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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To determine whether images can stimulate brainstem reflexes directly, parotid salivation was measured bilaterally in 24 subjects when they imagined, and actually tasted, a sour taste on one side of the tongue. Salivation increased in both cheeks during unilateral gustatory stimulation; furthermore, the response was greater on the stimulated side than contralaterally, indicating that the gustatory reflex has a unilateral component. Subjects imagined the sour taste more clearly after actually experiencing it. However, salivation did not increase significantly during imagery trials, either before or after exposure to the sour taste; in fact, salivation to imagery decreased below baseline after exposure. These findings suggest that extraneous factors (e.g. the emotional connotations of images, anxiety, discomfort, repetitive measurement or fatigue) might sometimes inhibit specific reflex activity induced by images.
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PMID:Effect of imagining and actually tasting a sour taste on one side of the tongue. 771 18

EMG spectral shifts of anterior temporal and medial masseter muscles were evaluated. Mean power frequency (MPF) shift during fatigue and recovery of 46 healthy subjects and 46 patients with craniomandibular disorder were recorded at the beginning and the end of fatiguing clenching, then 3, 8, 13 and 18 min following the fatiguing clenching. The reference clenching force was 80% of each subject's maximal voluntary contraction (MVC). Recording was stopped when subjects felt pain or discomfort. Significance was found between the healthy group (N) and the diseases group (CMD) in the three following points: (i) the mean of MPF values of the masseter muscles at the end of fatiguing clenching; (ii) the recovery pattern of the temporal muscles; and (iii) MPF shift induced by fatiguing clenching. Our results therefore suggest that MPF reflects several aspects of craniomandibular disorders. Thus, measuring fatigue and recovery MPF could be useful in the screening of CMD.
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PMID:Mean power frequency shift during fatigue and recovery in patients with craniomandibular disorders. 772 48

The studies covered changes in functional state of 42 programmers working at VGA. All the examinees reported subjective evaluation of fatigue and variational pulsometry before and after the work at VGA, those who worked at the display for 3 hours underwent blood pressure and pulse rate measurements (with subsequent calculation of several hemodynamic parameters) before and after the work. The researchers applied Major Components Method to obtain some integral parameters. The obtained values described initial state of cardiovascular system and changes in autocorellation of some BCG intervals. The fatigue was proved to occur by the end of the second working hour, and by the end of the third hour the examines demonstrated unfavorable changes of functional state (depression of heart activities and increased blood pressure). Only those who worked over 4 hours reported discomfort, so functional disorders appear earlier, than individuals detect them.
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PMID:[Physiologic evaluation of permissible work timing at the video display]. 772 32

Diesel exhaust is a common air pollutant and work exposure has been reported to cause discomfort and affect lung function. The aim of this study was to develop an experimental setup which would allow investigation of acute effects on symptoms and lung function in humans exposed to diluted diesel exhaust. Diluted diesel exhaust was fed from an idling lorry through heated tubes into an exposure chamber. During evaluations of the setup we found the size and the shape of the exhaust particles to appear unchanged during the transport from the tail pipe to the exposure chamber. The composition of the diesel exhaust expressed as the ratios CO/NO, total hydrocarbons/NO, particles/NO, NO2/NO, and formaldehyde/NO were almost constant at different dilutions. The concentrations of NO2 and particles in the exposure chamber showed no obvious gradients. New steady state concentrations in the exposure chamber were obtained within 5-7 min. In a separate experiment eight healthy nonsmoking subjects were exposed to diluted exhaust at a median steady state concentration of 1.6 ppm NO2 for the duration of 1 h in the exposure chamber. All subjects experienced unpleasant smell, eye irritation, and nasal irritation. Throat irritation, headache, dizziness, nausea, tiredness, and coughing were experienced by some subjects. Lung function was not found to be affected during the exposure. The experimental setup was found to be appropriate for creating different predetermined steady state concentrations in the exposure chamber of diluted exhaust from a continuously idling vehicle. The acute symptoms reported by the subjects were relatively similar to what patients reported at different workplaces.
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PMID:Evaluation of an exposure setup for studying effects of diesel exhaust in humans. 780

