Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this study was to investigate kinematic and kinetic changes as a result of extended play in baseball pitching. Seven major league baseball pitchers were videotaped with high-speed (120 Hz) cameras during multiple innings of the same game. For each athlete, two fastballs (one thrown during the initial inning of play and one from the final inning) were chosen for analysis. Twenty-one physical landmarks were manually digitized from the video data. Kinematic and kinetic parameters were subsequently calculated relative to four phases of the pitching motion: windup, cocking, acceleration, and follow-through. Paired t-tests revealed that seven parameters changed significantly between early and late innings. These included decreases in maximum external rotation of the shoulder, knee angle at ball release, ball velocity, maximum distraction force at both the shoulder and elbow, and horizontal adduction torque at both release and its maximum value. Ultimately, a decline in performance was evident by a 2 m/s (5 mph) drop in ball speed. It is unclear whether the kinematic and kinetic changes occurred because of fatigue or if protective mechanisms were adopted.
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PMID:The effects of extended play on professional baseball pitchers. 1129 37

Road traffic crashes (RTCs) are responsible for a substantial fraction of morbidity and mortality and are responsible for more years of life lost than most of human diseases. In this review, we have tried to delineate behavioral factors that collectively represent the principal cause of three out of five RTCs and contribute to the causation of most of the remaining. Although sharp distinctions are not always possible, a classification of behavioral factors is both necessary and feasible. Thus, behavioral factors can be distinguished as (i) those that reduce capability on a long-term basis (inexperience, aging, disease and disability, alcoholism, drug abuse), (ii) those that reduce capability on a short-term basis (drowsiness, fatigue, acute alcohol intoxication, short term drug effects, binge eating, acute psychological stress, temporary distraction), (iii) those that promote risk taking behavior with long-term impact (overestimation of capabilities, macho attitude, habitual speeding, habitual disregard of traffic regulations, indecent driving behavior, non-use of seat belt or helmet, inappropriate sitting while driving, accident proneness) and (iv) those that promote risk taking behavior with short-term impact (moderate ethanol intake, psychotropic drugs, motor vehicle crime, suicidal behavior, compulsive acts). The classification aims to assist in the conceptualization of the problem that may also contribute to behavior modification-based efforts.
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PMID:Human factors in the causation of road traffic crashes. 1129 24

This study examined the effects of a virtual reality distraction intervention on chemotherapy-related symptom distress levels in 16 women aged 50 and older. A cross-over design was used to answer the following research questions: (1) Is virtual reality an effective distraction intervention for reducing chemotherapy-related symptom distress levels in older women with breast cancer? (2) Does virtual reality have a lasting effect? Chemotherapy treatments are intensive and difficult to endure. One way to cope with chemotherapy-related symptom distress is through the use of distraction. For this study, a head-mounted display (Sony PC Glasstron PLM - S700) was used to display encompassing images and block competing stimuli during chemotherapy infusions. The Symptom Distress Scale (SDS), Revised Piper Fatigue Scale (PFS), and the State Anxiety Inventory (SAI) were used to measure symptom distress. For two matched chemotherapy treatments, one pre-test and two post-test measures were employed. Participants were randomly assigned to receive the VR distraction intervention during one chemotherapy treatment and received no distraction intervention (control condition) during an alternate chemotherapy treatment. Analysis using paired t-tests demonstrated a significant decrease in the SAI (p = 0.10) scores immediately following chemotherapy treatments when participants used VR. No significant changes were found in SDS or PFS values. There was a consistent trend toward improved symptoms on all measures 48 h following completion of chemotherapy. Evaluation of the intervention indicated that women thought the head mounted device was easy to use, they experienced no cybersickness, and 100% would use VR again.
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PMID:Virtual reality intervention for older women with breast cancer. 1285 87

The paper presents a theoretical analysis of possible effects of reverberation time on the cognitive load in speech communication. Speech comprehension requires not only phonological processing of the spoken words. Simultaneously, this information must be further processed and stored. All this processing takes place in the working memory, which has a limited processing capacity. The more resources that are allocated to word identification, the fewer resources are therefore left for the further processing and storing of the information. Reverberation conditions that allow the identification of almost all words may therefore still interfere with speech comprehension and memory storing. These problems are likely to be especially serious in situations where speech has to be followed continuously for a long time. An unfavourable reverberation time (RT) then could contribute to the development of cognitive fatigue, which means that working memory resources are gradually reduced. RT may also affect the cognitive load in two other ways: RT may change the distracting effects of a sound and a person's mood. Both effects could influence the cognitive load of a listener. It is argued that we need studies of RT effects in realistic long-lasting listening situations to better understand the effect of RT on speech communication. Furthermore, the effect of RT on distraction and mood need to be better understood.
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PMID:Effects of reverberation time on the cognitive load in speech communication: theoretical considerations. 1570 45

