Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During 25 years 1,702 women with 17,228 cycles under oral contraceptive were observed. This report covers 1,021 women with 11,648 cycles and the frequency of side-effects. The acceptability of OC's is more and more dominated by the side-effects. All subjective symptoms were asked for and not--as usually done--just noted when the woman complained spontaneously. For objective results the bleeding calendar was controlled for amenorrhea, spottings and break-through bleedings. Lowering the ethinylestradiol dose below 50 micrograms (with monophasic OCs, micropills) resulted in a worse cycle control as far as bleeding and silent menstruation were concerned. The genuine normophasic method showed generally a far better cycle control. Combining this method with a new gestagen (Desogestrel) resulted a still better cycle control, especially with amenorrhea. The events of nervosity, gastrointestinal disturbances, changes of libido and fatigue were also less frequent with this OC (Ovidol-Oviol).
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PMID:[Side effects of hormonal contraception. Experiences with 1,702 patients and 17,228 cycles]. 296 81