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 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The efficacy and agreeability of a supportive drug therapy at doses of 300 mg of proquazone (Biarison) administered thrice daily was tested in an open study of 4 weeks' duration in 10 male patients suffering of clinically verified ankylosing spondylitis. The minimum duration of suffering was 15 years, the maximum 50 years. The major goal of therapy during clinical treatment was individually oriented physical therapy suited to the enhancement of residual mobility, removal of postural abnormalities and abnormalities of weight-loading as well as the maintenance of functionality for afflicted skeletal regions. In the course of this additional therapy with proquazone the functional index and activity index both displayed significant improvement (2 p less than 0.01), as compared with the control subjects. Improvement was attained as soon as 2 weeks following begin of therapy. In the course of treatment the following parameters also displayed significant improvement (2 p less than 0.05): morning stiffness, fatigue, patient's self-evaluation, Westergren one-hour-value, physician's over-all assessment, night pain, articular pain, thoracic and lumbar pain. There were only insignificant changes in other, regularly tested laboratory values during this drug therapy. No side effects or disagreeability signs of proquazone were noted. Proquazone can be recommended for the symptomatic additional treatment of patients suffering from ankylosing spondylitis.
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PMID:[Ankylosing spondylitis. Pathogenesis and therapy]. 722 33

The aim of this study was to measure and compare the ultimate failure strengths and cyclic fatigue strengths of currently available meniscal suturing devices. No statistically significant difference in failure load was found between a vertical loop suture (mean 46.3 N), a horizontal mattress suture (52.5 N), the T-fix Device (47.5 N), and the 16-mm (39.2 N) and 13-mm (32.8 N) Bionix Arrow. Statistically inferior results were seen with the 10-mm Bionix Arrow (18.8 N), the S.D. Sorb Stapler (4.3 N), and the 12-mm Arthrex Meniscal Dart (10.5 N) (P<0.01). The Mitek Meniscal Repair System (28.1 N) performed intermediate, with significantly better results than the S.D. Sorb Stapler and the 12-mm Arthrex Dart, but significantly worse than the vertical and horizontal sutures, the T-fix and Bionix 16-mm Device (P<0.01). Cyclic fatigue strength was significantly less for the 10-mm Bionix Arrow, the S.D. Sorb Stapler, and the 12-mm Arthrex Meniscal Dart (P<0.01) compared to all other devices. We conclude that the 13- and 16-mm Bionix Arrow and the T-fix Device have comparable ultimate failure strengths and cyclic fatigue strengths to conventional meniscal suturing techniques. The 10-mm Bionix Arrow, S.D. Sorb Stapler, and the 12-mm Arthrex Meniscal Dart, however, have far inferior failure and cyclic fatigue strengths and their clinical application should be questioned.
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PMID:Fixation strength of meniscal repair devices. 1183 Mar 75

Our aim was to identify alternative suture materials that might provide superior knot performance and equivalent ease of manipulation by means of an in vitro experimental study. Although used widely for arthroscopic shoulder stabilisation, absorbable poly( p-dioxanone) (PDS) monofilament sutures can lead to dehiscence and clinical failure due to knot slippage and/or loop elongation at low applied loads. With the objective of identifying alternative suture materials that might provide superior knot performance and equivalent ease of manipulation, an in vitro experiment was undertaken in which both Duncan and Snyder knotted loops were tied from four different suture materials using an arthroscopic knot pusher (Surgeon's 6th Finger) and a wooden practice box (Arthrex). Three monofilament sutures, made from polypropylene (PROLENE), poly(glycolidetrimethylenecarbonate-co-dioxanone) (Biosyn) and PDS, and one braided polyester suture (SURGIDAC) were tested. Ease of manipulation was evaluated by measuring the time required to tie the knots, and the knot performance was assessed in terms of loop elongation and loop holding capacity by performing cyclic fatigue testing of the loops while they were immersed in saline on an INSTRON mechanical tester. The PROLENE and SURGIDAC sutures showed improvements in loop elongation and loop holding capacity over PDS, with the Snyder knots being consistently superior to Duncan knots. BIOSYN gave no improvement over PDS. Difficulties were encountered in advancing half-hitch throws of the braided SURGIDAC suture down the cannula, which resulted in longer knotting times. In conclusion, both the polypropylene and polyester sutures gave superior knot performance to PDS, but only the polypropylene gave equivalent ease of manipulation. As a result there may be clinical advantages in replacing PDS with monofilament polypropylene or braided polyester sutures for certain arthroscopic procedures.
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PMID:Comparative study of knot performance and ease of manipulation of monofilament and braided sutures for arthroscopic applications. 1511 14

The goal of this study was to determine whether a difference in cycles to failure or mode of failure would be observed among specimens of 3 high-strength suture materials, and whether different suture configurations would affect knot security. Ten representative specimens of Ethibond (Ethicon, Inc, Somerville, New Jersey), FiberWire (Arthrex, Inc, Naples, Florida), MaxBraid (Biomet, Inc, Warsaw, Indiana), and Orthocord (DePuy Orthopaedics, Warsaw, Indiana) were tied in 6 different knot configurations commonly used in orthopedic procedures. Each specimen was cyclically loaded between 9 and 180 N at a rate of 1 Hz until the specimen failed or reached a maximum of 3500 cycles. Each suture material was subjected to tensile loading until failure at a rate of 1.25 mm/s. The 3 most secure knots all included the 3 reverse half-hitch on alternating posts (3-RHAP) configuration. All specimens tied with these 3 knot types failed by suture rupture. All knots using the overhand with 3 of the same half-hitches on the same post (O-3SHSP) configuration failed by knot slippage regardless of suture material. When the 3 strongest knots were combined, FiberWire resisted a significantly greater number of fatigue cycles than Orthocord or MaxBraid. In the single load to failure tests, Orthocord, FiberWire, and MaxBraid all had significantly higher ultimate strength than Ethibond. Knots using the 3-RHAP configuration provide security superior to that of those without this configuration. All 3 high-strength sutures tested outperformed Ethibond in single load to failure testing, with FiberWire resisting the greatest number of cycles. Postoperative strength and reliability of a soft tissue repair is inherently dependent on the properties of the suture materials used.
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PMID:Evaluation of high-strength orthopedic sutures: a head-to-head comparison. 2083 7