Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The goal of this study was to clarify the subjective symptoms closely related to yusho by examining the relationship between the amount of PCB-contaminated rice oil ingested by patients and the subjective symptoms recorded on their questionnaires. The amount of PCB-contaminated rice oil consumed by the patients was obtained by interviewing the housewife in each yusho family. Individual consumption of the oil was estimated by taking into account age, sex and the number of meals at home. In 1970, 46 patients were available for analysis, and in 1971, 33 patients were available. Among 12 subjective symptoms studied, numbness of the limbs, coughing, expectoration, and the sensation of "elevated" teeth were considered to show a dose-response relationship, which suggests that these subjective symptoms are closely related to yusho. Consistent high rates of complaints of general fatigue and eye discharge were considered possibly to be connected with yusho, although no dose-response relationships have been determined. Other subjective symptoms, such as fever, headache, dizziness, abdominal pain, swelling in the joints, changes in menstruation, and loss of hair failed to show consistent dose-response relationships. It should be noted, however, that for these symptoms which failed to show dose-response relationships, it is impossible to deny a causal relationship.
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PMID:Relationship between the amount of rice oil ingested by patients with yusho and their subjective symptoms. 392 63

The aim of the present paper is to summarize the history of the Yusho incidence that occurred in the western part of Japan in 1968. A strange disease was reported in October 1968. This strange disease was characterized by acne-like eruptions, pigmentation of the skin, and eye discharge, and it was named Yusho (oil disease). Through systematic epidemiological studies based on observation of initial case series, and extensive efforts to clarify causal agents by the Study Group for Yusho, it was concluded that Yusho was caused by ingestion of rice oil contaminated with PCBs and PCDFs. As of now, more than 1,800 patients, have been registered as having Yusho and around 300 are deceased. Clinical observation showed that typical symptoms of Yusho have decreased, even general fatigue, headache and numbness of extremities have still been complained by patients. No effective treatment has been found so far. Careful and systematic observation for Yusho patients and medical care services should be continued for a further understanding of Yusho.
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PMID:Yusho in Japan. 1291 43