Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hearing loss induced in thirty female workers because of exposure to continuous noise was studied in a plastic bag plant in Samutprakarn Province, the largest industrial zone in Thailand. The sound level in this plant was 98.5 dBA., 94.0 dBA. and 93.0 dBA. in the weaving, winding and warping sections, respectively. Results of an audiometric test showed a significant relationship between high noise level and hearing loss at frequency 4,000 Hz. A questionnaire survey found that a relatively high number of workers had various symptoms such as: 76.7% general fatigue, 70% headache, 63.3% ear distension and 56.7% vertigo. Concerning the usage of ear protective devices, it was found that 80% of the workers have never used such devices, 16.7% occasionally used them, and 3.3% have always used cotton wool to reduce the high noise level. Their reasons for non-use of ear protective devices were 1) not provided by the employer (86.7%), 2) not necessary (83.3%), 3) accustomed to the noise (63.3%), 4) nobody uses (56.7%), and 5) no loud noise (16.7%). These results point to the need for improving the work conditions and welfare services of the workers at this plant. Also, hearing conservation programmes can be instituted in developing countries through cooperation among the safety inspectorate, the employer and the workers.
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PMID:The need for a participatory conservation programme for the reduction of noise exposure to Thai female workers. 263 11

A 30-year-old man was admitted because of fatigue, vertigo and 2 episodes of melena. Endoscopy showed a tumor in the gastric antrum which appeared benign, as was also its appearance on barium meal. The source of the bleeding was the mucosa overlying the tumor. Antrectomy was performed with Billroth I anastomosis. Histopathological examination revealed the tumor to be an ectopic pancreas in the gastric wall.
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PMID:[Ectopic pancreas in the gastric wall with massive bleeding]. 273 61

A scale to evaluate the withdrawal syndrome induced by tranquilizers (TWS) is proposed to distinguish between anxiety induced symptoms and withdrawal induced symptoms. This scale was established and validated by Lader, the french translation was performed by the author. The most frequently observed symptoms during a withdrawal syndrome are physical tiredness, headache, vertigo and tremor but other symptoms are evaluated by this tranquilizers withdrawal scale.
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PMID:[A scale for evaluating withdrawal symptoms induced by anxiolytic agents]. 290 55

Local UHF-hyperthermia (915 MHz) of cancer of the oral mucosa at advanced stages ensures higher immediate cure rates (48.9 +/- 7.5%) as compared to radiotherapy (26.8 +/- 6.9%). 30-min. hyperthermia before irradiation turned out more effective than 60-min. hyperthermia. Hyperthermia was attended by side-effects (fatigue and sweating, vertigo and pain in the zone of heating). Hyperthermia was not tolerated by 10.7% of patients. Fixed metal prostheses and crowns in the zone of planned hyperthermia should be removed.
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PMID:[Thermoradiotherapy of the late stages of cancer of the oral mucosa and oropharynx]. 291 29

Orbital venous vasculitis has been suggested to cause characteristic periorbital pain in patients with pathologic changes in their orbital phlebograms. The orbital pain is characterized by being unilateral, not shifting side, boring and pressing, but not throbbing, increasing on eye strain, exposure to cold, or weather changes, and resistant to analgesics. It is ameliorated by steroids. Fifty patients with symptoms of orbital venous vasculitis were investigated for other symptoms that could be related to the vasculitis. When the 32 female patients were compared with a randomly selected age- and sex-matched control group, there was a significant increase of symptoms of chronic fatigue, cold feet, gut problems such as constipation and/or diarrhea, arthralgia, memory impairment, rotatory vertigo, spontaneous ecchymoses (all, p less than 0.0001), back pain (p less than 0.012), and thrombophlebitis (p less than 0.022) in the patient group. These symptoms, although commonly occurring, seem in these patients to be related to the vasculitis. Blood tests of the fifty patients showed signs of inflammation which did not disagree with the hypothesis of an immunologic cause of the orbital venous vasculitis.
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PMID:Systemic symptoms associated with orbital venous vasculitis. 321 27

The investigations include job description and analysis of the activity, functional examinations of basic dynamometric indices (muscle strength and endurance of static effort), the pulse rate and the time of carrying out of one operation and for manufacturing of unit product. Psychological tests for subjective evaluation of the stress and monotony, the type and rate of vertigo, of the psychic status in the presence of monotony, are applied. The ergonomic analysis comprises evaluation of the work place work posture and equipment. The results of the investigations point out that the activity of the basic professions in this production is expressed monotonous, with significant static load of the muscle system and total hypokinesia and hypodynamia. Changes in the working capacity and fatigue are registered in the middle of the working day as well as disturbances in the neuro-vegetative and adaptation mechanisms of the organism and appearance of unfavourable psychic conditions (decreased vigilance, boredom, satiating). Ergonomic incongruities were found in the dimensions and the order of the working place and equipment.
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PMID:[Physiological, psychological and ergonomic research on jobs in the manufacture of chocolate products]. 324 3

