Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this study is to identify those individuals at risk who have weak trunk muscles and are prone to back pain. The overall thrust of this research is to develop a quantitative method to assess dynamic strength of the trunk muscles. Two unique isokinetic strength testing units in sitting and standing postures have been designed. Three groups of volunteers were tested at different times and places. Quantitative measurements of the maximum strength, fatigue behavior of the abdominal and paraspinal muscles, maximum strength in different age groups and the role of the iliopsoas muscle have been performed. The study shows that women have lower maximum strength but equal or better fatigue endurance than men. There is a significant change in maximum strength with age. The maximum abdominal strength change with age showed a bimodal distribution. The iliopsoas muscle approximately doubled the maximum back strength in flexion. The test in the sitting posture was tolerated better than the test in the standing posture. Isokinetic back strength testing in the sitting posture was found to be effective and safe.
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PMID:Isokinetic evaluation of trunk muscles. 623 11

Recombinant interferon-gamma was given to patients with tumours by a six-hour intravenous infusion using a portable mini-pump, to assess the side-effects of the drug. At present, 11 patients have been treated; 2 adenocarcinoma of the ovary, 3 squamous carcinoma of the bronchus, 1 adenocarcinoma of the breast, 1 adenocarcinoma of the stomach, 1 Hodgkin's lymphoma, 1 case of two primaries, adenocarcinoma of the breast and ovary, and 1 adenocarcinoma of unknown origin. Two patients received 1 X 10(6) units/m2/infusion, four received 3 X 10(6) U/m2/inf., three received 6 X 10(6) U/m2/inf. and two received 9 X 10(6) U/m2/inf. Two further dose levels will be used in the future; 27 and 51 X 10(6) U/m2/inf. Three 6-hour infusions a week were given for a four week period. The major side-effects of gamma-interferon were dose-related pyrexia with rigors to which there was no tachyphylaxis, acute and chronic tiredness, nausea with or without vomiting, headache, backache and myalgia. There was also a dose-dependent immediate but mild and transient decrease in the total white cell count. All effects have been transient, and none have been severe. We have also noticed that intravenous infusions by mini-pumps are tolerated far better by the patients than conventional drip systems, and we feel mini-pumps are the ideal way to give intravenous infusions.
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PMID:A phase 1 study of recombinant interferon-gamma given intravenously by portable mini-pump: a preliminary report. 624 30

Pain in the back and lower limbs due to lumbar disorders has a multifactorial etiology, and there is no clear relationship between the morbid pathological change observed and the symptoms experienced. Of the precipitating factors, unaccustomed heavy work, postural fatigue, and injury are common. "Back injury," however, embodies a variety of phenomena, few of which can readily be distinguished either in national statistical data or in previous epidemiologic studies. Thus the causal relationship between back pain and work is far from clear, a difficulty compounded by the prevalence of back symptoms in all groups of the population. There are few epidemiologically established methods for identifying people who are susceptible to a first attack of back pain, though, once back pain has been reported, recurrence may be predicted. Selection of the preventive approach depends on reliable information about the prevalence of back pain/discomfort, the back injury rate, sickness absence, etc; about accidents, work stoppages, job turnover, or any other pointers to the design of the workplace or work practices; and about the resulting losses of productivity and the costs of the remedy. Though the decisions are up to management, the quality of the information required is mainly an occupational health responsibility.
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PMID:Causes, prediction and prevention of back pain at work. 624 75

The relationship between symptoms reported during the first two cycles of oral contraceptive use and subsequent discontinuation was studied using data from a comparative clinical trial of two oral contraceptives (standard dose and low dose) in Sri Lanka. Among 24 symptoms considered, the most commonly reported were headache, nausea, irritability, dizziness, tiredness, intermenstrual spotting/bleeding, backache, abdominal pain, vomiting, and hair loss. Headache, nausea, vomiting, and dizziness were closely associated with each other and strongly predictive of discontinuation for both drugs. No other symptoms were consistently associated with each other or with subsequent discontinuation. Intermenstrual spotting/bleeding was associated with later discontinuation of the standard dose preparation, but not the lower dose preparation.
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PMID:Early symptoms and discontinuation among users of oral contraceptives in Sri Lanka. 639 60

Sexuality was investigated in 35 males and 25 females with chronic back pain. Prior to onset of pain orgasmic dysfunction was common in 60 per cent of the females with relatively lower level of sexual frustration. Markedly less sexual dysfunction characterized the males. With back pain sexual dysfunction increased in both sexes. Frequency of coitus was reduced in half the subjects and about 50 per cent also had altered coital positions. Fatigue and pain were common and sexual enjoyment was reduced for most subjects. In many females back pain may serve to legalize previously latent sexual dysfunction. However, for both sexes back pain per se causes sexual maladaptation. Therefore, sexual counselling should be part of the rehabilitation of the back pain sufferer.
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PMID:Chronic back pain and sexuality. 645 10

Spondylolysis occurring after a spinal fusion is considered to result from operative damage to the pars interarticularis on both sides. Fourteen cases are reported, and compared with the 23 cases which have previously been published. The defects are usually recognised within five years of fusion, and usually occur immediately above the fusion mass. Other contributory causes may be: fatigue fracture from concentration of stress; damage and altered function of the posterior ligament complex; and degenerative disc disease immediately above or below the fusion. Fusion technique is critical, since virtually all cases occurred after posterior interlaminar fusions. This complication is easily overlooked in patients with recurrent back pain after an originally successful posterior spinal fusion.
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PMID:Acquired spondylolysis after spinal fusion. 650 68

