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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

More than 1200 patients who received pindolol for the treatment of hypertension, angina pectoris, and various arrhythmias in studies conducted in the United States were included in the New Drug Application submitted to the FDA. Nearly 1000 of these patients received pindolol as monotherapy. The side effects reported were generally transient and of mild or moderate severity. The most frequently reported side effects seen after pindolol administration, compared to those seen after placebo, were in decreasing order of incidence: headache, dizziness, insomnia, muscle pain, fatigue, weakness, nervousness, joint pain, edema, nausea, and muscle cramps. Other side effects that occurred more frequently with pindolol than with placebo but at a rather low incidence induced weight gain, bizarre dreams, visual disturbances, lethargy, and diarrhea. Nasal congestion, throat discomfort, nocturia, impotence, pruritus, anxiety, hypotension, bradycardia, and heart failure occurred only rarely. Of the 323 patients who received pindolol alone for the treatment of mild to moderate hypertension, only 20 (6.2%) were withdrawn from the study because of side effects. Overall, 3.4% of the patients treated with pindolol were withdrawn because of side effects, most of which involved the central nervous system, that is, insomnia, anxiety, dizziness, and headache. However, a few patients manifested some edema and weight gain while receiving pindolol alone. Review of the side effects data did not reveal a tendency for the incidence of side effects to be dose related. One placebo-controlled, double-blind study designed to evaluate the fixed dosages of 15, 30, and 60 mg in the treatment of mild to moderate hypertension suggested that only the incidences of insomnia and nervousness increased with increasing doses. However, these side effects were generally transient and of mild or moderate severity. The evidence indicates that pindolol has an acceptable safety profile and that any side effects that appear are generally well tolerated and disappear with continued treatment.
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PMID:Adverse reactions to pindolol administration. 704 82

Studies on prodromata of myocardial infarction (MI) and sudden cardiac death suggest that psychological experiences like 'general discomfort', 'fatigue/weakness', and 'emotional changes' are as frequently reported as 'chest pain'. A psychological survey - the 'Maastricht Questionnaire' (MQ) - was constructed to measure those prodromata. In several studies it was found that the MQ was positively associated with imminent MI, with MI, with the Type A coronary-prone behavior pattern, and with reported stressful life changes. These associations do not appear to be confounded by somatic risk factors, thus implying to measure an independent psychologic constellation.
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PMID:Factors contributing to the development of vital exhaustion and depression in male myocardial infarction patients. 718 61

Follow-up results of two series of patients, one group of 50 vagotomy-antrectomies and another of 100 vagotomy-pyloroplastie, were compared after an average of 2,5, and 10 years. Nutrition, the capacity for work, and resistance to fatigue were better after pyloroplasty. After antrectomy there is a progressive decrease in nutrition, body weight varying by 2.730 kg. Digestive discomfort occurs after pyloroplasty, however, and does not improve with time : about half of the patients complain of post-prandial heaviness. Anastomotic ulcers are observed in 6 p. cent of patients after pyloroplasty, and 4 p. cent after antrectomy. Relapses after pytoroplasty occur at an early stage and are mainly due to failure of the vagotomy ; in this series their level remained stable. Phytobezoar is an elective complication of pyloroplasty and was noted in 4 p. cent of cases. The need for repeat operations (4 p. cent of cases) was identical in both groups.
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PMID:[Duodenal ulcers. Vagotomy-antrectomy or vagotomy-pyloroplasty. Comparison after ten years (author's transl)]. 721 36

In a prospective study, 68 hospitalized patients were diagnosed as having giant cell arteritis. Temporal artery biopsy was performed in all patients and showed histologic evidence of arteritis in 42 (62%). Twenty-six patients had a negative biopsy but met the clinical criteria for the diagnosis. Four different clinical pictures were recognized. Thirteen patients (19%) had symptoms of localized temporal arteritis without muscular discomfort. The polymyalgia rheumatica syndrome without signs of localized arteritis was seen in 33 patients (49%). Seventeen (25%) had symptoms of both polymyalgia rheumatica and temporal arteritis. Five patients (7%) had general symptoms only, such as fever, anorexia, and fatigue, without muscular or arteritic symptoms.
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PMID:The clinical pictures of giant cell arteritis. Temporal arteritis, polymyalgia rheumatica, and fever of unknown origin. 735 May 59