A retrospective population-based case-control study was conducted to determine whether driver sleepiness/fatigue and inattention/distraction increase the likelihood that a commercial motor vehicle collision (CVC) will be fatal. Cases were identified as CVC drivers who died (fatal) and controls were drivers who survived (nonfatal) an injury collision using the Kentucky Collision Report Analysis for Safer Highways (CRASH) electronic database from 1998-2002. Cases and controls were matched on unit type and roadway type. Conditional logistic regression was performed. Driver sleepiness/fatigue, distraction/inattention, age of 51 years of age and older, and nonuse of safety belts increase the odds that a CVC will be fatal. Primary safety belt law enactment and enforcement for all states, commercial vehicle driver education addressing fatigue and distraction and other approaches including decreased hours-of-service, rest breaks and policy changes, etc. may decrease the probability that a CVC will be fatal.
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PMID:Sleepiness/fatigue and distraction/inattention as factors for fatal versus nonfatal commercial motor vehicle driver injuries. 1592 53

Catalepsy tests performed in rodents treated with drugs that interfere with dopaminergic transmission have been widely used for the screening of drugs with therapeutic potential in the treatment of Parkinson's disease. The basic method for measuring catalepsy intensity is the "standard" bar test. We present here an easy to use microcontroller-based automatic system for recording bar test experiments. The design is simple, compact, and has a low cost. Recording intervals and total experimental time can be programmed within a wide range of values. The resulting catalepsy times are stored, and up to five simultaneous experiments can be recorded. A standard personal computer interface is included. The automated system also permits the elimination of human error associated with factors such as fatigue, distraction, and data transcription, occurring during manual recording. Furthermore, a uniform criterion for timing the cataleptic condition can be achieved. Correlation values between the results obtained with the automated system and those reported by two independent observers ranged between 0.88 and 0.99 (P<0.0001; three treatments, nine animals, 144 catalepsy time measurements).
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PMID:A novel automated rat catalepsy bar test system based on a RISC microcontroller. 1593 23

More than two out of three of all fatal crashes in Maine occur on rural, two-lane collector or arterial roads. Head-on crashes on these roads account for less than 5% of the crashes, but they are responsible for almost half of all fatalities. Data analyzed in this study was provided by Maine Department of Transportation and covers all head-on crashes for 2000-2002 during which period there were 3,136 head-on crashes reported. Out of these, 127 were fatal crashes and 235 produced incapacitating but not fatal injuries. These two categories made up over 75% of the crash cost. A clear majority of head-on crashes on two-lane, rural roads in Maine were caused by drivers making errors or misjudging situations. Illegal/unsafe speed was a factor in 32% of the crashes while driver inattention/distraction was a primary factor in 28%. Fatigue was responsible for around one in 40 crashes and one in 12 fatal crashes. Alcohol or drugs was a factor in one in 12 crashes and one in nine fatal head-on crashes. Less than 8% of fatalities involved someone overtaking another vehicle, and only around 14% involved a driver intentionally crossing the centerline. Two in three fatal head-on crashes occurred on straight segments and 67% of these happened on dry pavement. There is a clear trend towards higher speed limits leading to a higher percentage of crashes becoming fatal or having incapacitating injuries. There is also a clear trend - if one keeps speeds constant and AADT within a certain range - that wider shoulders give higher crash severities. Also, for higher-speed roads, more travel lanes (than two) increase crash severity. In summary, there seems to be two major reasons why people get across the centerline and have head-on collisions: (a) people are going too fast for the roadway conditions; or (b) people are inattentive and get across the centerline more or less without noticing it. The latter category of crashes could probably be reduced if centerline rumble-strips were installed. More or less all head-on collisions could be eliminated if median barriers were installed. In-vehicle technology could also be used to significantly reduce the incidence of lane departures. Furthermore, today's speed limits should be better enforced since a high percentage of serious crashes involve illegal speeding. This should be combined with lowered speed limits for targeted high-crash segments.
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PMID:Segment characteristics and severity of head-on crashes on two-lane rural highways in Maine. 1642 19