Stress Inventory-6, a 72-item self-report questionnaire designed to tap 18 factors of physical stress reactions, was subjected to factor analysis. The instrument was given to 474 students (254 females, 206 males, and 14 who failed to indicate their gender). The final factor solution identified 16 first-order and 4 second-order factors. The first-order solution replicated most of the factors identified in a previous study and defined factors in terms of organ system, muscle group, and simple content. In the second-order solution, Factors I, III, and IV include symptoms that are immediate and direct, appear to be related to arousal of the somatic and sympathetic nervous system, and are marked prominently by cardiorespiratory activity. In contrast, Factor II includes symptoms that are indirect and often delayed consequences of sustained arousal (Fatigue and Lack of Energy, Headaches, Backaches, etc.). A major distinction can be made between stress arousal Factors I and III. Factor III appears to be a simple "fight or flight" arousal pattern characterized by fairly direct manifestations of striated muscle tension as well as cardiorespiratory activity. In contrast, Factor I is a complex arousal pattern characterized by diffuse autonomic arousal, self-directed attention, and possibly low self-esteem. The results of this study draw into question the extent to which popular stress inventories tap a representative sample of stress symptoms. Clinical implications are discussed.
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PMID:Self-reported physical stress reactions: first- and second-order factors. 650 11

double-blind cross-over study with Org OD 14 was done in 35 post-menopausal patients aged 48-69 years who had hot flushes and other associated symptoms. Patients were randomly allocated to Org OD 14 or to placebo as first treatment. Each period of treatment lasted for 6 weeks and there were no intervals between treatments. Tablets containing 2.5 mg of Org OD 14 or placebo tablets of identical appearance were supplied. Patients took one Org OD 14 tablet or one placebo tablet per day. Data on the following variables were obtained and analyzed statistically: hot flushes, sweating, dizziness, palpitation, tiredness, headache, insomnia, irritability, breathlessness, backache, loss of libido, and mood. Assessment was daily in the case of hot flushes and weekly for the other variables. Org OD 14 was statistically significantly more effective in controlling hot flushes, sweating and headache and tended to be better than the placebo tablets for the other variables.
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PMID:Double-blind cross-over study with Org OD 14 and placebo in postmenopausal patients. 666 Sep 26

The purpose of this study was to determine the prevalence of perimenstrual symptoms (PMS) in a free-living population of US women and to determine if prevalence estimates varied with parity, contraceptive status, characteristics of the menstrual cycle, and selected demographic variables. We identified all households from a census listing for five southeastern city neighborhoods that offered variation in racial composition and socioeconomic status. We ascertained all households in which there was one nonpregnant woman between the ages of 18 and 35 years per household. Of the 241 eligible women, 179 (74 per cent) participated in the study. Trained interviewers administered the Moos Menstrual Distress Questionnaire (MDQ) and other demographic measures to women between March and July 1979. Symptoms with a prevalence greater than 30 per cent included weight gain, headache, skin disorders, cramps, anxiety, backache, fatigue, painful breasts, irritability, mood swings, depression, or tension. Only 2 to 8 per cent of women found most of these severe or disabling. The exceptions were severe cramps reported by 17 per cent of women and severe premenstrual and menstrual irritability by 12 per cent. Cramps, backaches, fatigue, and tension were most prevalent during the menstruum; weight gain, skin disorders, painful breasts, swelling, irritability, mood swings, and depression were more prevalent in the premenstruum. Parity, oral contraceptive use, age, employment, education, and income were negatively associated with selected PMS. Use of an IUD, having long menstrual cycles, long menstrual flow, or heavy menstrual flow, and being able to predict the next period were positively associated with selected PMS. Race had both positive and negative effects on PMS.
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PMID:Prevalene of perimenstrual symptoms. 688 17

Recent research findings contradict the notion that premenstrual and menstrual symptoms constitute two mutually exclusive categories of perimenstrual distress. The purposes of this study were to describe the prevalence of distress associated with menstruation in a community population and to determine whether perimenstrual distress could be regarded as a single construct. Nonpregnant women (N = 193) between 18 and 35 were selected from five neighborhoods in a southeastern city in a way that allowed for variability in race and income. The women were interviewed in their homes and 179 were asked to complete the Moos Menstrual Distress Questionnaire (MDQ). At least 30% of the women reported weight gain, skin disorders, backache, painful or tender breasts, irritability, depression, headache, cramps, fatigue, swelling, mood swings or tension in the perimenstruum. Cycle phase differences were not found for 31 MDQ symptoms, but were found for: weight gain, crying, lowered school or work performance, taking naps, headache, skin disorders, cramps, anxiety, backache, fatigue, painful or tender breasts, swelling, irritability, mood swings, depression, and tension. Although there were significant differences between the premenstrual and menstrual phases for certain symptoms, the magnitudes of the mean differences were small (less than .3) except for cramps, weight gain, and fatigue. Furthermore, premenstrual and menstrual reports of the same symptoms were highly correlated. Thus, it appears reasonable to study perimenstrual distress as a single construct.
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PMID:Toward a construct of perimenstrual distress. 692 41


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