Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Of 21 sudden deaths in sportsmen, 18 were thought to be caused by heart attacks either during or after sport. There was firm evidence of ischaemic heart-disease in 9, strongly suggestive evidence in 7, but in 2 there was only suggestive clinical evidence. As a group, these subjects were characterised by (1) a mean age above thirty (above twenty-five for rugby players); (2) a family history of early heart-attacks; and (3) antecedent symptoms of chest pain or pressure in 9, fatigue or blackout in 4, and minor complaints in 2. Most were known to their medical practitioners. Psychological factors were thought to be important in 8. Doctors, players and referees should be aware that severe sporting exertion as in rugby football involves a risk which for most players is relatively minor, but in the minority predisposed to heart-attacks by family history, smoking, or age (as in referees) the risk is more serious. To reduce hazard of sudden death in exercise, players and referees should be warned against smoking and informed of the serious implications of the development of chest pain, pressure, or undue tiredness before, during, or after sport.
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PMID:Sudden death and sport. 4

A multivariate analysis of the data was conducted to evaluate the effects of age, gender, and performance status on symptom profile. A comprehensive prospective analysis of symptoms was conducted in 1,000 patients on initial referral to the Palliative Medicine Program of the Cleveland Clinic. The median number of symptoms per patient was 11 (range 1-27). The ten most prevalent symptoms were pain, easy fatigue, weakness, anorexia, lack of energy, dry mouth, constipation, early satiety, dyspnea, and greater than 10% weight loss. The prevalence of these 10 symptoms ranged from 50% to 84%. Younger age was associated with 11 symptoms: blackout, vomiting, pain, nausea, headache, sedation, bloating, sleep problems, anxiety, depression, and constipation. Gender was associated with 8 symptoms. Males had more dysphagia, hoarseness, >10% weight loss and sleep problems; females, more early satiety, nausea, vomiting, and anxiety. Performance status was associated with 14 symptoms. Advanced cancer patients are polysymptomatic. Ten symptoms are highly prevalent. Symptom prevalence for 24 individual symptoms differs with age, or gender, or performance status.
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PMID:The symptoms of advanced cancer: relationship to age, gender, and performance status in 1,000 patients. 1078 56

Two studies were conducted to evaluate physiological responses and possible tolerance to high sustained +Gz forces at the USAF School of Aerospace Medicine, using the 20-ft (6.10 m) radius Human Centrifuge. In the first study (A), 14 human volunteer subjects--fully protected with an anti-G suit and performing the M-1 or L-1 straining maneuver--were exposed to +Gz forces. These forces began at +6.5 Gz, and increased weekly in 0.5 G increments to +9.0 Gz, for a duration of 45 sec at each level. Physiological performance was based mostly on the subjects' ability to maintain clear vision during the 45 sec exposure. Of the 14 subjects, 9 were able to maintain vision and remain at the +9 Gz level for 45 sec. In the second study (B), 12 human volunteer subjects--also protected with anti-G suits and using the straining maneuvers--were exposed to levels of +1, 3, 6, and 8 Gz, for 60 sec at each level. Extensive physiologic parameters were recorded in order to detect objective criteria which could be used as determinants for a medical tolerance endpoint to the particular level of +Gz stress. In both studies, the reasons for stopping the runs at levels exceeding +7.5 Gz included: fatigue, cardiac arrhythmias, blackout, and one occurrence of ventricular tachycardia. Other physiological responses to the sustained +Gz stress (such as heart rate, arterial blood pressure, central venous blood pressure, arterial oxygen saturation, gastric pressure, and ankle venous pressure) did not furnish specific information that could be used as "physiological tolerance limit" criteria.
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PMID:Physiological effect of high, sustained +Gz forces on man. 1200 3

Efficient usage of finite energy resources is a core approach for preventing major blackouts caused by a severe lack of energy. Smart windows, which modulate thermal energy transferred from the incident sunlight, have attracted tremendous interest as an alternative technology for resolving the fast-approaching energy crisis by suppressing unnecessary energy usage such as air conditioning or heating inside buildings. Here, we demonstrate a set of materials and design concepts for doubly responsive smart windows, which efficiently reduce the consumption of our limited energy reserves. The proposed smart windows are based on the concept of combining the lower critical solution temperature of thermoresponsive polymer hydrogels and the electrical actuation of graphene-based flexible heaters; this combination serves to actively control the passive-type moving thermoresponsive smart window. The proposed smart windows exhibit a highly tunable transparency of above 90%, which corresponds to an almost instantaneous change from high transmission of the incident light to the complete blockage of its penetration under thermal or electrical stimulation. In particular, when the windows of a mockup house are replaced with the developed flexible smart windows, the increment rate of the indoor temperature under white light irradiation reduces drastically. This type of active light control system is expected to create a new opportunity for achieving cost savings on heating, cooling, and lighting through management of light energy transmitted into the interior of a house.
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PMID:Actively Operable Thermoresponsive Smart Windows for Reducing Energy Consumption. 3261 50