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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a randomized, parallel, double-blind study, lisinopril (n = 412) reduced systolic and diastolic blood pressure more than nifedipine did (n = 416) after ten weeks treatment in patients (40-70 years) with mild to moderate essential hypertension. Lisinopril was tolerated better than nifedipine, with fewer withdrawals. Adverse experiences reported after a general question on discomfort were significantly lower for lisinopril than for nifedipine. Questions referring specifically to symptoms revealed higher frequency of coughing with lisinopril, while flushing, edema, palpitations, dizziness, tiredness and rash were reported more frequently with nifedipine. Quality of life was similarly assessed by both patients and spouses. No significant differences in well-being during treatment were found for either drug, except in the case of the highest dose level of nifedipine, which caused a deterioration of well-being.
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PMID:[Treatment with lisinopril or nifedipine in essential hypertension. A Norwegian multicenter study of the effect, tolerance and quality of life of 828 patients]. 133 84

Epidural administration of hydromorphone was evaluated using a patient-controlled analgesia (PCA) delivery system in 170 healthy women undergoing elective cesarean delivery with epidural bupivacaine who were randomly assigned to one of four epidural PCA treatment groups: group I, hydromorphone alone by bolus administration; group II, hydromorphone, with a continuous (basal) infusion; group III, hydromorphone in combination with 0.08% bupivacaine by bolus administration; or group IV, hydromorphone and bupivacaine, with a concurrent infusion of both drugs. Patients in group I required significantly less opioid medication (2.1 +/- 1.1 mg [mean +/- SD]) during the first 24 h than patients in group II (3.3 +/- 1.3 mg). Similarly, patients in group III self-administered significantly less hydromorphone (2.0 +/- 1.0 mg) and bupivacaine (23.3 +/- 11.4 mg) during the first 24 h of PCA therapy, compared with patients in group IV (hydromorphone [2.7 +/- 1.1 mg] and bupivacaine [31.5 +/- 11.6 mg]). The concomitant use of a local anesthetic or basal opioid infusion with hydromorphone via epidural PCA did not decrease the number of PCA demands or delivered doses. In addition, patients in all four groups had similar pain, sedation, discomfort, fatigue, and anxiety scores. The frequency of awakening at night to self-administer analgesic medication was not decreased when a basal infusion was used.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Epidural patient-controlled analgesia: influence of bupivacaine and hydromorphone basal infusion on pain control after cesarean delivery. 138 97

Internal noise related mainly to the activities and overcrowding of schools is the main source of teachers' discomfort. It causes negative feelings and generates various hindrances at work in 80.2% of women and 67% of men. for a substantial part of the teachers' milieu (42.1% of women and 32.3% of men), noise is the dominant element among the whole complex of adverse professional factors. In schools with a higher noise level, the number of teachers assessing negatively the acoustic climate of schools increases, and the intensity of discomfort is enhanced. This is associated with awareness of excessive vocal effort, as well as with intensification of discomfort symptoms and of negative emotions. The group of teachers working under more adverse acoustic conditions is characterized by higher incidence of irritation states, deconcentration of attention, sleepiness, tiredness, depression and headaches. Moreover, there are symptoms on the part of the cardio-vascular, upper respiratory and digestive system, as well as signs of neurosis. Some of these health problems are intensified in smokers.
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PMID:[Evaluation of school noise by teachers and assessment of its effect on health and general feeling]. 147 Aug 67

The study examined the work stresses of 107 women who were engaged in sewing machine operation in small garment manufacturing units. Of the three types of sewing machines (motor-operated, full and half shuttle foot-operated), 74% of the machines were foot-operated, where throttle action of the lower limb is required to move the shuttle of the machine. The motor-operated machines were faster than the foot-operated machines. The short cycle sewing work involves repetitive action of hand and feet. The women had to maintain a constant seated position on a stool without backrest and the body inclined forward. Long-term sewing work had a cumulative load on the musculo-skeletal structures, including the vertebral column and reflected in the form of high prevalence of discomfort and pain in different body parts. About 68% of the women complained of back pain, among whom 35% reported a persistent low back pain. Common sewing work accident is piercing of the needle through the fingers, particularly the right forefingers. Unsatisfactory man-machine incompatibility, work posture and fatigue, improper coordination of eye, leg and hand are the major problems of the operators. The design mis-match of the work place may be significantly improved by taking women's anthropometric dimensions in modifying the workplace, i.e. the seat surface, seat height, work height, backrest, etc.
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PMID:Work stress of women in sewing machine operation. 149 Nov 71

The negative effects of noise on sleep and behaviour have been related to three mechanisms: a physiological arousal (above a certain threshold of noise), an aversive reaction and an interference with non auditive neurophysiological and mental processes. The perturbation of verbal communication and the effects of sleep are the directly observable consequences. The negative effects of noise above a certain threshold on sleep have been demonstrated both in experimental conditions and in real life. They concern length, EEG pattern, and subjective quality and produce an increase of irritability and tiredness. There is no habituation. In all populations studied, strong discomfort is expressed by 50% of the subjects living in an area with an Ldn of 75 dB in the case of air traffic noise, the same results being obtained with ground traffic for a 5-15 dB higher level. Objective expressions of discomfort: use of aural protections, closing the windows, staying indoor, changing residence, increase linearly with the intensity of noise. Noise influences the incidence of stress-related disorders: hypertension, related cardio-vascular diseases, psychosomatic and psychological disorders. It has been shown by the use of different techniques (epidemiological studies based on the frequency of medical contacts, on the diagnoses made by general practitioners, on the use of specific drugs, and on the examination of the whole population) that the prevalence increases in relation with the level of noise in the vicinity of airports.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Noise, sleep and behavior]. 150 64