Two groups of 15 women with moderately severe post-partum hypotension were assigned at random to receive treatment with either 200 mg dimetophrine or placebo, orally, over a period of 10 days. Systolic blood pressure increased steadily and significantly during the first 5 days of treatment, from 100.0 +/- 1.2 mmHg to 128.0 +/- 1.2 mmHg with dimetophrine; with placebo, the increase from 99.8 +/- 1.1 mmHg to 104.7 +/- 1.1 mmHg was significantly less. Similar results were observed in diastolic blood pressure measurements. Overall, all 15 patients responded to dimetophrine but only 4 spontaneously recovered on placebo. At the same time, heart rate moved towards normal with dimetophrine (from 82.4 +/- 2.0 to 75.5 +/- 1.1 beats/min); with placebo, significantly less recovery was observed (from 79.5 +/- 2.3 to 78.6 +/- 1.5 beats/min). Concomitant with the recovery of perfusion pressure, the associated symptoms (asthenia, paleness, fatigue, dizziness, sweating, headache, vertigo) significantly decreased in intensity, all except vertigo to a significantly greater extent with dimetophrine than with placebo. Subjective tolerance was good in both groups; clinically relevant variations in haematological or haematochemical parameters measured were absent, except for the expected normalization of leucocyte count.
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PMID:Effective treatment of post-partum hypotension with dimetophrine: a placebo-controlled, double-blind trial. 389 65

The therapeutic efficacy and safety of oxiracetam (ISF 2522), a new nootropic cyclic GABA derivative, were investigated in a double-blind, placebo-controlled study in 40 patients with organic brain syndrome in late life. The psychopathology was characterized by memory deficits, intellectual dysfunction, lack of drive, and disturbance of affectivity. Patients were randomly assigned to a 4-week treatment with either 2 X 400 mg oxiracetam capsules t.i.d. or identical placebo capsules in the same dosing schedule. Evaluation of the psychopathology and side effects was carried out at weeks 0, 1 and 4; laboratory tests (hematology, blood chemistry and urinalysis), a battery of psychometric tests and quantitative EEG investigations were done at weeks 0 and 4. In the oxiracetam group a slight but significant improvement in global symptomatology was observed within 1 week, with further improvement after 4 weeks. In the placebo group, an improvement was seen only in the 4th week. Evaluation of the detailed psychopathology by means of the Sandoz clinical assessment geriatric scale (SCAG) showed in the oxiracetam group significant improvements in loss of appetite and vertigo after 1 week and in short-term memory, anxiety, emotional lability, fatigue, loss of appetite and vertigo after 4 weeks. In contrast, not a single item improved significantly during placebo treatment. Although the differences in SCAG scores between the two groups failed to reach statistical significance, the overall trend towards improvement was significantly better in the oxiracetam group. The tolerability of the drug was good.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Double-blind, placebo-controlled, clinical, psychometric and neurophysiological investigations with oxiracetam in the organic brain syndrome of late life. 389 95

Every time the tuberculosis is present and it is to be included in the differentialdiagnosis if the occasion arrises. In the anamnesis it is necessary to pay attention to specific diseases and the risk groups like patients with "21-day-cough", silicotics, "Contrast-articularis bronchitics", diabetics, so-called "persons with fibrotic lesions" and patients with frequent influenzal infections. The symptoms unclear gastric distress, want of appetite, indifferent loss in weight, uneasiness, slight vertigo and fast tiredness already give further references. Breath-pain, haemoptysis and subfebrile temperatures are already severe symptoms. A thorax X ray-photograph, tuberculin test, heamogram, sedimentation test and intensive search for mycobacteria, belong to the diagnosis. In extrapulmonary foci the search for mycobacteria is to try by swab, puncture, control of urine and menstrual blood. It is possible, that a histologic corroboration will be necessary. Unclear fever, headache and vomiting with or without dyspnoea, cyanosis and diaphragmatic lowness indicate a ocular reflection, liver biopsy and, in special case, a lumbar puncture without delay. Sooner or later the course of an unrecognized phthisis can result in death. It is necessary to fill up the gap between welltime diagnosis and death by unknown tuberculosis. That means: Thorough knowledge of matter, insight into the disease-course and inducement of all necessary diagnostic possibilities.
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PMID:[Diagnosis and course of tuberculosis especially from the viewpoint of clinically unknown deaths]. 407 12

In a Finnish general practice 120 patients with psychosomatic disorders, manifest as syndromes of tension headache, cardiac neurosis, dizziness or muscular tension, were randomly allocated to treatment over a 4-week period with either flupenthixol (1 to 2 mg per day) or diazepam (5 to 10 mg mg per day). The 4 syndromes and 12 associated symptoms (anxiety, fatigue, depression, pain, asthenia, muscle fatiguability, tension, dyspnoea, restlessness, palpitations, sleep disorders, and vertigo) were rated on a 4-point scale on entry, at 2 weeks and at 4 weeks. Both drugs reduced significantly the average total scores for syndromes and single symptoms after 2-weeks' treatment. Flupenthixol was the more effective in relieving fatigue and vertigo; diazepam in relieving headache, anxiety, tension, restlessness and sleep disturbance. Cardiac neurosis, palpitations and general muscular tension responded poorly to both drugs. After 4 weeks, relief of vertigo, pain and fatigue was more evident in the flupenthixol group, and of anxiety, tension and restlessness in the diazepam group. Side-effects were complained of at some stage by 17 patients in the flupenthixol group (9 of fatigue, 5 of sleep disturbance, 1 of constipation, 1 of extrapyramidal symptoms, and 1 of weight gain) and by 16 patients in the diazepam group (10 of fatigue, 4 of sleep problems and 2 of diarrhoea).
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PMID:Flupenthixol versus diazepam in the treatment of psychosomatic disorders: a double-blind, multi-centre trial in general practice. 637 78


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