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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Tiapride was used in 55 chronic alcoholics. It has a sedative effect on the anxiety, aggressiveness and agitation observed during the alcohol withdrawal syndrome. It is also effective against tremor, insomnia and fatigue. Fatigue or depression do not occur as side-effects. Tiapride induces a psychological feeling of wellbeing which is heightened by continuation of detoxication and general management.
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PMID:[Tiapride in detoxication of chronic alcoholics (author's transl)]. 627 32

In a Finnish general practice 120 patients with psychosomatic disorders, manifest as syndromes of tension headache, cardiac neurosis, dizziness or muscular tension, were randomly allocated to treatment over a 4-week period with either flupenthixol (1 to 2 mg per day) or diazepam (5 to 10 mg mg per day). The 4 syndromes and 12 associated symptoms (anxiety, fatigue, depression, pain, asthenia, muscle fatiguability, tension, dyspnoea, restlessness, palpitations, sleep disorders, and vertigo) were rated on a 4-point scale on entry, at 2 weeks and at 4 weeks. Both drugs reduced significantly the average total scores for syndromes and single symptoms after 2-weeks' treatment. Flupenthixol was the more effective in relieving fatigue and vertigo; diazepam in relieving headache, anxiety, tension, restlessness and sleep disturbance. Cardiac neurosis, palpitations and general muscular tension responded poorly to both drugs. After 4 weeks, relief of vertigo, pain and fatigue was more evident in the flupenthixol group, and of anxiety, tension and restlessness in the diazepam group. Side-effects were complained of at some stage by 17 patients in the flupenthixol group (9 of fatigue, 5 of sleep disturbance, 1 of constipation, 1 of extrapyramidal symptoms, and 1 of weight gain) and by 16 patients in the diazepam group (10 of fatigue, 4 of sleep problems and 2 of diarrhoea).
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PMID:Flupenthixol versus diazepam in the treatment of psychosomatic disorders: a double-blind, multi-centre trial in general practice. 637 78

We studied diaphragmatic muscle function during inspiratory flow resistive (IFR) loaded breathing in unanesthetized sheep. We measured the change in transdiaphragmatic pressure (dPdi) and arterial blood gas tensions and recorded diaphragmatic electromyogram (EMG) from electrodes implanted on the muscle. We found that, with IFR loads less than 150 cmH2O X l-1 X s, dPdi and the integrated EMG increased, reached a plateau, and were maintained at high levels. The centroid frequency (fc) of the EMG power spectrum did not consistently change. With IFR loads greater than 150 cmH2O X l-1 X s, O2 was administered to prevent hypoxia, cyanosis, and agitation. With these loads, dPdi increased severalfold above base line, reached a plateau, and then started to decrease. Arterial PCO2 increased sharply at the time when dPdi decreased. The integrated EMG (iEMG) and fc started to decrease gradually 10-20 min before dPdi started to decrease. We conclude that 1) the diaphragm is capable of generating large pressures for prolonged periods with no evidence of fatigue; 2) with very high IFR loads, mechanical failure of the diaphragm can occur in the unanesthetized awake sheep; 3) diaphragmatic fatigue is associated with acute hypercapnia and therefore failure of the entire respiratory pump; and 4) a decrease in iEMG and a concommitant shift in the power spectrum density towards lower frequencies precede the mechanical failure of the diaphragm.
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PMID:Diaphragmatic fatigue in unanesthetized adult sheep. 646 79

We interviewed and neurologically reexamined 94 patients who had previous pneumococcal meningitis. The findings were allocated into groups with and without a causal relationship to the meningitis. The main sequelae after meningitis were dizziness (23%), tiredness (22%), mild memory deficits (21%), and gait ataxia (18%), whereas other focal neurologic signs were rare. By a rating (0 to 5) of the presence and severity of sequelae after meningitis, 54% of the patients were found to have sequelae. The clinical condition at the time of acute illness was studied in subgroups of patients who had different neurologic sequelae or high sequelae ratings. Gait ataxia was associated with a state of agitation and confusion when the patient was admitted for meningitis. High sequelae ratings on reexamination were associated with an affected consciousness at the acute stage of the disease and with high numbers of WBCs in the CSF at the time of hospitalization.
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PMID:Pneumococcal meningitis. Late neurologic sequelae and features of prognostic impact. 647 11

