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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hypermobility denotes an increased range of joint movements and is the result of ligamentous and joint capsule laxity. Benign joint hypermobility syndrome is hypermobility associated with symptoms--arthralgia, myalgia, fatigue, anxiety and fibromyalgia. Clinical manifestations of benign joint hypermobility syndrome include almost all organic systems, and reflect the ubiquity of connective tissue in the body. Beighton score help us to diagnoses hypermobility. Hypermobility syndrome is diagnosed using the 1998 "Brighton criteria". The purpose of this case report was to emphasize the importance of recognition hypermobility syndrome because such individuals represent a significant percentage patients who seek help of different specialist and because of the diversity of the clinical presentation very long stay unrecognized (undiagnosed). Hypermobility can be easily detected if you are looking for, but is easily overlooked if you do not think about it.
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PMID:[Benign joint hypermobility syndrome--a case report: unrecognized or undiagnosed condition?]. 2094 40

Fibromyalgia syndrome (FMS) is a common and intriguing condition, manifest by chronic pain and fatigue. Although the pathogenesis of FMS is not yet completely understood, predicting the future development of FMS and chronic pain is a major challenge with great potential advantages, both from an individual as well as an epidemiological standpoint. Current knowledge indicates a genetic underpinning for FMS, and as increasing data are accumulated regarding the genetics involved, the prospect of utilizing these data for prediction becomes ever more attractive. The co-existence of FMS with multiple other functional disorders indicates that the clinical identification of such symptom constellations in a patient can alert the physician to the future development of FMS. Hypermobility syndrome is another clinical (as well as genetic) phenotype that has emerged as a risk factor for the development of FMS. Stressful events, including early life trauma, are also harbingers of the future development of FMS. Functional neuroimaging may help to elucidate the neural processes involved in central sensitization, and may ultimately also evolve into markers of predictive value. Last but not least, obesity and disturbed sleep are clinical (inter-related) features relevant for this spectrum. Future efforts will aim at integrating genetic, clinical and physiological data in the prediction of FMS and chronic pain.
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PMID:Predicting fibromyalgia, a narrative review: are we better than fools and children? 2461 70