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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Some musculoskeletal conditions that are prevalent in occupations where the handling of materials and/or tools is required have been linked with the musculoskeletal load that results from activities that are undertaken to fulfil that occupation. The excessive loading of muscles under these conditions may lead to local muscle fatigue which may, in turn, manifest as pain, localized discomfort or kinaesthetic dysfunction. Local muscle fatigue is recognized as a precursor to some of these musculoskeletal conditions. This paper postulates the probable physiological mechanisms that provoke it. The changes to intramuscular blood flow during contraction, and their significance in relation to local muscle fatigue, are also reviewed. Methods to measure local muscle fatigue, as well as their objectivity and practicality, are discussed together with their plausible clinical implications.
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PMID:Local muscle fatigue. A precursor to RSI? 353 87

Thirty-one patients with primary dysmenorrhoea were treated in a double-blind, six-period, cross-over clinical trial with tiaprofenic acid, naproxen sodium and a placebo in randomized order, each for 2 consecutive cycles. Complete disappearance of the symptoms or pronounced therapeutic effects were obtained with tiaprofenic acid, naproxen sodium and the placebo in 74%, 65% and 35% of cases, respectively, while these treatments were ineffective in 3%, 6% and 38% of cases, respectively. Tiaprofenic acid was superior to the placebo for relieving pelvic pain and overall discomfort and for reducing the need for bed-rest. Naproxen sodium compared favourably with the placebo with respect to pelvic pain and overall discomfort. The effects of tiaprofenic acid and naproxen sodium were not significantly different. Tiaprofenic acid had no side-effects, whereas tiredness was experienced in 3 cases of naproxen sodium treatment. The results indicate that tiaprofenic acid is a useful alternative for the treatment of primary dysmenorrhoea.
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PMID:Tiaprofenic acid in the treatment of primary dysmenorrhoea. 353 72

Pregnancy and the puerperium herald dramatic and complex physiological, psychological, interpersonal, and sexual changes in a woman and in the marital process. Pregnancy tends to have an increasingly negative effect on sexual desire, expression, and satisfaction as term approaches. Clinical variables discussed include anatomic and physiological changes, puerperal sexual response patterns, marital adjustment, body image, dyspareunia related to episiotomy, lactation, and traditional taboos and cautions regarding coitus for the new mother. Most research respondents reported gradual return to prepregnancy levels of sexual desire, enjoyment, and coital frequency, with a minority in most cited studies indicating sexual interest and coitus levels below prepregnancy levels up to 1 year after delivery. The most frequently listed reasons for poor postpartum sexual adjustment include episiotomy discomfort, fatigue, vaginal bleeding or discharge, dyspareunia, insufficient lubrication, fears of awakening the infant or not hearing him/her, fear of injury, and decreased sense of attractiveness. Postpartum counseling should be offered prior to hospital discharge.
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PMID:Sexuality in the puerperium: a review. 359 63

Animal studies suggest that pulmonary oxygen toxicity proceeds more slowly in diluted oxygen breathing mixtures than in pure oxygen at the same inspired partial pressure. We exposed 12 healthy subjects to air at 5 ATA (PiO2 = 1.05 ATA) in a hyperbaric chamber for 48 h, and compared the rate of development of symptoms of O2 toxicity to rates seen in previous studies using 100% O2 at 1 ATA. Symptoms consisted of chest tightness, cough, substernal discomfort, exertional dyspnea, anorexia, nausea and vomiting, headache and digital paresthesias starting at about 12 h, and continuing several days into the recovery period. Pulmonary function changes consisted of significant decrements in vital capacity, flow rates, and DLCO. Initial recovery was in a 0.50 ATA oxygen atmosphere, with the majority of subjects showing definite recovery in both symptoms and pulmonary function. Subjects showed complete recovery in about 8 d, although symptoms of fatigue and exertional dyspnea continued for a month in some cases. In contrast, none of the above changes were noted in an additional 6 subjects exposed to a 5 ATA environment with 6% oxygen (PiO2 = 0.30 ATA). No change in resting gas exchange, as indicated by alveolar-arterial oxygen gradients, was detected in either group. Comparison of these data to that for pure oxygen studies reveals no significant difference in the progression or character of pulmonary oxygen toxicity.
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PMID:Progression of and recovery from pulmonary oxygen toxicity in humans exposed to 5 ATA air. 361 41

A nationwide survey of workers using videodisplay terminals (VDT) was conducted and the data of various health complaints were compiled for a total of 5,097 VDT workers in 23 types of enterprises. Various symptoms or complaints were classified into transient and persistent groups, and attempts were made to determine their causal factors in the working conditions. In the transient complaint group, complaints of the visual function were the most frequent, followed by musculoskeletal and neuropsychological complaints; this indicated that visual loads from the VDT screen and musculoskeletal loads from a fixed working posture constituted the major causes of the complaints. Troublesome factors for the VDT work mainly embraced characteristics of the VDT screen, such as reflection of light, inadequate brightness and blurred margin of the letters, etc, and the arrangement of VDT, documents and keyboards. In the persistent complaint group, neuropsychological complaints appeared most frequently followed by complaints of the visual function and general body discomfort or fatigue. Mental attitude and motivation to the VDT work diverged, at a similar incidence, into two opposite groups, ie, interesting and bored. The complaints of various categories, ie, visual, musculoskeletal, neuropsychological and general body fatigue, were correlated with the working conditions: environmental conditions played a major role in the manifestation of these complaints. On the basis of these analyses, preferable measures were proposed to reduce complaints among VDT workers.
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PMID:Visual, musculoskeletal and neuropsychological health complaints of workers using videodisplay terminal and an occupational health guideline. 362 75