A 20-year-old female was brought to our emergency unit with generalized erythema and discomfort induced by running after having eaten wheat bread. The laboratory examinations, including eosinophils, total IgE, RAST score to wheat, heat challenge test and methacholine inhalation test were within normal limits. No anaphylactoid responses occurred after provocation tests of wheat bread intake or exercise alone. However, on provocation exercise test after eating pancakes, she developed hypotension, generalized itching and urticaria associated with an elevation of plasma histamine levels. These findings suggested wheat-dependent exercise-induced anaphylaxis. This was completely prevented by daily administration of terfenadine 120 mg p.o. without side effects such as fatigue or drowsiness.
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PMID:Successful prophylaxis of wheat-dependent exercise-induced anaphylaxis with terfenadine. 749 78

Fatigue is the most frequently reported symptom of patients with cancer. The purpose of this study was to describe the experience of fatigue over time in patients with cancer receiving treatment with interferon alpha. Piper's Integrated Fatigue Model guided this study. A descriptive repeated-measures design was used. A convenience sample of 30 patients with malignant melanoma was drawn from a comprehensive cancer center in Southern California. Two instruments were used in data collection, the Symptom Distress Scale and the Piper Fatigue Scale. Study findings revealed descriptive data on patients' perceptions of the causes and remedies for fatigue while receiving active treatment for cancer. The pattern of fatigue was consistent over the five points of time during treatment, with the most extreme fatigue scores in the affective domain, followed by the sensory, temporal, total fatigue, and fatigue severity scores. The patterns and dimensions of fatigue provide implications for care of patients receiving interferon alpha, and for further investigation in the area of fatigue as a critical aspect of quality of life.
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PMID:Fatigue in patients with cancer receiving interferon alpha. 759 73

Influences of physical and psychosocial work environments and personal factors on sick building syndrome symptoms were investigated in 167 clerical workers before and one year after moving from a naturally ventilated building to an artificially ventilated building. Female gender and work on visual display units were independently associated with most symptoms in the baseline survey and with the incident (new) symptoms in the follow-up survey. After changing buildings, the prevalences of eye, skin and fatigue symptoms increased significantly. Cold and discomfort due to stuffiness were independently associated with incident eye and respiratory symptoms. Reported domestic workloads were greater for women, but did not account for any gender differences in symptom prevalence.
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PMID:Sick building symptoms in office workers: a follow-up study before and one year after changing buildings. 770 66

To determine whether images can stimulate brainstem reflexes directly, parotid salivation was measured bilaterally in 24 subjects when they imagined, and actually tasted, a sour taste on one side of the tongue. Salivation increased in both cheeks during unilateral gustatory stimulation; furthermore, the response was greater on the stimulated side than contralaterally, indicating that the gustatory reflex has a unilateral component. Subjects imagined the sour taste more clearly after actually experiencing it. However, salivation did not increase significantly during imagery trials, either before or after exposure to the sour taste; in fact, salivation to imagery decreased below baseline after exposure. These findings suggest that extraneous factors (e.g. the emotional connotations of images, anxiety, discomfort, repetitive measurement or fatigue) might sometimes inhibit specific reflex activity induced by images.
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PMID:Effect of imagining and actually tasting a sour taste on one side of the tongue. 771 18

EMG spectral shifts of anterior temporal and medial masseter muscles were evaluated. Mean power frequency (MPF) shift during fatigue and recovery of 46 healthy subjects and 46 patients with craniomandibular disorder were recorded at the beginning and the end of fatiguing clenching, then 3, 8, 13 and 18 min following the fatiguing clenching. The reference clenching force was 80% of each subject's maximal voluntary contraction (MVC). Recording was stopped when subjects felt pain or discomfort. Significance was found between the healthy group (N) and the diseases group (CMD) in the three following points: (i) the mean of MPF values of the masseter muscles at the end of fatiguing clenching; (ii) the recovery pattern of the temporal muscles; and (iii) MPF shift induced by fatiguing clenching. Our results therefore suggest that MPF reflects several aspects of craniomandibular disorders. Thus, measuring fatigue and recovery MPF could be useful in the screening of CMD.
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PMID:Mean power frequency shift during fatigue and recovery in patients with craniomandibular disorders. 772 48

The studies covered changes in functional state of 42 programmers working at VGA. All the examinees reported subjective evaluation of fatigue and variational pulsometry before and after the work at VGA, those who worked at the display for 3 hours underwent blood pressure and pulse rate measurements (with subsequent calculation of several hemodynamic parameters) before and after the work. The researchers applied Major Components Method to obtain some integral parameters. The obtained values described initial state of cardiovascular system and changes in autocorellation of some BCG intervals. The fatigue was proved to occur by the end of the second working hour, and by the end of the third hour the examines demonstrated unfavorable changes of functional state (depression of heart activities and increased blood pressure). Only those who worked over 4 hours reported discomfort, so functional disorders appear earlier, than individuals detect them.
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PMID:[Physiologic evaluation of permissible work timing at the video display]. 772 32


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