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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The perception of jaw position, measured as the ability to produce a predetermined mandibular posture repetitively, was recorded under different experimental conditions. A control group of asymptomatic subjects was tested before and after anesthesia of the TMJs and after fatigue of the masticatory muscles. Groups of patients with craniomandibular disorders of arthrogenic or myogenic origin were also tested. None of the experimental variables affected position perception, and the patient groups did not differ from each other or the normal group in perception of jaw position. The possible clinical value of such recordings in differential diagnosis is therefore open to question.
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PMID:Perception of jaw position during different conditions. 263 94

This brief review presents an update of studies on postoperative fatigue and convalescence and the way in which they are affected by anesthetic technique. Development of postoperative fatigue is related to the degree of surgical trauma, but not to general anesthesia, and it cannot be predicted from age, sex, duration of surgery, or preoperative assessment of various nutritional parameters. Postoperative fatigue correlates with deterioration in nutritional status and impaired adaptability of heart rate to orthostatic stress and bicycle exercise. Decreases in muscle performance and endurance are associated with postoperative fatigue, but psychological factors such as preoperative degree of anxiety do not appear to be important factors. Pain relief with regional anesthetics does not improve postoperative fatigue after abdominal surgery; however, no studies are available that evaluate the effects of regional analgesia with concomitant inhibition of the stress response. Controlled studies suggest that the use of regional anesthesia with local anesthetics reduces duration of hospitalization and time to ambulation. Further studies are needed to define the relative roles of immobilization, impaired nutritional intake, and surgical stress response in the pathogenesis of postoperative fatigue.
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PMID:Anesthetic technique and surgical convalescence. 265 69

This review describes the movements of the parts of the chest wall (rib cage and abdomen) that occur during anaesthesia and operation. Methods of assessing these movements are reviewed and a simple model is used to illustrate the actions of the muscle groups involved, which are: the diaphragm, those of the rib cage, and of the abdomen. The control of these muscle groups, the forces that they generate, and the movements that can result are discussed. It is not possible to infer the action of these muscle groups from surface measurements alone. In particular, rib cage and abdominal movements do not necessarily indicate the separate actions of rib cage muscles and diaphragm. The changes in volume that occur in the chest wall on induction of anaesthesia are reviewed. The pattern of chest wall movement in the conscious subject, during anaesthesia with either spontaneous or artificial ventilation, and after operation is described, and the mechanisms of the changes that occur are discussed. Aspects of movements in respiratory failure and muscle fatigue are introduced.
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PMID:Chest wall movements in anaesthesia. 265 39

We reported a case of halothane-induced fulminant hepatitis with acute renal failure which developed 6 days after reexposure to halothane. The patient was a 58-year-old female. She had a history of liver dysfunction after exposure to halothane 6 years previously. She had surgical treatment of clubfoot under halothane anesthesia in other hospital. Preoperative physical examination and laboratory data were normal. On the 6th post-operative day she abruptly developed high fever and general fatigue. Next day, she was transferred to our hospital. At admission, fulminant hepatitis complicated with acute renal failure was diagnosed with severe liver and renal damage. She was immediately treated with plasma exchange, glucose-insulin therapy, and hemodialysis. Serum transaminase level returned to normal value within a week. However, despite repeated hemodialysis, renal function did not improve, and she died of P. aeruginosa sepsis on 28th day after the operation. It may be suggested that in this patient hypersensitivity to halothane has persisted during the six years.
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PMID:[A case of fulminant hepatitis after reexposure to halothane six years later]. 281 Jul 19

Labetalol is a unique antihypertensive agent which is a competitive peripheral antagonist at both alpha- and beta-adrenoceptor sites. Clinically, it possesses about one fourth of the beta-adrenoceptor blocking activity of propranolol and one half of the alpha-adrenoceptor blocking activity of phentolamine with a beta- to alpha-blocking ratio of approximately 7:1. Nowadays, the clinical profile of labetalol is clearly defined. Perorally, it has often been used in the treatment of mild, moderate and severe hypertension and intravenously in the management of hypertensive emergencies. It offers many advantages over beta-blockers with no prominent side-effects. Hemodynamically, labetalol reduces blood pressure, heart rate and, first of all, peripheral resistance with almost no change in resting cardiac output or stroke volume. Labetalol appears to be useful particularly in patients whose blood pressure is not adequately controlled by beta-blockers alone or combined with a diuretic, but sometimes at the expense of postural hypotensive side-effects. It has proved to be safe in patients with coronary artery disease or after acute myocardial infarction and in pregnant patients, but in phaechromocytoma further clinical experience is needed. In induced hypotension during anesthesia and surgery no invasive blood pressure measurements are needed. The most frequent adverse effects include fatigue, postural hypotension, headache and gastrointestinal complaints. On the whole, labetalol expands the armamentarium of the practising physician in the treatment of hypertension of different origin.
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PMID:Current status of labetalol, the first alpha- and beta-blocking agent. 286 49

