Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Intracellular pH of in vitro diaphragm preparations was determined following low- (5 Hz, 1.5 min) and high- (75 Hz, 1 min) frequency stimulation, using glass microelectrodes of the liquid membrane type (pHm). Results were compared with values obtained by the standard homogenate technique (pHh). High- and low-frequency stimulation reduced peak tetanic tension to 21 +/- 1 (SE) and 71 +/- 2% of initial values, respectively. Peak tetanic tension returned to resting values after 10- to 15-min recovery from high- or low-frequency stimulation. Resting pHm was 7.063 +/- 0.011 (n = 72), and after fatiguing stimulation declined to values as low as 6.33. During recovery pHm significantly increased and by 10 min had returned to prefatigue values. No difference was observed in the recovery of pHm between the low- and high-frequency stimulation groups (analysis of variance test, ANOVA), and in both groups pHm recovery was highly correlated to the recovery of peak tetanic tension (r = 0.94, P less than 0.001). Resting pHh was 7.219 +/- 0.023 (n = 13), which was significantly higher than the pHm value. In contrast to pHm, intracellular pHh was significantly higher during recovery from 75- vs. 5-Hz stimulation (P less than 0.05). For both groups pHh increased significantly with time and by 10 min returned to prestimulation values. The ANOVA test demonstrated that pHh values were significantly higher than pHm values during recovery from fatigue. The results from this study support our hypothesis that fatigue from both high- and low-frequency stimulation is at least partially due to the deleterious effects of intracellular acidosis on excitation-contraction coupling.
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PMID:Role of intracellular pH in muscle fatigue. 359 14

The purpose of this study was to investigate the effects of caffeine on maximum voluntary contractions of the dominant knee extension and flexion muscles in 12 male intercollegiate track sprinters. Caffeine (5 mg.kg-1) and placebo (225 mg methylcellulose) gelatin capsules were administered orally in randomly assigned order. Muscle function was measured isokinetically by a Cybex II dynamometer interfaced with a data reduction computer. Six repetitions maximum of the extensors and flexors were performed at three sequential ordered speeds (30 degrees, 150 degrees and 300 degrees s-1) with a one-minute rest between varying velocities. Peake torque and power were than assessed after treatment conditions, as well as a fatigue index calculated from a series of 60 repetitions maximum ato 150 degrees s-1. Results of the 2 X 3 ANOVA and paired t-test indicated no difference in measures of peak torque and power at the varying contracting velocities and fatigue index after caffeine ingestion. These findings indicate the ingestion of caffeine in a small dose exerts no ergogenic effect on muscle function under anaerobic conditions.
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PMID:Caffeine ingestion and isokinetic strength. 377 43

Eight elite junior oarsmen (ER) and sixteen club level rowers (CR) were tested for upper body strength (trunk, arms) and for mean, peak and minimum power outputs using the Double-Arm Anaerobic Work Test (DAAWT). This test is a modified version of the original Wingate test whereby athletes can be tested using trunk and both arms simultaneously. Multiple Discriminant Analysis was used to determine if the DAAWT variables alone were sensitive enough to discriminate between the two groups. Additionally, Pearson's correlation coefficients and ANOVA were employed. Results indicate that mean power and power difference expressed in absolute values (Watts) could successfully classify junior oarsmen into appropriate groups (91.8%, P less than 0.001). In addition, there was a fairly high correlation (r = 0.81) between mean power and strength in the ER. The strongest ER demonstrated the least fatigue while highly significant differences between the groups in most of the other variables examined have also been demonstrated.
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PMID:A modified Wingate test for measuring anaerobic work of the upper body in junior rowers. 381 83

This study illustrated the relationship between swimming, an aerobic activity, and mood. One hundred college students, voluntarily enrolled in beginning or intermediate swimming classes or in lecture-control classes, completed the POMS before and after class. Results of a 5-way ANOVA confirmed that, as predicted, swimmers reported significantly less tension, depression, anger, confusion, and more vigor after exercising than before. Both novice and intermediate swimmers changed significantly more than did controls on all scales except fatigue, while none of the controls' pre-, post-instruction mood changes were significant. The results have implications, similar to those with running, for use in psychotherapy. Despite different social connotations of exercise for women and men, there were no gender differences in the amount of mood change associated with swimming. However, in direct contradiction of existing literature, the women reported significantly less tension-anxiety, depression, anger, and confusion than the men.
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PMID:Mood alteration with swimming--swimmers really do "feel better". 663 5