The survivor uncertainty management intervention study is a randomized controlled study designed to test the efficacy of an intervention that combines training in audiotaped cognitive behavioral strategies to manage uncertainty about cancer recurrence with a self-help manual designed to help women understand and manage long-term treatment side effects and other symptoms. Specifically, women were taught to recognize their own personal triggers of uncertainty (places, events or surroundings, that bring back memories, feelings, or concerns about breast cancer), and then use coping skills such as relaxation, distraction, and calming self-talk to deal with uncertainty. Also, women were taught to use the manual as a resource for dealing with fatigue, lymphedema, pain and other symptoms. Treatment outcome data (Mishel et al., in press) indicated that the uncertainty management intervention resulted in improvements in cognitive reframing, cancer knowledge, social support, knowledge of symptoms and side effects, and coping skills when compared to a control condition. The purpose of the present paper was to report on the use and helpfulness of the intervention components by the 244 women who were in the intervention. Findings indicated that women regularly used the intervention components to deal with triggers of breast cancer recurrence and long-term treatment side effects and most women found the strategies very helpful.
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PMID:Uncertainty management intervention for older African American and caucasian long-term breast cancer survivors. 1649 49

Symptom monitoring by parents/caregivers of children with cancer and what the caregiver and child did to help alleviate symptoms during chemotherapy were studied. The Therapy-Related Symptom Checklist (TRSC) child version was administered to parents/caregivers of 11 children and adolescents (mean age, 10.4 years; SD, 6.1 years; range, 2-18 years; 45% were boys). The Karnofsky scale was completed by clinicians to rate the child's functional status. The TRSC child version and functional status scores were inversely related. All children experienced nausea; the most frequent symptoms reported were in TRSC subscales: fatigue, nausea, eating, fever, oropharynx, pain, and hair loss. Care strategies that helped were distraction, massage, mouth rinses, and vitamins; some reported that their child received medications for pain, nausea, and vomiting. Using complementary medicine categories, the care strategies were diet/nutrition/lifestyle change (eg, more high-fat, high-calorie foods; new foods; any food the child likes; and much sleep and rest); mind/body control (eg, play, video games, television, reading, activity puzzle, breathing exercises, relaxation methods, and prayer); manual healing method (massage and skin-to-skin contact); and biologic treatments (vitamins). The first 2 categories were the most used. Systematic assessment with a self-report checklist enables the provider to identify and prioritize (according to reported severity) those symptoms needing intervention.
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PMID:Symptom monitoring and dependent care during cancer treatment in children: pilot study. 1678 17

Tourette syndrome is a neurodevelopmental disorder characterized by motor and vocal tics--rapid, repetitive, stereotyped movements or vocalizations. Tourette syndrome typically has a prepubertal onset, and boys are more commonly affected than girls. Symptoms usually begin with transient bouts of simple motor tics. By age 10 years, most children are aware of nearly irresistible somatosensory urges that precede the tics. These urges likely reflect a defect in sensorimotor gating because they intrude into the child's conscious awareness and become a source of distraction and distress. A momentary sense of relief typically follows the completion of a tic. Over the course of hours, tics occur in bouts, with a regular intertic interval. Tics increase during periods of emotional excitement and fatigue. Tics can become "complex" in nature and appear to be purposeful. Tics can be willfully suppressed for brief intervals and can be evoked by the mere mention of them. Tics typically diminish during periods of goal-directed behavior, especially those that involve both heightened attention and fine motor or vocal control, as occur in musical and athletic performances. Over the course of months, tics wax and wane. New tics appear, often in response to new sources of somatosensory irritation, such as the appearance of a persistent vocal tic (a cough) following a cold. Over the course of years, tic severity typically peaks between 8 and 12 years of age. By the end of the second decade of life, many individuals are virtually tic free. Less than 20% of cases continue to experience clinically impairing tics as adults. Tics rarely occur in isolation, and other coexisting conditions--such as behavioral disinhibition, hypersensitivity to a broad range of sensory stimuli, problems with visual motor integration, procedural learning difficulties, attention-deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder, depression, anxiety, and emotional instability--are often a greater source of impairment than the tics themselves. Emerging behavioral treatments of Tourette syndrome are based in part on an understanding of the moment-to-moment experience of somatosensory urges and motor response. With identification of specific genes of major effect and advances in our understanding of the neural circuitry of sensorimotor gating, habit formation, and procedural memory--together with insights from postmortem brain studies, in vivo brain imaging, and electrophysiologic recordings--we might be on the threshold of a deeper understanding of the phenomenology and natural history of Tourette syndrome.
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PMID:Tourette syndrome: the self under siege. 1697 Aug 64


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