Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fenoprofen calcium (FC) was compared to aspirin (ASA) in 20 patients with rheumatoid arthritis in a double-blind parallel study. The average daily dose was 2.0 gm of FC, or 3.6 gm of ASA. Most patients on FC therapy responded similarly to those receiving ASA, but FC was slightly better in reducing morning stiffness, walking time, fatigue severity, and activity index. More FC treated than ASA treated patients became worse when placebo was substituted after one year of therapy, with a greater increase in the number and severity of painful and swollen joints, in addition to the above mentioned parameters. This suggests a greater suppression of the inflammatory process during FC therapy. FC was well tolerated and had a greater antirheumatic effect than aspirin. Both drugs were superior to placebo.
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PMID:Fenoprofen calcium therapy in rheumatoid arthritis. 78 Dec 26

Bilateral pulmonary infiltrates developed in a 77-year-old woman. These were associated with chills, fatigue, a high spiking temperature, leukocytosis, and eosinophilia. Clinical symptoms abated after 24 hours, and radiologic abnormalities cleared several days after discontinuing Nalfon, plus administering prednisone. The most likely cause of these pulmonary infiltrates was a hypersensitivity or idiosyncratic reaction to Nalfon.
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PMID:Pulmonary hypersensitivity to nalfon. 375 22