal diffusion curves varied considerably between patients, yet remained unchanged at repeat examination. Parents fatigue developed in 6 families and was partly responsible for peritonitis. The incidence of peritonitis fell from 1 episode in 3.3 months to 1 in 8 months. Intensive family support by regular telephone contact and home visits appeared as the most important measure in prevention of parents fatigue and hence of peritonitis. We consider CAPD as a valuable alternative method to haemodialysis.
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PMID:[5 years of continuous ambulatory peritoneal dialysis in the child]. 395 93

The effect of the converting enzyme inhibitor captopril as long term treatment was investigated in 14 patients with severe congestive heart failure in a double blind trial. Captopril reduced plasma concentrations of angiotensin II and noradrenaline, with a converse increase in active renin concentration. Effective renal plasma flow increased and renal vascular resistance fell; glomerular filtration rate did not change. Serum urea and creatinine concentrations rose. Both serum and total body potassium contents increased; there were no long term changes in serum concentration or total body content of sodium. Exercise tolerance was appreciably improved, and dyspnoea and fatigue lessened. Left ventricular end systolic and end diastolic dimensions were reduced. There was an appreciable reduction in complex ventricular ectopic rhythms. Adverse effects were few: weight gain and fluid retention were evident in five patients when captopril was introduced and two patients initially experienced mild postural dizziness; rashes in two patients did not recur when the drug was reintroduced at a lower dose; there was a significant reduction in white cell count overall, but the lowest individual white cell count was 4000 X 10(6)/l. Captopril thus seemed to be of considerable value in the long term treatment of severe cardiac failure.
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PMID:Captopril in heart failure. A double blind controlled trial. 638 12

12 Brazilian men were treated with gossypol for 1 year. The treatment schedule consisted of oral administration of 20 mg gossypol daily for 4 months, followed by a maintenance dose of 20 mg on alternate days (o days/week), totaling 60 mg weekly for 8 months. 10 men became azoospermic at the end of the 4th month of treatment, and the other 2 developed marked oligospermia with necrospermia. Except for 1 man who complained of transient listlessness and fatigue, the subjects reported no side effects during treatment. No changes in libido or potency were reported, and plasma testosterone remained unchanged. Blood chemistry values, which included complete blood cell count, cholesterol, glucose, triglycerides, acid phosphatase, urea, transaminases, sodium, and potassium, were not changed significantly during treatment. The response of the pituitary to gonadotropin-releasing hormone stimulation and the response of the testis to gonadotropin stimulation appeared normal in men treated with gossypol. After treatment, sperm counts reverted to essentially normal levels in 8 of 12 men. In 4 men, azoospermia continued 1 year after gossypol treatment discontinuation. Retrograde phlebography carried out in 3 of 4 men who remained azoospermic after therapy discontinuation revealed subclinical varicocele.
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PMID:Antispermatogenic action of gossypol in men. 646 76

To evaluate the degree of physical activity in hemodialysis patients, working capacity was assessed by bicycle ergometry in 16 hemodialysis patients (mean age 47 +/- 12 [SD] years). The mean length of dialysis treatment was 21 +/- 17 months. The laboratory and clinical findings were as follows (mean values +/- SD): urea 34 +/- 6 mmol/l; creatinine 1127 +/- 169 mumol/l; potassium 5.7 +/- 0.63 mmol/l; calcium 2.25 +/- 0.22 mmol/l; phosphate 1.76 +/- 0.54 mmol/l; hemoglobin 8.54 +/- 1.02 g/dl; hematocrit 26.1 +/- 2.9%; blood pressure 140 +/- 18/86 +/- 9 mm Hg; nerve conduction velocity 39.5 +/- 6.5 m/sec. Mean working capacity was 58 +/- 31 W (41 +/- 24% of normal values) and the specific working capacity (watts/kg body weight) was 0.79 +/- 0.54. The duration of exercise testing was 4.9 +/- 2 min. The ergometry had to be discontinued because of the following reasons: leg fatigue (10 patients); general fatigue (3); dyspnea (1); attainment of maximal heart rate (2). The maximal blood pressure during exercise testing was 149 +/- 21/86 +/- 14 mm Hg and the maximal increase in heart rate 117 +/- 34 beats/min. In patients treated with a beta-blocker agent for hypertension, maximal increase in blood pressure was comparable to normotensive patients. There was a negative correlation between working capacity and the age of the patients (r = 0.77; p less than 0.01). A positive correlation was found between working capacity and the serum creatinine level (r = 0.52; p less than 0.05).
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PMID:[Ergometrically determined work capacity in chronic hemodialysis treatment]. 649 68

A randomized double-blind cross-over study into the effect of northisterone on climacteric symptoms was performed on 23 postmenopausal women. Active therapy resulted in a significant reduction in the number and severity of hot flushes and night sweats. There was also a slight improvement in memory, insomnia and lack of energy but the other climacteric symptoms were not consistently altered. Side effects were minimal. There was a significant reduction in serum calcium, alkaline phosphatase, cholesterol, triglycerides, follicle-stimulating hormone and luteinizing hormone levels. There was a variable effect on serum creatinine and urea but there was no significant alteration in the other biochemical profiles, liver-function tests, weight or blood pressure.
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PMID:A randomized double-blind cross-over trial into the effect of norethisterone on climacteric symptoms and biochemical profiles. 680 99

