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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One-arm cranking was done by ten healthy male adults at an oxygen intake level of about 1.0 liter/min. Each subject performed two kinds of cranking at a speed of 60 rpm: forced cranking using only one arm continuously for 15 min and free cranking for 30 min with the instructions to alternate from one arm to the other whenever fatigue set in. The results, excluding those of a subject who changed arms very frequently, were analyzed. In forced cranking, oxygen intake and heart rate steadily increased, the average time of appearance of local fatigue being 161 sec for the stronger arm and 122 sec for the weaker one. In free cranking, the working arm was changed 6 to 23 times during the 30-minute period, while oxygen intake and heart rate increased with fluctuations. The mean duration interval was 175 sec with the stronger arm and 123 sec with the weaker one. The mean interval of arm alternation was positively correlated with the individual time of onset of the sensation of local rigidness during forced cranking, but not with the individual time of initiation of respiratory distress. It is suggested that alternation of active muscles in moderately dynamic work may be linked with an early stage of local fatigue which is different from that of static work.
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PMID:Spontaneous alternation of the working arm in one-arm cranking. 103 Jul 31

A 74-year-old housewife was admitted to the hospital with complaints of high fever and general fatigue. The physical examinations on admission showed no particular findings except for mild hepatomegaly, but laboratory findings showed severe liver dysfunction, active inflammation and negative tuberculine test. On the 4th day, she suddenly complained of severe respiratory distress. A chest X-ray film demonstrated surprising changes in comparison with that taken on admission. On suspicion of adult respiratory distress syndrome (ARDS) associated with military tuberculosis (Miliary TB), administration of Methylpredonisolone (1000 mg a day for 3 days) in addition to antituberculous drugs was immediately started. With this therapy she was recovered from such ill condition, but the general exhaustion and slight fever continued. We suspected that her condition might be due to adrenocortical involvement of Miliary TB and hormonal examinations were performed. Unexpectedly, Cushing's syndrome was suspected on the basis of the following; high level of plasma cortisol without normal daily variation, normal ACTH level, an absent response to the Dexamethasone suppression test. Computed tomography revealed left side adrenal mass. During these examinations, renal dysfunction probably due to Miliary TB grew gradually worse and she died of renal failure on the 56th day. Necropsy revealed disseminated tuberculosis involving the lungs and the liver, but the adrenal glands were not examined.
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PMID:[A case of miliary tuberculosis (miliary TB) accompanied with adult respiratory distress syndrome (ARDS) in a patient with Cushing's syndrome]. 140 68

Contractile properties of diaphragm (DIA) from mdx and control mice were compared with those of hindlimb muscles [soleus (SOL) and extensor digitorum longus (EDL)] in vitro. Mice ranged in age from 2 weeks to 1.5 years. Muscles were directly stimulated and properties measured were: contraction time, half-relaxation time, active tension per unit area, fatigue index, and maximal velocity of shortening (Vmax). Active tension decreased significantly with age in mdx DIA but not in control DIA. SOL and EDL active tensions were less in mdx than control over the whole age range and did not decrease with age. Vmax was decreased in mdx DIA, but not in mdx SOL or EDL. These results demonstrate that DIA is more affected by muscular dystrophy than hindlimb muscles. Since many Duchenne patients exhibit respiratory distress, this differential expression of dystrophy in diaphragm, as compared to limb muscles, may have important clinical implications.
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PMID:Differential expression of muscular dystrophy in diaphragm versus hindlimb muscles of mdx mice. 140 67

We have conducted a retrospective survey of 79 children out of a total hospital asthmatic patient population of 2,412, admitted over a 32 month period to the ICU for the management of severe status asthmaticus. All patients were in severe respiratory distress with CO2 retention; 19 required mechanical ventilation due to increasing fatigue and worsening bronchospasm, having failed to respond to either inhaled or IV bronchodilator therapy. All patients were ventilated at slow rates (less than 12 min) and their airway pressure (Paw) was deliberately kept below 45 cmH2O, while accepting a PaCO2 in the 45-60 mmHg range, as long as the pH was compensated. Although two patients developed pneumothoraces while on positive pressure ventilation, these were resolved without incidents. Five patients who had mediastinal or subcutaneous air leaks prior to intubation did not develop pneumothoraces. Following the initiation of mechanical ventilation, IV beta-agonist therapy was increased in order to reverse the bronchospasm and reduce the duration of mechanical ventilation. Mean duration of intubation was 42 hours. Fourteen of the 19 patients were weaned and extubated within 48 hours. All patients survived without sequelae. We conclude that a degree of controlled "hypoventilation" by deliberately choosing Paw less than 45 cmH2O can be successfully used to ventilate children with severe status asthmaticus with a reduced rate of pressure-related complications.
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PMID:Efficacy, results, and complications of mechanical ventilation in children with status asthmaticus. 175 29

Diaphragmatic fatigue (DF) in respiratory distress syndrome (RDS) induced by injection of fat were studied in 7 dogs. After injection of fat, all dogs developed respiratory distress and tachypnea, PaO2 fell to the level lower than 8 kPa. Transdiaphragmatic pressure (Pdi) decreased progressively (P less than 0.05-0.001), Pdi-stimulation frequency (Pdi-F) curve shifted to the right, central frequency (Fc), median frequency (Fm) and high/low frequency ratio (H/L) significantly decreased (P less than 0.05-0.001). It is concluded that the contractile force of the diaphragm progressively decreased after RDS was induced, which suggested the occurrence of DF.
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PMID:[Diaphragmatic fatigue in respiratory distress syndrome in dogs]. 181 79