An intervention study of cashiers at a large grocery store was begun in response to employee symptoms of musculoskeletal discomfort, primarily shoulder, neck, and upper back pain, after introduction of a new express checkstand. The grocery company then instituted workplace changes directed at reducing stressful postures and the discomfort in the anatomical sites of primary concern. These changes were placement of a physical barrier to reduce trunk flexion from overreaching, installation of an adjustable keyboard to reduce static shoulder stress, and education of employees about good workplace practices to reduce musculoskeletal stress and fatigue. There was a statistically significant reduction in neck, upper back, or shoulder discomfort but not arm, forearm, or wrist discomfort. There was also a significant reduction in employee use of medication and days to recovery from discomfort but not in overall number of employees with symptoms or in hours able to operate the checkstand without discomfort. We found that ergonomic interventions, directed to the anatomical site of greatest employee concern, are likely to be effective, that employees were a good source of information on the ergonomic problems and solutions in their workplace, but that the overall approach must be iterative to achieve the maximum effect.
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PMID:Musculoskeletal discomfort in grocery express checkstand workers. An ergonomic intervention study. 150 40

The heading craniomandibular disorders covers a wide range of abnormal and pathologic conditions accompanied by orofacial pain and impaired mandibular function, the masticatory muscles and the temporomandibular joints being the structures most frequently involved. Prevalences of severe craniomandibular disorders accompanied by headache and facial pain urgently in need of treatment are 1-2% in children, about 5% in adolescents, and 5-15% in adults, with higher values in women than in men. With respect to physiology and ergonomics, masticatory muscles are comparable to other human skeletal muscles, e.g. of shoulder, neck and lower back. Therefore these muscles share pathogenesis, symptoms and signs of muscular disorders caused by prolonged, low-level static contractions or intermittent isometric contractions at higher levels. Since the same elements of performance in the masticatory muscles are influenced by occlusal factors, they link the development of muscular fatigue, discomfort and pain to the dental occlusion. Furthermore, changes of the occlusal surfaces, e.g. due to dental treatment, may influence the performance of the masticatory muscles, and consequently interfere with local muscular function.
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PMID:Craniomandibular disorders and masticatory muscle function. 155 1

Two hundred women in the third trimester of a first pregnancy were interviewed, and 50 of them were interviewed again at 4 months post partum. They were asked whether they experienced greater current difficulty in performing 46 common tasks than they did before pregnancy and were asked to grade their responses. Additional information concerning specific factors affecting each activity, such as discomfort and fatigue, was obtained, together with data concerning socioeconomic status and stress perception. The data were analysed to identify the activities whose performance was most and least affected by pregnancy, indicating that the pregnant condition affects perceived difficulty of performance in many activities. Although some activities are not amenable to ergonomic intervention, the study highlighted some in which equipment design and selection could improve the match between a task and the pregnant.
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PMID:Performance of physical tasks in pregnancy. 157 39

We describe the surgical management and followup of 11 patients with local recurrence of renal cell carcinoma in the renal fossa, 10 of whom demonstrated no evidence of distant metastatic disease at the time of recurrence. Average interval to recurrence was 31 months from nephrectomy, with the majority of patients presenting with symptoms of weight loss, fatigue and lumbar discomfort. A total of 13 resections of recurrent carcinoma was performed with 3 immediate postoperative complications, including a retroperitoneal abscess, jejunal necrosis requiring resection and a duodenal obstruction requiring duodenojejunostomy. There were 2 postoperative deaths, 2 patients died of disseminated disease at 8 and 22 months, and 3 died of causes unrelated to cancer recurrence at 4 months, 6 months and 10 years. Four patients were without disease at a followup of 35, 46, 48 and 211 months. We include in this review a report on 1 patient who maintains a disease-free survival of 17 years after resection of a recurrent spindle cell carcinoma. We conclude that an aggressive surgical approach to recurrent renal cell carcinoma within the renal fossa can produce long-term disease-free survival and is justified when compared to the results reported for chemotherapy.
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PMID:Experience with fossa recurrence of renal cell carcinoma. 159 72

Although there is an abundant literature on the health effects of occupational heat exposure, very few authors have addressed the question of the effects of heat stress on women workers. Knowledge about the effects of work in hot environments is mainly derived from the study of "heavy" muscular activity and current heat exposure standards are based on an energy criterion according to metabolic load. Metabolic load does not reflect cardiac strain associated with sedentary, repetitive work, involving static effort. The research presented here was conducted in an industrial laundry with 11 women mangle operators exposed to moderate heat stress during the summer months and whose work activity is classified as light on the basis of energy expenditure. Physiological and symptomatological responses, work activity and ambient temperature were assessed over 3 complete work days in summer and in winter. Recorded and perceived temperature, discomfort, feelings of fatigue and symptoms of thermal stress were significantly higher in summer than in winter. Symptoms of drowsiness and musculo-skeletal aches were reported equally in both seasons. Heart rate was high in both seasons, as were calculated indices of cardiac strain. Recommended limits for cardiac strain were surpassed significantly more often in summer than in winter. It is suggested that threshold levels should be redefined to include the prevention of cardiac strain resulting from cumulative effects of heat stress and sedentary, repetitive activity, typical of many women's job with low energy requirement.
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PMID:Heat exposure standards and women's work: equitable or debatable? 161 88


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