Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The publicity which has been given to Visual Display Terminals (VDTs) in recent years has been prompted by initial complaints from operators of visual and postural discomfort. The interest resulting from these complaints has led to much work being carried out on what appeared to be a potentially large problem. This work has precipitated recommendations and specifications from many quarters which in many cases are overcritical and rigid and do not take into account the great flexibility of the visual system and the need for mobility to maintain postural comfort. In this paper the VDT issue is considered with reference to: the known physiology of the visual and postural mechanisms; the psychological factors such as fatigue, boredom, stress and performance of operators; and the clinical aspects of ocular comfort.
 ...
PMID:The visual display terminal issue: a consideration of its physiological, psychological and clinical background. 662 39

Although the incidence of constrictive pericarditis is low, the increasing number of patients receiving chronic dialysis, aggressive radiotherapy, or cardiovascular surgery has caused an increase in the iatrogenic incidence. The most common symptoms are dyspnea, fatigue, weight gain, peripheral edema, and abdominal swelling and discomfort. They may be present for years before the diagnosis is made. Physical examination, x-ray studies, electrocardiography, echocardiography, cardiac catheterization, and angiography are all helpful in the differential diagnosis. Pericardiectomy, the only treatment, has a success rate of up to 90%. Untreated, the condition progresses to an incapacitating state.
 ...
PMID:Constrictive pericarditis: techniques for differential diagnosis. 675 May 84

Six male human subjects were placed in a situation of physiological conflict, fatigue vs. cold discomfort. Dressed in swim suits and shoes they walked at 3 km X h-1 on a treadmill placed in a climatic chamber. The slope of the treadmill was varied from 0 to 24% and the ambient temperature (Ta) from 25 to 5 degrees C. The subjects could choose Ta when slope was imposed or the converse. They rated pleasure and displeasure of Ta and exercise. Deep body temperature and heart rate were monitored. The results show that the subjects adjusted their behavior to maintain approximatively steady deep body temperature and to limit heart rate below 120 beats X min-1. The physiological compromise was thus correlated to the drive for maximal pleasure-minimal displeasure in the two sensory dimensions fatigue and discomfort.
 ...
PMID:Physiological conflict in humans: fatigue vs. cold discomfort. 684 71

Workers interacting with video display units for periods in excess of two hours per day report significantly increased visual discomfort, fatigue and inefficiencies, as compared with workers performing similar tasks, but without the video viewing component. Difficulties in focusing and the appearance of myopia are among the problems being described. With a view to preventing or minimizing such problems, principles and procedures are presented providing for (a) modification of physical features of the video workstation and (b) improvement in the visual performances of the individual video unit operator.
 ...
PMID:Prevention: lessons from video display installations. 685 57

More than 1200 patients who received pindolol for the treatment of hypertension, angina pectoris, and various arrhythmias in studies conducted in the United States were included in the New Drug Application submitted to the FDA. Nearly 1000 of these patients received pindolol as monotherapy. The side effects reported were generally transient and of mild or moderate severity. The most frequently reported side effects seen after pindolol administration, compared to those seen after placebo, were in decreasing order of incidence: headache, dizziness, insomnia, muscle pain, fatigue, weakness, nervousness, joint pain, edema, nausea, and muscle cramps. Other side effects that occurred more frequently with pindolol than with placebo but at a rather low incidence induced weight gain, bizarre dreams, visual disturbances, lethargy, and diarrhea. Nasal congestion, throat discomfort, nocturia, impotence, pruritus, anxiety, hypotension, bradycardia, and heart failure occurred only rarely. Of the 323 patients who received pindolol alone for the treatment of mild to moderate hypertension, only 20 (6.2%) were withdrawn from the study because of side effects. Overall, 3.4% of the patients treated with pindolol were withdrawn because of side effects, most of which involved the central nervous system, that is, insomnia, anxiety, dizziness, and headache. However, a few patients manifested some edema and weight gain while receiving pindolol alone. Review of the side effects data did not reveal a tendency for the incidence of side effects to be dose related. One placebo-controlled, double-blind study designed to evaluate the fixed dosages of 15, 30, and 60 mg in the treatment of mild to moderate hypertension suggested that only the incidences of insomnia and nervousness increased with increasing doses. However, these side effects were generally transient and of mild or moderate severity. The evidence indicates that pindolol has an acceptable safety profile and that any side effects that appear are generally well tolerated and disappear with continued treatment.
 ...
PMID:Adverse reactions to pindolol administration. 704 82

