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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An inventory of 69 somatic discomforts was used to identify those discomforts most likely to be concurrent with a clinically severe depression in a sample of 223 recently hospitalized women. The inventory provided scores for each of 15 classes of discomfort. The classes of discomfort with the highest average score for the depressed sample at admission also yielded significantly lower scores for a nonpatient control sample (P less than .05). The four classes of discomfort most pertinent to depression were designated autonomic, wakefulness, dry mouth, and fatigue. The items of discomfort contributing to these classes showed a statistically significant diminution in severity during treatment (P less than .05).
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PMID:Somatic discomforts among depressed women. 10 3

Prevalence rates of various side effects were studied comparatively among 3 oral contraceptive preparations containing 50 mcg of the estrogen component. Norinyl 1/50, Ovral, and Norlestrin 1 were each randomly assigned to groups of 160 healthy women who had consented to participate in the study designed to quantitate probabilities of experiencing specific side effects and of their continuing into the subsequent cycles. Acne, breast discomfort, nausea, abdominal bloating, headache, fatigue, depression, irritability, vaginal discharge, and breakthrough bleeding were the specific side effects studied; only breakthrough bleedings showed a statistical difference in prevalence. The rate of breakthrough bleeding associated with Ovral use in the 1st 3 cycles (16.6%) was significantly (P .05) lower than that associated with using either Norinyl or Norlestrin (46% and 51.7%, respectively). Norelestrin, aside from breakthrough bleeding, was reported as generally freer of side effects than the other 2 preparations. The probabilities of side effects being experienced in the 2nd or 3rd cycle after the effect(s) was experienced in the 1st cycle showed that overall, for all 3 combination pills, the probabilities significantly decreased from the 2nd to the 3rd cycle (P .05). Also examined was the probability that a side effect would occur in the 2nd or 3rd cycle if the user had not experienced such an effect in the 1st cycle. In each instance, the probabilities are significantly lower (P .05) than the corresponding probabilities where the symptom had been experienced in a previous cycle. These data support the contention that side effects experienced on inititation of oral contraceptives should not prohibit its continuation because the majority of symptoms will disappear as the patient becomes accustomed to the hormonal preparation.
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PMID:The probability of side effects with ovral, norinyl 1/50 and norlestrin. 16 Aug 60

Six women, aged 24 to 53, presented with symptoms of diffuse aching, morning stiffness, and fatigue, but demonstrated no objective abnormalities on joint examination or in laboratory studies. Each was found to have idiopathic edema, a disorder of fluid retention probably related to an abnormality of capillary permeability in which transudation of fluid into the subcutaneous tissues of dependent parts may result in swelling and discomfort. The rheumatic symptoms improved when therapeutic measures were directed against the accumulation of edema fluid. This syndrome may account for a minority of cases of nonarticular rheumatism in women.
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PMID:Idiopathic edema as a cause of nonarticular rheumatism. 31 41

Ozone (O3) at near ambient smog alert levels has previously been shown to cause alterations in pulmonary function and exercise response in humans. The present study was designed to investigate the effects of O3 administered during graded bicycle exercise to volitional fatigue on work performance and maximal oxygen uptake (VO2max). Nine subjects performed three tests each while breathing either 0.00, 0.15, or 0.30 ppm O3. Forced vital capacity, residual volume, maximal midexpiratory flow rate, and forced expiratory volume in 1 s were assessed before, immediately after, and 4 h after exercise. O3 exposure resulted in no significant effect on maximal work rate, anaerobic threshold, or any pulmonary function parameter. However, maximal expired minute ventilation was decreased (P less than 0.05) in a dose dependent fashion. Thus, exercise ventilation during maximal work was a more sensitive indicator of the effects of O2 exposure than were standard pulmonary function tests. Although subjective symptoms of discomfort were reported more frequently with increased O2 level, it was concluded that exposure of healthy young men to as much as 0.30 ppm O2 for no more than 30 min of progressively incremented exercise to volitional fatigue, is insufficient to cause a significant decrease in work capacity or V02 max.
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PMID:Effects of oxone inhalation on work performance and VO2 max. 42 46