The oculocardiac reflex (OCR), a previously undescribed phenomenon in aesthetic blepharoplasty surgery, involves intraoperative bradycardia exceeding 10 percent of the preoperative heart rate or any dysrhythmia during ocular manipulation. It is a trigeminal-vagal-mediated reflex arc. The oculocardiac reflex was noted to occur in 25 of 100 patients (25 percent) undergoing blepharoplasty. A data sheet designed and distributed for use in the operating room identified a reflex-prone patient (RPP) as a young, anxious female, with a cardiac history, operated on under light anesthesia with aggressive fat pad resection. The oculocardiac reflex was more likely to occur in a reflex-prone patient during traction on the medial fat pads and in the left eye. Despite anticipating the fatigue phenomenon in those patients who exhibited a profound bradycardia (35 to 40 beats per minute), it was necessary to release traction in order to permit the heart rate to return to normal. Awareness and treatment of this potentially life-threatening oculocardiac reflex are necessary. Careful patient surveillance and monitoring are mandatory.
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PMID:The oculocardiac reflex in blepharoplasty surgery. 291 23

This data, along with data from other research studies, indicate that PDT is a promising new treatment for noninvasive bladder cancer. In the current study at Veterans Administration Medical Center, three of the four patients who received Thiotepa have had recurrences of their bladder tumors or positive urine cytology. The three patients who received PDT have not experienced any recurrences or positive urine cytology. Since we have been involved in this trial, we have developed some recommendations that other institutions may want to follow. The tip of the laser fiber is very bright. To decrease eye strain and fatigue, a lens cap with a green eye shield should be used on the cytoscope. All staff should wear green-colored safety eye glasses. This will protect their eyes from constant exposure to the intense incandescent radiation, and if the fiber should break, it would protect their eyes from the bright red color. With all the extra equipment such as ultrasound, power meters, light sources, and anesthesia equipment, it is important to avoid tripping over extension cords. The cords should be covered. Also, it is important not to bump into the equipment, which can happen because the OR is dark. At this time, the laser technician is the only person authorized at our medical center to operate the argon-pumped tunable dye laser. In the future, if more research programs are started or therapy is approved for other uses, additional personnel will be trained.
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PMID:Photodynamic laser therapy. A bladder cancer protocol. 304 9

In experiments on 10 adult anaesthetized cats (pentobarbital 30 mg.kg-1 i.p.) the effect of stimultaneous hypoxia and hypercapnia was studied on the defence respiratory reflexes of the airways. Expiratory reflex and cough were elicited by mechanical stimulation of the airways mucosa, and the obtained values were evaluated on basis of the intrapleural pressure. Inhalation of the hypoxic-hypercapnic gas mixture (11% + 7% CO2 in N2) for 15 minutes led to a significant decrease of respiratory frequency, tidal volume and PaCO2, while pHa and PaCO2 also decreased significantly together with the intensity of the expiratory reflex and that of cough. Recent studies, showed that in the course of the effect of hypoxia (11% O2) and of hypercapnia (5% CO2), cough intensity decreased, but the change was not significant. The decrease of the intensity of respiratory defence reflexes under hypoxic-hypercapnic conditions might have been due to the changes of centrally controlling structures, or to the effector part of the reflex arc, resulting from fatigue of the respiratory muscles. The possible effect of anaesthesia exerting a significant influence on the intensity and character of airways defence reflexes could not be excluded.
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PMID:Effect of hypoxia and hypercapina on the airways defence reflexes. 312

A technique is described for studying the physiological function of canine skeletal muscle in vivo. The contractile properties of the tarsal flexor muscles were examined in three beagle dogs under general anaesthesia. The force responses to electrical stimulation of the common peroneal nerve were measured at various frequencies to determine the frequency:force relationship for this muscle group. Fatigue characteristics were also examined during intermittent stimulated activity delivered in a set pattern of frequencies. The results provide quantitative characterisation of muscle function which is repeatable. The technique described could be applied to other animals and is a potentially powerful tool for evaluating the effects of drugs on muscle performance.
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PMID:Technique for physiological examination of canine skeletal muscle in vivo. 322 45

The semitendinosus, the gastrocnemius and the soleus muscle were stimulated in situ in young, female domestic pigs (Sus scrofa domestica, German Landrace) and in European wild pigs (Sus scrofa scrofa), by supramaximal impulses via the sciatic nerve. Fatigue indices of the whole muscles were registered during a continuous supramaximal stimulation with square wave impulses (0.3 ms) that were given for 10 s with a frequency of 100 Hz. In domestic pigs, fatigue indices of all three muscles were significantly (p less than 0.001) lower than in wild pigs. The extremely rapid fatigue of domestic pig muscles was remarkably different from that measured in wild pigs, comparing either pigs of nearly the same body weight (FI: 22.7/58.6 for the semitendinosus muscle; 28.5/63.7 for the gastrocnemius muscle; 37.7/81.2 for the soleus muscle), or pigs of nearly the same age (FI: 23.1/58.8 for the semitendinosus muscle; 25.9/65.1 for the gastrocnemius muscle; 33.6/81.4 for the soleus muscle). Doses of anaesthetics needed for appropriate general anaesthesia of young wild pigs were two to three times higher than doses used for domestic pigs. Differences in fiber type composition of the muscles, and alterations in signal transmission characteristics at neuromuscular junctions are discussed as to be associated with the extremely low fatigue resistance of the domestic pig muscles.
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PMID:Fatigue of three skeletal muscles in domestic and wild pigs. A comparative study in situ. 339 63


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