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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Physical signs, medical history and social factors were analyzed and evaluated in 52 patients (17 women and 35 men) with chronic low back pain, in order to determine if any factors were predictive for return to work after rehabilitation. Factors discriminating between the working and sick-disabled groups were: Sex (only men returned to full time work), Duration of sick-leave (the older half of the study population exhibited a negative correlation between time on sick-leave and frequency of return to work), Reported need for analgesics (the working group reported less need of analgesics), Pain in the cervical and dorsal areas of the spine as well as in the lumbar region (less frequent in the working group), The patients' attitude to his own ADL-capacity (those who returned to full-time work were more positive), After work fatigue (less frequent in the working group).
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PMID:Clinical and social factors in rehabilitation of patients with chronic low back pain. 294 Jun 78

In order to determine the causal factors of low back pain (LBP) which prevails among freight-container tractor drivers, vibration measurements of the seat of ten freight-container tractors and one heavy truck, a survey on the daily working hours of 240 tractor drivers for a month, and a time study of work on 28 person-days were conducted. Vibration measurement was made under routine conditions on paved public roads for 40 km under laden and unladen conditions. For the evaluation of vibration exposure, ISO 2631 was used. With the freight-container tractors, the mean vibration levels were high in X and Z directions, particularly in X direction. In the heavy truck, the vibration level was consistently higher in Z direction. According to the evaluation made by ISO 2631, the X component of the vibration was found to be serious. The magnitude of the vibration level was greatly influenced by the condition of the road surface with bridges tending to produce a high level of vibration. Vibration levels of the new model tractors were not necessarily always lower than that of the old models. It was estimated from the foregoing results and the time study that in more than 90% of the drivers the daily exposure time (i.e. driving hours) exceeded the allowable exposure time of fatigue-decreased proficiency boundary (FDP), and in about one-third of the drivers the allowable exposure time of exposure limit (EL) was exceeded. These results suggest that long exposure to severe vibration during work is one of the possible causal factors of LBP of freight-container drivers.
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PMID:[The labor of freight-container tractor drivers and low back pain. Correlation with whole-body vibration exposure]. 295 Feb 61

The purpose of the present study was to determine whether patients with recurrent low back pain display a different pattern of mood fluctuations across days than matched healthy controls and whether these mood states are related to pain occurrence and/or magnitude using a prospective design. The questions addressed are whether mood states prior to a pain episode are associated with the episode or whether mood relates to pain as a secondary reaction. Similarly, the relationship between mood state recorded prior to, during or following pain and magnitude of pain experienced was investigated. Thirty-three ambulatory chronic low back pain patients and an equivalent group of asymptomatic controls matched for age, sex, socioeconomic status, and reported activity level monitored mood state (anxiety, tension, depression, anger, vigor, fatigue, confusion) and pain before breakfast, at 4 p.m. and at bedtime for 14 consecutive days. Groups were successfully matched. Analyses revealed significantly higher levels of tension, anxiety and fatigue and lower levels of vigor in the pain cases. No mood state was predictive of pain onset but fatigue was associated with pain 24 h following pain, indicating fatigue as secondary to pain. While mood state recorded prior to or following pain was unable to predict magnitude of pain, fatigue was associated with the level of pain experienced during the pain episode itself. The findings reveal a pattern of anxiety, tension and fatigue where fatigue is associated with increased pain during the pain episode and is increased 24 h following pain. This fatigue-pain relationship is superimposed upon a continuous elevation of anxiety and tension. These findings suggest the importance of pain management efforts directed at decreasing patients' fatigue levels, and increasing functional endurance while simultaneously reducing anxiety. The results also question the role of negative mood states in the initiation or exacerbation of pain and highlights the influence of physical mood states such as fatigue on pain in low back pain.
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PMID:A prospective analysis of stress and fatigue in recurrent low back pain. 296 55

This article evaluates the role of aerobic exercise in the treatment of low back pain and related disability. A regular exercise program can improve strength and endurance, prevent fatigue from causing improper body mechanics, increase beta-endorphin levels, reduce depression and give patients an overall feeling of well-being.
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PMID:Aerobic exercise in the treatment and prevention of low back pain. 296 86

Five cases of gastric carcinoma (one woman) were investigated. The average age of the patients was 44 and the clinical manifestation were lumbago, melena and fatigue. Two cases were Borrmann III, and other were Borrmann IV, IIc and IIc advanced, respectively. Three were signet-ring cell carcinoma and the other two were moderately differentiated and well-differentiated adenocarcinoma, respectively. All patients showed leukoerythroblastosis. Bone marrow specimens revealed myelofibrosis in three cases, while adenocarcinoma cells were also found in three. MHA or DIC was found in three patients, all of whom died of bleeding tendency. Mean survival time was 2.6 months. Thus, bone marrow carcinomatosis proved to be very severe.
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PMID:[Clinicopathological studies on disseminated carcinomatosis of the bone marrow occurring through metastasis of gastric carcinoma]. 299 95