Data on self-reported symptoms of ill-health were collected from 1500 respondents, and factor analysed. The results of this analysis suggested a two factor orthogonal model of well-being: one factor reflecting fatigue, emotional fragility and confusion (worn-out) and the other tension, anxiety and agitation (up-tight). The reliability and validity of the model were tested and appeared acceptable, and scales were constructed for the assessment of the two factors. It is suggested that the model and the associated scales could offer new information in studies of occupational stress and health.
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PMID:The nature and assessment of general well-being. 666 61

The pharmacology, pharmacokinetics, clinical trials, side effects, and dosage of amoxapine are reviewed. Amoxapine is a tricyclic dibenzoxazepine antidepressant that is chemically similar to the antipsychotic agent loxapine. In animal tests, amoxapine and its metabolites block reuptake of the neurotransmitter norepinephrine, with little effect on serotonin. It is rapidly and virtually completely absorbed when administered orally; peak serum concentrations occur one to two hours after ingestion. Amoxapine is widely distributed throughout body tissues and is 90% bound to serum proteins. Aromatic hydroxylation in the liver produces two major metabolites, which are excreted in the urine primarily but also in the feces. Amoxapine's elimination half-life is eight hours; one of the metabolites has a long half-life (30 hours). In clinical trials, amoxapine has been compared with amitriptyline and imipramine in several types of depressed patients. In some studies, amoxapine's therapeutic effects were measurable earlier (at one or two weeks after initiation of therapy) than those of the amitriptyline or imipramine, but generally only a portion of the depression-rating scales yielded statistically significant differences. Side effects noted during amoxapine therapy include hypotension (42%), drowsiness (14%), xerostomia (14%), constipation (12%), blurred vision (7%), fatigue (5%), and vertigo (5%). Amoxapine is approved by FDA for use in patients with neurotic or reactive depressive disorders, endogenous or psychotic depression, and depression accompanied by anxiety or agitation. The usual adult dosage is 200-300 mg daily, either in divided doses or a single bedtime dose. Amoxapine is a safe and effective antidepressant with no striking advantages over other available agents.
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PMID:Evaluation of amoxapine. 676 65

A stress questionnaire was developed and administered to employees and students participating in a stress program. The questionnaire consists of three components: stressful conditions, stress symptoms, and measures used to relax. The present study focused on the validation of the stressful conditions portion. Factor analysis demonstrated that the questionnaire had three meaningful factors. Based on the analysis, composite scores were obtained reflecting these three dimensions. Alpha reliability analysis demonstrated that each of the factors was reliable at an acceptable level (r greater than .80). The first factor represented an organizational or external cluster, while the second factor reflected an internal or personal construct. The first factor was shown to correlate negatively with fatigue, worry, agitation, impatience, anger and similar symptoms, while the second factor correlated positively with these complaints. Studies of group differences revealed that defined occupational groups differed on scores for all portions of the questionnaire. In addition, groups participating in a stress management course changed significantly on the first two factors. The third factor related to handling conflict and contained only a few items. Replication studies showed that the factors were stable across different versions of the scales with different groups. The results suggest that the assessment method may be promising for future studies on stress management.
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PMID:Stress management: an assessment questionnaire for evaluating interventions and comparing groups. 717 87