The purpose of this investigation was to compare the thresholds of neuromuscular fatigue determined simultaneously from the vastus lateralis (VL), vastus medialis (VM) and rectus femoris (RF) muscles using the electromyographic fatigue threshold (EMGFT) test. Eight adult volunteers [mean (SD) age, 33 (10) years] served as subjects for this investigation. The results of a one-way repeated measured ANOVA indicated that there was a significant (P < 0.05) difference among the mean EMGFT values for the VL [248(31)W], VM [223(43)W] and RF [220(30)W] muscles. Tukey post-hoc comparisons indicated that the EMGFT for the RF was significantly (P < 0.05) lower than that of the VL. These findings suggested that during cycle ergometry there is a dissociation in neuromuscular fatigue characteristics of the superficial muscles of the quadriceps femoris group.
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PMID:Electromyographic fatigue thresholds of the superficial muscles of the quadriceps femoris. 758 79

The purpose of this study was to evaluate the effect of the beta 2-agonist albuterol (salbutamol) at twice the normal dosage (360 micrograms) on power output during a 30-second Wingate test and pulmonary function in highly trained cyclists (4 category 1 and 10 category II U.S.C.F. track cyclists). The cyclists did not have a history of exercise induced bronchial spasms, and a 5 step methacholine challenge confirmed all subjects to be non-asthmatic. The project was performed in a random block, double blind design. Twenty minutes before the 30-second Wingate cycle ergometer exercise, albuterol (90 micrograms per dose) or a saline placebo was administered by inhaler in 4 metered doses. Pulmonary function tests were performed at rest, 20 minutes post-inhalation, and 5, 10, 15 minutes post-exercise. After a standard warm-up, a 30-second Wingate anaerobic power test was performed on a cycle ergometer at a resistance of 0.10 kg (kg body mass)-1. Multi-variate ANOVA revealed no significant difference between the albuterol and placebo treatment for the anaerobic power measures: peak power (1,136.7 +/- 40.9 vs 1,124.8 +/- 39.8 W, mean +/- s.e.), total work (27,213.6 +/- 653.1 vs 27,093.3 +/- 677.4j), time to peak power (4.5 +/- 0.2 vs 4.8 +/- 0.5 s), and fatigue index (16.5 +/- 1.8 vs 16.6 +/- 1.8 W.s-1). Peak heart rate (181.6 +/- 3.7 vs 181.4 +/- 3.8 bpm), or blood lactate (14.0 +/- 0.9 vs 13.8 +/- 0.8 mmol.l-1) 3 min after the exercise bout were not significantly different between treatments.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:The effects of albuterol on power output in non-asthmatic athletes. 765 18

Physiological responses were compared in nine stable male cardiac patients (mean +/- standard error (SE): age, 68.3 +/- 8.1 years; height, 172.7 +/- 3.9cm; weight, 72.8 +/- 14.5kg) during stationary cycling in the supine, recumbent, and upright positions. A discontinuous exercise protocol was performed in which each stage included 3 minutes of exercise and 1 minute of recovery. Each subject's workload started at 150kgm.min-1 and increased by 150kgm.min-1 per stage until volitional fatigue. Testing sessions were randomized and performed 1 week apart. Subjects continued their normal medication regimen. All subjects were participants in a community-based cardiac rehabilitation program. Dependent variables were assessed at two different intensities; submaximal (300kgm.min +/- 1) and maximal. A two-way repeated measures ANOVA found no significant differences in systolic blood pressure (SBP), diastolic blood pressure (DBP), minute ventilation (VE), respiratory exchange ratio (R), rate pressure product (RPP), and rating of perceived exertion (RPE) at submaximal (300kgm.min +/- 1) and maximal exercise efforts. Heart rate (HR) was significantly lower (p < or = .05) in the supine position compared with either the upright or recumbent positions during the submaximal workload. In addition, oxygen uptake (VO2) was significantly lower in the supine position at the submaximal workload (p < or = .05) compared with both upright and recumbent. No difference in HR or VO2 was observed at maximal exercise. Regressions of HR on VO2 showed similar slopes and intercepts for supine, recumbent, and upright ergometry.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Physiologic responses of cardiac patients to supine, recumbent, and upright cycle ergometry. 771 19