A case of advanced gastric cancer associated with metastatic carcinomatosis of the bone marrow, microangiopathic hemolytic anemia (MAHA) and disseminated intravascular coagulation (DIC) was reported. A 71-year-old woman complained of lumbago and general fatigue. At the time of admission, besides anemia, jaundice and a tendency to bleeding, the laboratory data showed, hyperbilirubinemia, elevated FDP and hemolytic anemia with fragmented red cells. The bone marrow was infiltrated by carcinoma, and an upper GI series examination showed Borrmann II type gastric cancer on the greater curvature of the antrum. After remission of both MAHA and DIC by mitomycin C, neothramycin and FOY, the patient successfully underwent subtotal gastrectomy. However, she died of cerebral hemorrhage on the 96th postoperative day.
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PMID:[Microangiopathic hemolytic anemia associated with gastric cancer]. 309 84

The effect of a "pure" cyclic flexion bending moment on the three-dimensional load-displacement behavior of fresh ligamentous lumbar spine was investigated. The load-displacement behavior, for 11 L1-sacrum specimens, pre- and post-cyclic fatigue bending tests were quantified using a Selspot II system. A special fixture was designed to mount the specimen within the MTS system to administer "pure" cyclic flexion bending, under displacement control, for 5 hours. The testing was accomplished in a 100% humidity chamber at 0.5 Hz. The maximum cyclic bending moment, based on the literature dealing with loads experienced by the spine during activities involving lifting, was set at 3.0 Nm. An increase in motion of the order of 10% in the extension loading mode was observed. The increase in motion in other loading modes was not significant. In the extension loading mode, the increase in the anteroposterior displacement (retrodisplacement) in general was higher than the corresponding rotation component. The results suggest that the bending moment of low magnitude, usually experienced by the spine during activities of daily living, alone may not trigger the mechanical failure processes in the disc. The presence of high axial compressive loads on the disc seems to be the main contributing factor in this process. The presence of bending moments and axial twist along with axial compressive load may accelerate the unstable processes leading to low back pain.
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PMID:Response of the ligamentous lumbar spine to cyclic bending loads. 338 15

A clinical Phase I study of recombinant human interferon alpha A (Ro 22-8181) was performed in patients with malignant tumors; twenty of them received an American product and seven others a domestic product. Both products were administered in single intramuscularly injected doses of 18, 36, 50, 75 and 100 X 10(6)U. Main side effects included fever and influenza-like symptoms (headache, chill/shivering, general fatigue, lumbago), and digestive symptoms (anorexia, nausea/vomiting). Numbness of fingers or limbs and somnolence were also observed in higher dose groups, but these symptoms all disappeared on the day of administration or by the 3rd day after administration. Abnormal laboratory findings included leukopenia, granulocytopenia, lymphocytopenia, thrombocytopenia and increased GOT/GPT/LDH, but these returned to normal by the 10th day after administration. The peak blood concentration was correlated with the dose, falling to the base line 72 hr after administration. The American product and the domestic product were nearly comparable in the type and incidence of their side effects, and also produced generally comparable blood concentrations. Furthermore, increased anti-IFN-alpha antibody titer was not observed in any of the patients; and the Prick Test proved negative in all of them. No significant changes were observed in any immunological parameters, either.
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PMID:[Phase I study of recombinant human interferon alpha A (Ro 22-8181) in patients with malignant tumors]. 400 81

Twenty-eight outpatients with chronic severe lumbar pain participated in a double-blind comparative trial on the clinical efficacy of orally administered piroxicam and indomethacin. Half of the patients received indomethacin, 25 mg t.i.d.; the other half received piroxicam 20 mg in the morning and a placebo at lunchtime and before dinner for six weeks. The patients were examined four times at two-week intervals for their capability to do daily tasks and for total lumbar mobility, forward bending, raising of both legs straight and the subjective assessment of pain. Side effects were recorded on a questionnaire and with laboratory tests. The overall results of both groups were similar. Thus, piroxicam, 20 mg daily, matches indomethacin, 25 mg t.i.d., in the treatment of low back pain. The side effects were slight. Treatment with indomethacin was stopped in one case (erythema and conjunctivitis). In the piroxicam group diarrhea, constipation, and pain in the tongue were reported, whereas in the indomethacin group gastrointestinal irritation and tiredness were typical symptoms.
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PMID:Double-blind parallel study of piroxicam versus indomethacin in the treatment of low back pain. 623 38

Farming by means of greenhouses has spread in different parts of Japan during the past 20 years. Low back pain, an important health problem for farmers, affects those working inside a greenhouse as a result of their taking up particular postures. In order to analyze ergonomic problems of greenhouse farming relevant to low back pain, localized fatigue complaints and parts of the body where fatigue was felt during fruit picking were studied among 49 female farmers engaged in greenhouse strawberry culture and 53 female farmers engaged in greenhouse eggplant culture. Furthermore, the bowing posture for strawberry picking was compared with that of eggplant picking using newly devised posture-pattern recording equipment. More than 50% of strawberry or eggplant farmers complained of fatigue in the lower back and shoulders. The prevalence of low back pain was significantly higher among strawberry farmers than among eggplant farmers, probably due to the deep bowing posture of the farmer during picking work. The new posture-pattern recording equipment proved useful for investigating changes of work postures.
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PMID:Low back pain related to bowing posture of greenhouse farmers. 646 Aug 3


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