A 62-year-old woman presented with respiratory distress, fatigue, diplopia, and difficulty in swallowing. Liver imaging and CT of the abdomen both revealed an intrahepatic defect (although an angiogram was reported as normal). The patient recalled having had radiation therapy 22 years previously. A review of the record at that time revealed that a thymoma had been present in the mediastinum; it had been irradiated, but not resected. The patient rapidly deteriorated. At autopsy, the hepatic mass represented a metastatic thymoma. The functional nature of the metastatic tumor mass (myasthenic symptoms) was unusual, as was the long latent period after irradiation of the primary.
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PMID:Hepatic mass. Functioning metastatic thymoma 22 years after radiation therapy. 374 12

The purpose of the investigation was to evaluate the effectiveness of trait anxiety in predicting respiratory distress resulting from heavy physical work performed while wearing an industrial respirator. Spielberger's trait anxiety scale was administered to 45 male volunteers in order to identify individuals with elevated trait anxiety. This testing was followed by a pulmonary function test, resting 12-lead electrocardiogram (ECG), and an exercise ECG. Individuals with cardiovascular and/or pulmonary impairment did not continue with subsequent tests. The subjects next completed three treadmill tasks varying in intensity from 35% to 80% of VO2max, and each trial lasted for 10 minutes. Twenty-five of these individuals performed the exercise tasks while wearing a self-contained breathing apparatus (SCBA) in the demand mode, whereas the remaining 20 subjects used a pressure-demand SCBA. The reason for terminating exercise was classified as respiratory or non-respiratory on the basis of self-report responses on a 7-point dyspnea scale, as well as general responses concerning muscular fatigue and respiration. It was predicted, based upon trait anxiety scores, that six individuals would have respiratory distress, and five (83%) of these predictions were correct. It was also predicted that 39 of the 45 subjects would not experience distress and 38 (97%) of these predictions were correct. It was concluded that objective measures of trait anxiety can be used to identify those individuals who are most likely to experience distress while wearing an industrial respirator and performing heavy physical exercise.
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PMID:Prediction of distress for individuals wearing industrial respirators. 388 Jan 89

Since the introduction of ophthalmic timolol solution in 1978 there have been numerous reports of systemic toxicity associated with its use. The majority of the systemic side effects reported are the same as those associated with oral timolol. Several cases of respiratory distress have been described generally in patients with underlying restrictive airway disease. Cardiovascular effects range from effects on resting pulse rate to the development of overt bradycardia and heart failure. Central nervous system effects reported include fatigue, confusion, depression, and hallucinations. A variety of other systemic effects have also been described. Caution should be used when ophthalmic timolol is administered to elderly patients or those patients with contraindications to systemic beta-blockers.
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PMID:Systemic side effects associated with the ophthalmic administration of timolol. 388 77

The contractile, histochemical, morphological and electrophysiological properties of two rat laryngeal muscles, the cricothyroid and posterior cricoarytenoid, have been measured. Both muscles act during respiration to maintain upper airway patency and an even distribution of air in the lungs. The cricothyroid and posterior cricoarytenoid are fast-twitch muscles, having contraction times of 3.4 and 7.2 ms respectively, high myosin ATPase activity, abundant sarcoplasmic reticulum (with average volumes of 9% and 15%, respectively, of the fibre volume) and T-system membrane (with average areas of 0.4 and 0.5 micron 2 micron -3 of fibre). The large areas of T-tubule membrane are reflected in the average specific membrane capacities of 6.5 muF cm-2 to 10.5 muF cm-2, which are high considering the small diameter of the fibres (20-30 micron). Of the two muscles, the posterior cricoarytenoid has the faster contraction time and the more abundant sarcoplasmic reticulum content. In addition, the posterior cricoarytenoid is less resistant to fatigue and demonstrates lower succinic dehydrogenase activity. The fatigability of this muscle, coupled with its general lack of functional reserve, suggest that its failure may contribute to upper airway obstruction during respiratory distress.
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PMID:The contractile properties, histochemistry, ultrastructure and electrophysiology of the cricothyroid and posterior cricoarytenoid muscles in the rat. 621 35

We assessed morphological, histochemical, and physiological characteristics of respiratory muscles of a non-human primate, Papio cynocephalus, from midgestation through adult life. Samples were taken of diaphragm muscles for histochemical analysis, electron microscopy, and assessment of contractile properties and fatigability. Histochemical analyses were also performed on samples of intercostal muscles. Initially, developing fibers are type IIc but differentiate into types I and IIa fibers by term. We observed no IIb fibers in respiratory muscles of premature baboons. Beginning late in gestation, muscle fibers grew rapidly. After term, IIb fibers were found, and fiber size ranked by increasing mean fiber area became types I, IIa, and IIb. After term, we rarely observed type IIc fibers. In electron micrographs we observed large numbers of interfibrillar mitochondria in all muscle fibers of premature baboons but not in all IIb fibers of adults. Histochemical observations were supported by contractile properties. Muscles of premature baboons had significantly longer contraction and relaxation times than adult muscles. Muscles from premature baboons were more resistant to fatigue than those of adult baboons. We conclude that the fibers of respiratory muscles are high in oxidative capacity and are resistant to fatigue during gestation. Fatigue of the respiratory muscle fibers secondary to low oxidative capacity is not a likely cause of respiratory distress in premature baboons.
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PMID:Development of histochemical and functional properties of baboon respiratory muscles. 683 51


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