To assess perceived changes in intimacy and sexuality in postpartum couples, an Intimate Relationship Scale was developed, tested for reliability (alpha = 0.86), and administered by mail. Sixty-eight, middle-class couples responded at four months postpartum and 126 couples at 12 months postpartum. Data revealed declines in the frequency of and desire for sexual activity, especially for mothers, when compared to sexual activity before the infant's birth. At four months postpartum, most women reported physical discomfort with sexual intercourse, a decline in physical strength, dissatisfaction with bodily appearance, and fatigue which interfered with sex. Strategies and techniques to promote and maintain intimacy and sexuality in postpartum couples are suggested to assist their transition to parenthood and may positively influence parenting behaviors.
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PMID:Changes in sexual relationships in postpartum couples. 363 3

Parenthood by design involves realistic preparation for practical aspects of parenting as well as the romantic illusions fostered by relatives, social pressure, and the media. The ideals do not mention the physical discomfort, exhaustion, jealousy, anger and frustration encountered in a normal puerperium. Many women have not returned to normal sexual activity, work and sports even by 6 weeks after delivery. Perineal discomfort is still experienced by 70% after 10 days, especially in cases of assisted vaginal delivery. Urinary incontinence is present in 20% up to 3 months after normal vaginal delivery. Many women report fatigue as the reason for not resuming sexual intercourse. Family interactions are stressed by the newcomer: rivalry on the part of the husband or siblings is common. Modern education in the attempt to train people for vocational competence has left out parenting. In England, midwives teach classes of 20 women for 5 contact hours in late pregnancy, and are expected to cover all aspects of pregnancy, labor, delivery, baby care, postnatal adjustment and support services. The schools have sex education, fostering freedom in life styles for young people, but little emphasis on responsibility. There are some community organizations such as the La Leche League, the National Childbirth Trust and the Meet-A-Mum Association that offer support during and after pregnancy. Accidental pregnancy with education as crisis intervention is inadequate for the future; parenthood by design would permit couples to experience parenthood as a period of growth based on a fuller understanding of practical reality.
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PMID:Parenthood by design. 363 45

The pattern of newborn handling by 36 cesarean-delivered women and 36 vaginally delivered women was studied during their infants' first postpartum bedside visit. The research hypothesis predicted that the initial pattern of handling newborn infants would be different for the two groups of mothers. However, the pattern was found to be similar for the time it took both groups to initiate using their fingers, palms, arms, and trunks, as well as the sequence of use of these body parts, although neither group followed the sequence of handling reported in the bonding literature. The two groups did differ in the frequency and amount of handling of the infants: the cesarean mothers handled their infants significantly less, possibly due to the effects of fatigue and discomfort. In addition, the presence of the infant's father in the cesarean group had a significant effect of decreasing the frequency and amount of maternal handling. No such effect was found in the vaginally delivered group.
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PMID:Initial handling of newborn infants by vaginally and cesarean-delivered mothers. 363 10

The incidence of physical toxicity and psychosocial effects associated with adjuvant chemotherapy for stage II breast cancer have been reported in previous studies. The purpose of this exploratory study was to quantify the degree of physical and psychologic distress experienced by patients and identify life-style changes. A semistructured interview was conducted with 78 subjects to elicit demographic data, distress, and life-style changes using the Symptoms Distress Scale (SDS), the Psychiatric Status Schedule (PSS), and questions and scales developed by the investigator. All subjects received adjuvant chemotherapy (cyclophosphamide, methotrexate, and 5-fluorouracil with or without vincristine and prednisone) following primary treatment for breast carcinoma. Fifty subjects were currently on therapy and 28 had completed treatment. Fatigue was the most distressful physical symptom. Although physical distress was rated higher by subjects receiving treatment, generally all rating scores indicated only mild symptom distress. Subjects perceived more distress for the psychologic and emotional response to disease and treatment, and this persisted for women who completed therapy. Changes in role performance and daily activity were minimal.
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PMID:Physical and psychologic distress associated with adjuvant chemotherapy in women with breast cancer. 375 73

Clinical studies were prospectively conducted to quantitate the toxic side-effects of 5-FU administered by either the intravenous (i.v.) or intraperitoneal (i.p.) route. Sixty-six patients were treated following resection of a primary large bowel cancer after randomization to receive 5-FU by i.p. or i.v. routes. In both groups of patients, the dose of drug was increased a fixed amount until a toxic response occurred. At this point, the dose of drug was maintained or reduced in an attempt to complete 12 monthly treatment cycles of chemotherapy. The overall mean dose of drug administered by the i.p. route (1,479 mg) was significantly greater than given i.v. (1,019 mg), as it was for each treatment cycle. The primary adverse side-effect, resulting in drug dose stabilization or reduction, was leukocyte suppression of i.v. 5-FU or physical symptoms (abdominal pain or discomfort) for i.p. 5-FU (p2 = 0.0006 and p2 = 0.0318, respectively). The most frequent symptom reported by all patients was fatigue. Even though i.v. 5-FU dose was titrated to reduce toxicity, the nadir leukocyte count was suppressed over all cycles. The total numbers of immediate and delayed serious complications that resulted from i.v. or i.p. 5-FU were similar, although the nature of these complications differed markedly between the two routes of drug administration. Failure to complete 5-FU chemotherapy was significantly more common if patients received i.v. 5-FU plus pelvic irradiation. These studies indicate that intraperitoneal 5-FU administration decreases systemic drug effects even when the i.p. drug dose is increased to cause local toxicity.
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PMID:Toxicity studies of adjuvant intravenous versus intraperitoneal 5-FU in patients with advanced primary colon or rectal cancer. 377 3


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