Pulmonary emboli seldom recur, and when recurrence does occur it is not associated with permanent sequelae unless there is progressive pulmonary arterial hypertension. Five patients with clinical and perfusion lung scan evidence of recurrent pulmonary embolism presented with abnormal cardiac rhythms without evidence of progressive pulmonary hypertension. Twenty-four-hour ambulatory electrocardiographic monitoring was valuable in diagnosis and in assessing the effectiveness of treatment. Although palpitation was the main complaint, other symptoms included tiredness, mild exertional dyspnoea, and chest discomfort unrelated to effort. Symptomatic improvement coincided with objective evidence of improvement from repeat lung scans and 24-hour ECG records. Antiarrhythmic agents controlled the arrhythmias but were subsequently withdrawn without the return of symptoms. Four of the five patients continued to take anticoagulants for two years. We believe that these five patients represent a group of patients with recurrent pulmonary emboli and a recognisable clinical picture dominated by arrhythmias unrelated to progressive pulmonary arterial hypertension. Long-term anticoagulant treatment was associated with clinical improvement.
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PMID:Recurrent pulmonary thromboembolism presenting with cardiac arrhythmias. 48 14

Dyspnea is the medical term for the patient's or subject's complaint of shortness of breath. It encompasses the respiratory discomfort experienced in many different diease states as well as the shortness of breath felt by a normal subject during or after strenuous exercise. Several parameters which have been shown to correlate with the onset or severity of dyspnea are described, including reduced vital capacity, the ratio of minute ventilation to vital capacity, reduced breathing reserve, the work of breathing, and the oxygen cost of breathing. Attempts at quantitation of dyspnea have usually consisted of measuring physiological parameters associated with the sensation, such as the "dyspneic index". The direct measurement of respiratory sensations using modern psycho-physical methods is at an early stage of development. Since the observation that the existence of dyspnea is often unrelated to any disturbance of arterial blood gas composition, it has been generally held that the mechanism of dyspnea is primarily neurophysiological. The neural pathways may conceptually be divided into those which transmit the "dyspnea message" from the respiratory apparatus to integrating centers in the brain, and those concerned with subsequently bringing the sensation to the level of consciousness. It seems likely that there is no single sensing mechanism and neural pathway which will be able to explain dyspnea in the diverse populations of patients and subjects who experience unpleasant respiratory sensations. Three theories concerning mechanisms of dyspnea are briefly described: "length-tension inappropriateness", vagal afferent activity especially from the J-receptors, and the recent concept of diaphragmatic fatigue. Some specific characteristics of the shortness of breath experienced in certain disease states are described, including chronic bronchitis and emphysema, bronchial asthma, pulmonary fibrosis and congestive heart disease.
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PMID:Dyspnea. 50 81

Ten subjects were exposed to high-G on the human centrifuge using seatback angles of 13 degrees, 30 degrees, 45 degrees, 60 degrees, and 75 degrees from the vertical, and body configurations of the lower portion of the body with pelvis and legs elevated, pelvis, elevated, and pelvis elevated with knees on chest (fetal position). Tolerance was measured by peripheral light loss. Mental status, respirations, core and ambient temperatures, and ECG were monitored. Daily physio-chemical data included: creatinine, bilirubin, phosphorus, alkaline phosphatase, uric acid, cholesterol, total protein, albumin, BUN, glucose, LDH cardiac isoenzyme No. 5, SGOT, SGPT, CPK, CBC, and urinalysis. Tiredness, pressure on the chest, and general discomfort in the fetal position were reported. Physical examination demonstrated petechiae. Heart rate, respiratory rate, and temperature increased post-session. There was a significant rise in values for albumin, chloride ion, creatinine, calcium, LDH, BUN, and immature white cells; and a decrease in values for phosphorus, SGOT, SGPT, protein, uric acid CO2, globulin, hematocrit, monocytes, and eosinophils.
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PMID:Psycho-physiological assessment of acceleration-induced changes in various seat configurations. 86 40