The existing literature stresses the discomfort fatigue, and tension in the context of Neonatal Intensive Care Unit nursing work, which often lead to the so-called "burnt-out syndrome". It is not surprising that this might be prevalent in a department that it deals with children who are at the beginning of their lives but under constant threat of death. In order to overcome the above-mentioned difficulty starting from 1982 the Author arranged weekly meeting with the staff of Neonatal Intensive Care Unit of the Treviglio-Caravaggio Hospital (Bergamo). In this article, it is underlined that, in order for the work to develop, the staff needed to go through various mental states, which could be viewed as "typical phases", the most important resulting the "emotional atmosphere". Only after working through these phases the work group will discover his ability to observe the child as an integrated being with biological and emotional components and so will be able to perform his caring function.
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PMID:[Communication within a neonatal intensive therapy unit]. 781 88

In this double-blind, placebo-controlled, multicenter trial, we examined the combined effects of repeated exercise and intravenous enoxaparin (low-molecular-weight heparin) on treadmill exercise capacity and angiographic collateral growth and compared them with the effect of repeated exercise with placebo. Fifty-two patients with stable-effort angina were randomly assigned to receive one of two doses of enoxaparin (40 or 60 mg) or placebo. In each patient, 20 treadmill exercise sessions were performed with the pretreatment of enoxaparin or placebo for 2 to 3 weeks. Before and after treatment, coronary cineangiography was repeated to evaluate the changes in coronary and collateral circulation. Improvement of rate-pressure product (RPP) at the onset of angina was taken as an index of enhanced collateral flow reserve. Although the mean differences in the magnitude of increase in RPP were not significantly different between the 3 groups, a heterogeneous response was observed: 1620 beats/min.mm Hg in 40 mg (p = 0.12), 3060 beats/min.mm Hg in 60 mg (p = 0.02), and 1090 beats/min.mm Hg in placebo (p = 0.44). The end-points of the exercise test were changed from chest discomfort to leg fatigue or dyspnea in 10 (28%) of 36 enoxaparin-treated patients but in only 1 (6%) of 16 placebo patients (p = value not significant (NS)). Similarly, the extent of coronary and collateral circulation to the completely obstructed coronary artery was increased in 17 (47%) of 36 enoxaparin-treated patients but only in 4 (25%) of 16 placebo patients (p = NS).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Prospective, randomized, placebo-controlled, double-blind, multicenter study of exercise with enoxaparin pretreatment for stable-effort angina. 787 85

This article illustrates that the diagnostic evaluation as well as the management of the patient presenting with chronic fatigue can be done in an orderly manner. If a medical illness is the cause of the patient's fatigue, this is usually evident on initial presentation. A thorough history and complete physical examination, in conjunction with some screening laboratory tests, can rule out most medical causes of fatigue, and any remaining cases declare themselves over the next several visits. If a medical cause is not evident, a further "fishing expedition" is fruitless. Psychiatric illness, such as depression or generalized anxiety disorder, accounts for another significant proportion of cases of chronic fatigue. As with medical illness, psychiatric illness should be suspected based on history and is not a diagnosis of exclusion. Some patients presenting with chronic fatigue have a history and symptom pattern consistent with the diagnosis of CFS. The cause of this syndrome is controversial and is still unknown. The clinician, however, can offer the patient care in an environment that is respectful of their physical and psychological discomfort and can provide significant symptomatic improvement to the patient. Lastly, some patients with fatigue do not fit any diagnostic category, including CFS. As with many other common complaints, such as headaches or abdominal pain, although a diagnosis may not be given to the patient, the clinician can do a lot to reassure the patient and assist the patient in living with his or her symptoms. As Solberg eloquently wrote: "[E]valuation of the fatigued patient requires all of a physician's best attributes--a broad view of disease, psychosocial sensitivity, and a good ongoing relationship with the patient."
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PMID:The chronically fatigued patient. 787 93