The complaints of 400 patients who were sent by their general practitioners to our hospital are enumerated in table 1 according to thier frequency (33 items). Three groups of complaints stand out: a) disturbances of memory and concentration b) nervousness - inward restlessness - increased irritability c) fatigue - decrease of performance. In the earlier literature similar syndromes were described as signs of the diminution of cerebral performance. If they appeared in old persons they were considered as an expression of a (physio-logical?) decrease of neurons. In middle-aged men the same syndrome was considered as sign of a premature cerebral arteriosclerosis. Recent investigations have shown that a decrease of cerebral performance is often due to a degenerative process of Alzheimer's type. In many cases it is difficult to decide concerning which of the three basic processes we have to take into consideration if a diminution in cerebral performance occurs. Presented are: Cues for diagnosis, differential diagnosis and treatment of the syndrome often seen in general practice today.
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PMID:[So-called presclerosis (developing cerebral ischemia)]. 724 33

The effectiveness and tolerance of Lofepramine was investigated in a neurological practice on 100 patients with predominantly slight and moderately severe depressive states. The treatment could be carried out according to the trial plan on 78 patients and the success of the therapy could be evaluated. 67 patients showed definite improvement (85.9%) and tolerance was good to very good in 96.2% of the cases. Although a tranquilizaer was also administered to 62 patients, the success of therapy was definitely accounted for by the antidepressant. This applies particularly to the symptoms of fear, tiredness and impairment of work capacity as well as "depressive mood", hypochondria, somatization and states of agitation. No serious side effects were observed in any patient. Insufficient success in therapy was observed most often when the minimal dose of 35 mg per day was administered, while convincing results were obtained by a dosage of 70 to 140 mg of Lofepramine daily. A large number of patients who were initially treated with higher doses of Lofepramine profited from a subsequent long-term therapy lasting several months during which 17.5 to 35 mg of Lofepramine were administered daily.
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PMID:[Results of treatment with the anti-depressive agent lofepramine in neurological practice]. 736 77

The following double-blind, randomised study dealt with three questions: (1) Is a multidimensional psychometric rating scale suitable for the measurement of mood before anaesthesia? (2) What are the effects of the new benzodiazepine-like drug zolpidem on preoperative mood compared with phenobarbital? (3) Is the combination with Promethazine suggestive? METHODS. Three hundred and four patients were assigned to four groups (group 1: zolpidem 8.03 mg/promethazine 50 mg; group 2: zolpidem 8.03 mg/placebo; group 3: phenobarbital 100 mg/promethazine 50 mg; group 4: phenobarbital 100 mg/placebo). The drugs were given the evening before anaesthesia (09:30-10:00 p.m.). The sample was shifted by age and sex. Mood was measured by a multidimensional rating scale, which assessed aspects of elated mood, anxiety, hostility, deactivation, vigilance, and introversion. Statistics were performed using analysis of variance (ANOVA). RESULTS. Zolpidem led to significantly higher expressions of hostility (negative mood, irritability, aggressiveness) than phenobarbital. Compared with placebo, promethazine led to greater deactivation (more tiredness and numbness, lower level of wakefulness). Specific emotions and somatic aspects were not affected. Patients who had received promethazine received a lower dose of thiopentone for induction of anaesthesia than patients with placebo. CONCLUSIONS. Zolpidem and phenobarbital have many common effects on preoperative mood. Differences were found in the unspecific emotional aspects of agitation and hostility. These negative effects must be weighed against the pharmacokinetic and pharmacodynamic advantages of zolpidem when this drug is administered for premedication. The effects of zolpidem seem to be more sedative than anxiolytic. The study shows that a combination with promethazine is suggestive, because promethazine has a selective deactivating effect. The finding that promethazine lowers the dose of thiopentone required for induction of anaesthesia is an additional interesting point. The results of this study highlight the importance of using multidimensional rating scales for the measurement of mood before anaesthesia.
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PMID:[Multidimensional psychometric assessment of preoperative mood. Effects of zolpidem compared to phenobarbital combined with promethazine as premedication]. 748 25


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