Studies on prodromata of myocardial infarction (MI) and sudden cardiac death suggest that psychological experiences like 'general discomfort', 'fatigue/weakness', and 'emotional changes' are as frequently reported as 'chest pain'. A psychological survey - the 'Maastricht Questionnaire' (MQ) - was constructed to measure those prodromata. In several studies it was found that the MQ was positively associated with imminent MI, with MI, with the Type A coronary-prone behavior pattern, and with reported stressful life changes. These associations do not appear to be confounded by somatic risk factors, thus implying to measure an independent psychologic constellation.
 ...
PMID:Factors contributing to the development of vital exhaustion and depression in male myocardial infarction patients. 718 61

Follow-up results of two series of patients, one group of 50 vagotomy-antrectomies and another of 100 vagotomy-pyloroplastie, were compared after an average of 2,5, and 10 years. Nutrition, the capacity for work, and resistance to fatigue were better after pyloroplasty. After antrectomy there is a progressive decrease in nutrition, body weight varying by 2.730 kg. Digestive discomfort occurs after pyloroplasty, however, and does not improve with time : about half of the patients complain of post-prandial heaviness. Anastomotic ulcers are observed in 6 p. cent of patients after pyloroplasty, and 4 p. cent after antrectomy. Relapses after pytoroplasty occur at an early stage and are mainly due to failure of the vagotomy ; in this series their level remained stable. Phytobezoar is an elective complication of pyloroplasty and was noted in 4 p. cent of cases. The need for repeat operations (4 p. cent of cases) was identical in both groups.
 ...
PMID:[Duodenal ulcers. Vagotomy-antrectomy or vagotomy-pyloroplasty. Comparison after ten years (author's transl)]. 721 36

In a prospective study, 68 hospitalized patients were diagnosed as having giant cell arteritis. Temporal artery biopsy was performed in all patients and showed histologic evidence of arteritis in 42 (62%). Twenty-six patients had a negative biopsy but met the clinical criteria for the diagnosis. Four different clinical pictures were recognized. Thirteen patients (19%) had symptoms of localized temporal arteritis without muscular discomfort. The polymyalgia rheumatica syndrome without signs of localized arteritis was seen in 33 patients (49%). Seventeen (25%) had symptoms of both polymyalgia rheumatica and temporal arteritis. Five patients (7%) had general symptoms only, such as fever, anorexia, and fatigue, without muscular or arteritic symptoms.
 ...
PMID:The clinical pictures of giant cell arteritis. Temporal arteritis, polymyalgia rheumatica, and fever of unknown origin. 735 May 59

A 20-year-old female was brought to our emergency unit with generalized erythema and discomfort induced by running after having eaten wheat bread. The laboratory examinations, including eosinophils, total IgE, RAST score to wheat, heat challenge test and methacholine inhalation test were within normal limits. No anaphylactoid responses occurred after provocation tests of wheat bread intake or exercise alone. However, on provocation exercise test after eating pancakes, she developed hypotension, generalized itching and urticaria associated with an elevation of plasma histamine levels. These findings suggested wheat-dependent exercise-induced anaphylaxis. This was completely prevented by daily administration of terfenadine 120 mg p.o. without side effects such as fatigue or drowsiness.
 ...
PMID:Successful prophylaxis of wheat-dependent exercise-induced anaphylaxis with terfenadine. 749 78

Influences of physical and psychosocial work environments and personal factors on sick building syndrome symptoms were investigated in 167 clerical workers before and one year after moving from a naturally ventilated building to an artificially ventilated building. Female gender and work on visual display units were independently associated with most symptoms in the baseline survey and with the incident (new) symptoms in the follow-up survey. After changing buildings, the prevalences of eye, skin and fatigue symptoms increased significantly. Cold and discomfort due to stuffiness were independently associated with incident eye and respiratory symptoms. Reported domestic workloads were greater for women, but did not account for any gender differences in symptom prevalence.
 ...
PMID:Sick building symptoms in office workers: a follow-up study before and one year after changing buildings. 770 66


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>