The urinary excretion of 3-methylhistidine has been determined in rats fed an energy-depleted diet. Young male rats were fed over a 21-day period on either an adequate control diet (18% lactalbumin), or an energy-depleted diet (containing half of the amount of carbohydrates of the control diet). Urinary urea-N, creatinine, creatine and 3-methylhistidine, as well as body weight changes were monitored throughout the experiment. At the end of the experiment, the levels of insulin and corticosterone, and the weights of livers and gastrocnemius, soleus, tibialis anterior and extensor digitorum longus muscles were determined. A significant (p less than 0.05) reduction in body and liver weight was found in the energy-depleted rats, but no weight differences were found in the four excised muscles. Urinary outputs of urea-N, creatine and creatinine were significantly (p less than 0.05) increased in this latter group. Output of 3-methylhistidine showed an initial rise followed by a significant (p less than 0.05) and progressive decline throughout the experiment in the rats fed the energy deficient diet. Insulin concentration was significantly (p less than 0.01) reduced in those animals, but no differences were found in the serum levels of corticosterone. It is assumed that lack of energy in the diet decreases the rate of myofibrillar protein breakdown in growing rats.
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PMID:Muscle protein breakdown in young rats fed on a energy-depleted diet. 701 47

A questionnaire study among 70 employees at seven mobile day care centers where urea formaldehyde glued particle board has been used for indoor paneling and among 34 employees at three control institutions selected at random where no particle board has been used as building materials, showed a significantly higher frequency of the following symptoms among the staff at the mobile institutions: mucous membrane irritation, headache, abnormal tiredness, menstrual irregularities and use of analgetics (p less than 0.01). As there was no difference in the age distribution or smoking habits of the two groups working in day care institutions from the same geographical locations, we are, therefore, of the opinion that the differences in the frequency of symptoms discovered must be attributed to the differences in the indoor climate conditions prevalent in the institutions. The median concentration of formaldehyde in the mobile institutions was 0.43 mg/m3 in contrast to a concentration in the control institutions of about 0.08 mg/m3. We assume, therefore, that the higher concentration of formaldehyde in the mobile institutions was a cause of the increased frequency of symptoms among the staff. The National Health Service should be aware of the fact that non-specific symptoms such as headache and abnormal tiredness can be the result of unfavorable indoor climate conditions due to the presence of formaldehyde in building materials.
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PMID:Formaldehyde induced symptoms in day care centers. 709 Sep 90

Development of the fatigue state in rats, subjected to prolonged alcohol intoxication, after swimming with might led to dissimilar alterations in the system of ammonia formation and binding in brain and spinal cord as compared with control animals under the same conditions of loading. Within the first minutes of the heavy loading the faster and more distinct accumulation of ammonia was observed, then the rapid exhaustion of the reaction occurred and the ammonia production was markedly decreased in the state of fatigue. Impairments in brain protein deamidation and decrease in content of urea were found. At the same time, dynamics of gamma-aminobutyric acid, dicarboxylic amino acids and their amides was altered.
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PMID:[Brain and spinal cord nitrogen metabolism in chronic alcoholism following strenuous physical exertion]. 719 7

A cross-sectional survey of inpatient palliative care subjects (n = 52) was performed to determine the severity and distribution of symptoms thought to be associated with dehydration in terminally ill cancer patients and to clarify the association between the severity of these symptoms and commonly used objective measures of dehydration. Each patient rated the severity of seven symptoms using 100-mm visual analogue scales. The symptoms considered were thirst, dry mouth, bad taste, nausea, pleasure in drinking, fatigue, and pain. Associations were sought between these symptoms and predictor variables (fluid intake, plasma osmolality, sodium, and urea) and confounding variables (age, medications, oral disease, and mouth-care regimen). Mean symptom ratings were thirst 53.8 mm, dry mouth 60.0 mm, bad taste 46.6 mm, nausea 24.0 mm, pleasure in drinking 61.6 mm, fatigue 61.8 mm, and pain 33.5 mm. Using multiple-linear regression, no association could be demonstrated between thirst (the principal outcome of interest) and the predictor or confounding variables. Estimates of the study power performed after completion revealed a 76% chance of detecting a 20-mm difference between high and low fluid intake groups. This study provides the first quantitative estimate of the experience of dehydration symptoms in those with advanced cancer. The symptoms appear to be rated moderately severe, but there is no demonstrable association between severity and fluid intake. Further studies with greater statistical power and more accurate hydration assessment would strengthen our understanding of this association.
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PMID:Dehydration symptoms of palliative care cancer patients. 752 78

Our objective was to assess the effects of increased propionate supply on gut and liver function in lactating cows. Four multicatheterized, primiparous cows (30.4 +/- .5 kg/d of milk) were fed for ad libitum intake a diet of 50% alfalfa hay and 50% concentrate (20.6 +/- 1.9 kg/d of DM, 226 +/- 21 MJ/d of metabolizable energy, and 611 +/- 56 g/d of N). Each cow received intramesenteric infusions of NaCl (control) or Na-propionate (150 mmol/h of a 2.5 M solution) in a reversal design. After 72 h of infusion, blood flow (by indicator dilution) and net flux (venoarterial differences multiplied by blood flow) were measured across portal-drained viscera and the liver. Energy supply from feed consumed and from infusion was similar between treatments. Energy that was excreted as milk decreased with propionate infusion. Propionate infusion increased arterial concentration of propionate; decreased absorption of acetate, butyrate, and valerate; and decreased hepatic removal of L-lactate, butyrate, valerate, NEFA, and oxygen. Propionate infusion decreased splanchnic release of glucose and increased splanchnic release of acetate and alanine. Net flux of urea, BHBA, insulin, or glucagon was unaffected by treatments. Our data show a link between a greater proportion of energy supplied as propionate and decreased energy excreted as milk. This response was associated with decreased net removal of glucogenic and ketogenic substrates by the liver and increased supply of acetate for use by peripheral tissues.
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PMID:Effect of mesenteric vein infusion of propionate on splanchnic metabolism in primiparous Holstein cows. 781 5


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