In an open, multicenter trial, 329 patients (who attended gastroenterology practices or outpatient gastroenterology departments of hospitals) with a mean age of 47.3 years, received 5 mg of cisapride three times a day (TID) for at least 2 weeks for the treatment of persistent, recurring symptoms of functional dyspepsia. The patients' symptoms required investigation or were unresponsive to previous drug treatment. When necessary, the dose of cisapride was increased to 10 mg TID, in most patients after 1 week of treatment, and the duration of therapy was extended to 4 weeks. At the end of cisapride treatment, the most frequently reported symptoms of functional dyspepsia were significantly improved. At the onset of the trial, 72.3% of patients complained of a moderate-to-severe feeling of fullness; this decreased to 19.7% after 2 weeks of treatment and to 15.3% after 4 weeks. The symptoms of bloating, a feeling of heaviness in the stomach, and postprandial epigastric discomfort showed similar improvement. Overall, 43.6% of patients were symptom-free or almost symptom-free after 1 week of cisapride treatment, 69.6% after 2 weeks, and 71.5% after 4 weeks. Only 11% of patients needed the increased dose of cisapride. Six weeks after completion of the trial, 74 patients (22.5%) had recurrent symptoms of functional dyspepsia. Adverse experiences were noted in 74 patients (22.5%), most commonly loose stools (7.6% of all patients), fatigue (4.9%), and headaches (4.0%). In most cases, these adverse experiences were mild and transient in nature and led to premature discontinuation of treatment in 11 patients (3.3%).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Chronic functional dyspepsia: short- and medium-term outcome of a therapeutic trial with cisapride. 792 10

Prolonged work with visual display units (VDUs) may result in a wide range of subjective complaints of visual fatigue and somatic disorders. Accepted tests for measuring the physiological correlates of eye discomfort are lacking. In this study, we tested accommodation and convergence, which are most often linked experimentally with VDU work. The tests were carried out on 16 VDU and 13 control workers aged 24 to 43 years, before work at the beginning of the week (first examination) and again four days later at the end of the work day (second examination). The results in VDU workers showed that both accommodation and convergence range significantly decreased. In addition, those workers with powerful accommodative or convergence ranges at the initial examination had a higher decrease. We suggest that accommodation and convergence measurements can be used to evaluate visual fatigue objectively in VDU workers.
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PMID:Objective evaluation of visual fatigue in VDU workers. 794 62

The aim of the present study was to develop a theoretical understanding of elderly patients' experiences of pain and distress in intensive care, using a grounded theory approach. 18 patients, 7 women and 11 men, were interviewed and observed in an intensive care unit (ICU). Their average age was 76.5, varying from 70-85. A model was generated from data, according to which elderly patients' experiences of pain and distress in intensive care can be described as four interrelated aspects: a sensory, an intellectual, an emotional, and an existential dimension. 16 categories form the four dimensions. The categories, in turn, are grounded in a number of interview and observational data. The sensory dimension is formed by the categories physical pain, physical discomfort, fatigue, and breathing problems, and the intellectual dimension by the categories not knowing, difficulty in expressing oneself/not being understood and confused perception of reality. The categories in the emotional dimension are worry, fear, resignation, bitterness, anger/irritation and dependency. Finally, the existential dimension is formed by the categories despair, threat to life and death acceptance. The categories within the four dimensions may be separate, but often they interact and influence each other in various ways. The model is discussed in relation to existing models and definitions of pain, where the intellectual and existential dimensions in particular have not been emphasized in a similar way.
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PMID:Elderly patients' experiences of pain and distress in intensive care: a grounded theory study. 801 53


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