Tethered swimming forces (TSF), average distance achieved per stroke (D/S) during a submaximal effort swim, and time and D/S for a maximal effort swim were measured to determine changes occurring with staleness and recovery. Fourteen nationally ranked male and female swimmers were studied five times (i.e. early-, mid-, and late-season, during tapering, and after competition). ANOVA and Newman-Keuls post-hoc tests were used to assess changes during the season. Three swimmers were classified as stale and showed a deterioration (0.7%) in maximal performance time from early- to late-season which was significantly different (P < 0.05) from the improvement (3.1%) demonstrated by the non-stale swimmers. Daily self-ratings of fatigue, kept by the swimmers in log books during the season, were significantly higher (P < 0.001) for the stale compared with the non-stale swimmers. No significant differences were established between the stale and non-stale swimmers in TSF or D/S during the season or in the response to tapering. A significant improvement (P < 0.05) in TSF was observed from before to after tapering. It was concluded that TSF and D/S may not change significantly with staleness and that the recovery period of tapering prior to competition allows swimmers to generate greater forces in the water.
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PMID:Biomechanical responses of elite swimmers to staleness and recovery. 778 Jul 75

The validity of a patient-based scale, presumably measuring adverse effects of drugs on cognitive function, was examined in a normal volunteer study. Thirty subjects were randomly assigned to placebo or one of two doses of a benzodiazepine, temazepam (10 mg and 20 mg), in a double-blind placebo-controlled parallel group design. Plasma samples were taken before the scale was completed and up to 8 hours post-dose. After administration of the medication the subjects were asked to maintain their normal daily routine as much as possible (reading, studying, conversations). The inventory was administered twice, at 50 minutes and 2 hours post-dose (peak level). The overall score was different between the three groups, only for the second assessment, 2 h post-dose (ANOVA, P < 0.02). Multiple t-testing between the three groups revealed statistically significant differences between placebo and the 10 mg temazepam group (P = 0.02) and between placebo and the 20 mg temazepam group (P = 0.006). No significant difference was found between the two temazepam groups. Analysis of the separate questions showed least sensitivity for questions related to the domain of 'hyperexcitability' and most sensitivity for 'fatigue' and 'slowing.' The overall score appeared to be sensitive already for the lower toxicity range suggesting an 'all or nothing effect'. The subjective reports, collected by using this scale, may therefore be used for the detection of gross overall changes in cognitive functioning.
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PMID:The Neurotoxicity Scale: the validity of a patient-based scale, assessing neurotoxicity. 779 95

The present study was designed to characterize and assess the reliability of acute mood responses to maximal exercise in women. All subjects (N = 22; age = 45 +/- 2.5 yr; BMI = 24.3 +/- 0.9 kg/m2) participated in two maximal walking tests spaced approximately one month apart. The abbreviated Profile of Mood States (POMS) questionnaire was administered immediately prior to and within 5 min following maximal exercise at both occasions. Maximal heart rate, rating of perceived exertion, and functional aerobic capacity responses indicated compliance to maximal exertion at both tests. Using repeated measures ANOVA, no significant (p < .05) differences were noted between the two tests for any of the POMS subscales. Significant pre to postexercise increases were noted for fatigue and self-esteem subscales while the tension and vigor affects significantly decreased. Because no interactions were found, these effects are concluded to be independent of the order in which the tests were performed. Additionally, intraclass correlations computed for each respective POMS subscale, ranged between 0.69 and 0.81 for fatigue, tension, vigor, self-esteem, confusion, and total mood disturbance. The anger and depression subscales were noted to have intraclass correlations of 0.29 and 0.43, respectively, and may have been influenced by a floor effect in this study population. It is concluded that the abbreviated POMS questionnaire may be reliably used to assess acute mood responses to maximal exercise in women and that even maximal exertion has the potential to acutely benefit mood by decreasing tension and increasing self-esteem.
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PMID:Maximal exercise and acute mood response in women. 787


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