The Papago people in the Tohono village have a repertoire of culturally stylized patterns of behavior to help them maintain their health. The use of foods and ceremonies for preventing illness and maintaning health are emphasized in the styles of the people as well as the concept of taking care of self and others. Comfort and discomfort, fatigue, aches, thirst, hunger, and sadness are daily experiences of the people. Laughter, crying, "taking care of self and others", walking slowly, eating beans and tortillas, maintaining calm thoughts, and so on, are all culturally defined patterns for coping with alterations in feeling. When professional healers are needed, they will be consulted according to how helpful people perceive these healers to be by their sensitive attitudes and actions. The medicine man, nurses, medicine ladies, the ladies-who-pray, physicians, and St. Francis are perceived to be members of the health care team for the Papago people. The meaningful patterning of culturally defined behavior must be understood within the context of the Papago cultural system. As illustrated by the Tohono, "taking care of self and others" is highly valued, but it is only meaningful as we understand the rules of the Papago society, particularly the religious and kinship systems. These systems tell us that family members are important in taking care of themselves and others. Thus, the description in this paper of culturally patterned health practices with their rituals, ceremonies, and ways to help maintain health and heal the sick help the reader to understand the importance of health and healing behaviors within a designated cultural context. In this study, it is the Papago community and their specialty life ways of maintaining health and preventing illnesses.
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PMID:Observations of a health and healing system in a Papago community. 101 85

Nineteen patients, each hospitalized with a major depressive episode, were deprived of sleep for one night. Ten patients responded with clear improvement in depressive symptoms; the substantial clinical change was transient, usually lasting one day. Those who responded had significantly higher initial depression ratings (P less than .01) and tended to be older than nonresponders who experienced mild increases in irritability, fatigue, and discomfort following sleep deprivation. Amine metabolites, 5-hydroxyindoleacetic acid (5HIAA), and homovanillic acid (HVA) were not substantially affected by sleep deprivation, although there was a significant interaction of clinical response and direction of 3-methoxy-4-hydroxyphenylglycol (MHPG) change. Sleep deprivation thus produces acute, but only transient improvement in a selected group of severely depressed patients; it appears to be an important tool in the study of the affective disorders.
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PMID:Effects of sleep deprivation on mood and central amine metabolism in depressed patients. 126 78

The female climacteric is attributed to physiological ovarian failure with the consequent decrease in the secretions of oestrogen, progestones and androgens. Numerous metabolic, psychological and physical changes have been associated with this event. Oral discomfort, including the burning mouth syndrome and the dry mouth syndrome, has been described as a menopausal symptom. However, the relationship between the hormonal changes related to climacteric and the onset of oral discomfort is still controversial. The purpose of the present study was to evaluate the prevalence of oral symptoms, with particular regard to burning sensation, xerostomia, altered taste and recurrent oral ulcerations. The relationship between oral and climacteric symptoms and psychological status of the patients was also evaluated. A questionnaire was administered to 136 women (mean age: 51.2 years, range 40-62) being consecutively referred to the University Hospital Menopause Clinic from October 1991 to March 1992. The questionnaire included informations regarding menopausal state, oral symptoms, drug assumption, wearing of partial or total dentures, parafunctions (lip and cheek biting, bruxism, tongue thrusting). Climacteric symptoms including flushes/sweats, palpitations, headache, arthralgia/myalgia, vaginal dryness, decreased concentration, tiredness, decreased libido, insomnia, vertigo were evaluated. Visual analogue scale (VAS) was used where appropriate. Information regarding the alteration of the psychological status was collected by means of the Hospital Anxiety and Depression Scale Statistical analysis was performed by chi 2 test or Fisher's Exact Probability Test and Mann-Whitney U-test. The level of significance accepted was 5%. The subjects in this study were divided into two groups on the basis of their answers to the questionnaire: group I (no. 39), premenopausal women; group II (no. 97), menopausal women.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Oral symptoms in the climacteric. A prevalence study]. 129 73


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