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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Functional disorders of the circulation imply an inadequate circulatory response to repeated, in particular mental strain, associated with typical complaints and manifestations. Instead of the formerly used term of neurocirculatory asthenia nowadays neurotic conditions with manifestations in the circulation are described more frequently as hyperventilation syndrome, syndrome of chronic fatigue or panic anxiety syndrome. The paper deals with the pathogenesis, diagnosis, prognosis and therapy where a talk with the patient, elucidating the relationship between the stressing situation and circulatory manifestations is most important.
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PMID:[Disorders of circulation regulation and heart disease]. 152 56

Fatigue is a frequent complaint from patients suffering from the hyperventilation syndrome. Fatigue was quantified in terms of the endurance time that a certain force can be generated in a sustained handgrip contraction, and in terms of the time course of changes in certain parameters of the EMG-power spectrum of the contracting muscles. This was done in a group of 25 normal subjects and a group of 30 patients suffering from the hyperventilation syndrome. No difference in endurance times was found. The EMG-fatiguability in the hyperventilation group developed even slower than in the normal group. In three normals the fatigue parameters were also measured in three conditions of normo-, hypo-, and hyper-capnia. No intraindividual correlations were found between fatigue parameters and CO2-levels. Neither were such correlations found between individuals in the hyperventilation group and the normal group. It is concluded that the subjective feelings of fatigue in the hyperventilation patients cannot be corroborated by the objective measurements used in this study. Thus their fatigue is not of a peripheral type. The levels of CO2 do not have an effect on objectively measured fatigue parameters. The hypothesis that lactate accumulation in contracting muscles mediates EMG-fatiguability, cannot explain the present results, and therefore is not supported by results from this study.
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PMID:Hyperventilation syndrome and muscle fatigue. 340 98

It has been difficult to confirm that a given building is responsible for allergic symptomatology, exacerbation of asthma, or immunological dysfunction. In fact, in most studies, few objective immunological parameters have been studied and only rarely has there been any quantitation of IgE or secondary mediators. Furthermore, although many studies deal with rhinitis or respiratory tract irritation, there is a misconception that all such symptoms are allergic in nature, and studies attempting to prove that allergies are caused by buildings frequently neglect to prove that these are indeed true allergic responses. In addition, many of the symptoms that people attribute to sick building syndrome (SBS) or building-related illness, such as headaches, dizziness, fatigue, nausea, cough, and eye irritation, are subjective, and studies often fail to take into account other possible causes that may be inherent in the subjects, such as sinusitis, hyperventilation syndrome, or psychosomatic illness. Unfortunately, most clinical studies on SBS pay little attention to the preexisting conditions that a subject may have and discount the possibility that the inciting agent does not cause symptoms, but merely exacerbates a preexisting condition. Moreover, they offer no information about the nature of the mechanisms of action or pathophysiological relationships. Clearly, further studies are necessary to further explain the complexity of complaints that currently exist. Indeed, SBS might properly be paraphrased as "what is it?--if it is!"
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PMID:The sick building syndrome. I. Definition and epidemiological considerations. 833 Oct 40