Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

When treating patients with epilepsy, dealing with seizure-precipitating factors is a partly neglected and underestimated supplement to more traditional therapies. The aim of this study was to investigate the incidence of seizure precipitants in a large epilepsy population and to determine which precipitants patients most often reported. Study participants included twins and their family members ascertained from the Norwegian Twin Panel (NTP), the Danish Twin Registry (DTR), and the Mid-Atlantic Twin Registry (MATR). One thousand six hundred seventy-seven patients with epilepsy were identified and were asked about seizure precipitants using a closed-ended questionnaire. Fifty-three percent reported at least one seizure-precipitating factor, while 30% claimed to have experienced two or more such factors. Emotional stress, sleep deprivation, and tiredness were the three most frequently reported precipitants. Patients with generalized seizures seemed to be more sensitive to sleep deprivation and flickering light than those with partial seizures, while women with partial seizures appeared to be more prone to seizures during menstruation than women with generalized seizures. Knowledge of seizure precipitants has practical implications, not only in patient treatment and counseling, but also for diagnosis, in that it may be helpful in facilitating the appearance of interictal epileptiform discharges in EEG and ictal EEG recordings.
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PMID:Which seizure-precipitating factors do patients with epilepsy most frequently report? 1565 38

Disease and cancer treatment-related side effects such as decreased energy level, muscle weakness, and declines in functional status and body mass have been well documented. There is evidence that exercise, such as low intensity aerobics walking, Tai Chi, or cycling, results in an overall decrease in fatigue levels over the course of cancer treatment. Additionally, there is evidence that regular physical activity or exercise can decrease emotional stress, blood pressure, the duration of neutropenia, thrombocytopenia, and pain. Exercise also has been shown to increase quality of life and improve the maximal oxygen uptake during exertion, sleep patterns, and cognition. However, the majority of studies of exercise and cancer have been conducted with women with early stage breast cancer, limiting the generalizability of these studies to other cancer populations. The purpose of this systematic review is to provide a synthesis of the extant research evidence about th e benefits of exercise related to cancer recovery.
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PMID:Exercise and cancer recovery. 1597 80

Orofacial herpes is a common benign disease suspected to significantly impact the quality of life (QOL) of affected subjects. The objective of this population-based study was to evaluate the annual prevalence of orofacial herpes in France, its epidemiology, and its impact on QOL. Face-to-face home interviews were conducted among a random sample of 10,263 adults. A screening questionnaire identified subjects with a history of orofacial herpes (or cold sore) during the past 12 months; then, subjects with herpes completed another questionnaire to further describe their disorder and its management, and the SF-36 questionnaire to assess their QOL. The annual prevalence of orofacial herpes was 14.8% (95% confidence interval 14.03; 15.47); it was significantly higher in women than in men (P < .001) and decreased with age (P < .001). Among subjects with herpes, only 23% were aware of their disease. Tiredness and emotional stress were the main triggering events. There was no detectable difference between subjects with herpes and controls on SF-36 scores; however, when compared with subjects with 1 to 5 episodes per year, subjects with 6 or more episodes per year had significantly lower QOL scores.
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PMID:A survey on the prevalence of orofacial herpes in France: the INSTANT Study. 1684 3

In this study, we examined the effect of rapidly increased training volume and intensity on hormonal responses (salivary cortisol [C] and urinary dehydroepiandrosterone sulphate [DHEA-S]) and recovery-stress state perceived by 12 female cyclists. Over the 4-day experimental period, there was an average increase in training load of approximately 122% compared with that during the previous 12 days. Scores on subscales of the Recovery Stress Questionnaire for Athletes increased for the somatic component of stress (Fatigue, Emotional Stress and Social Stress; P<0.05) and decreased the factor indicating recovery (General Well Being; P<0.05) after the heavy training period. The training programme increased resting concentrations of salivary cortisol (P<0.05) and decreased the DHEA-S/C ratio (P<0.05). The increase in training load of cyclists was correlated with this hormonal ratio (r=-0.48, P<0.05). Changes in resting cortisol concentration as a result of heavy training stress were positively related to the change in Physical Complaints (r=0.69, P<0.01). Negative relationships were also found between changes in the DHEA-S/C ratio and changes in the somatic component of stress. The present results suggest that there is a dose-response relationship between increased training load, resting DHEA-S/C ratio and subjective assessment of stress and recovery, implying that this ratio could be used as an indicator of training status in female athletes.
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PMID:Relationships among training stress, mood and dehydroepiandrosterone sulphate/cortisol ratio in female cyclists. 1710 32

The aim of the trial was to study factors predisposing to acute urine retention (AUR) in patients with prostatic adenoma (PA). The trial was made in Perm Center for Urgent Urological Care. This allowed registration and analysis of all cases of AUR in the city with population of 1 million people. For 11 years there were 1504 episodes of AUR in 1130 PA patients. One AUR episode was registered in 888 (78.6%) patients, two to four--in 242. Questioning of the patients, the disease histories analysis provided information on the factors predisposing to AUR. The following factors provoked AUR: alcohol intake (25.9%), water loading (11.5%), medication (atropin, belladonna, efedrin, aminasin, tizercin, phenobarbital, imisin, promedol, lazix, etc.; 11.4%), acute inflammation of the adenomatous nodes (7.4%), cold (6.7%), spicy food (5.5%), flebitis of the hemorrhoidal veins (5.5%), fatigue (5.1%), emotional stress (3.9%), forced urine retention (3.1%), bed rest (2.8%), sexual excesses (2%), surgical interventions (2%), etc. AUR occurred more often in the morning (at 4 to 8 o'clock a.m.), in the holidays and after them (92.5% of these patients took alcohol), on days with acute fluctuations of atmospheric pressure, temperature, air humidity. A complex of meteoprophylaxis of AUR is proposed.
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PMID:[Factors predisposing to acute urine retention in patients with prostatic adenoma]. 1758 Mar 84

During Ramadan, the ninth month of the Islamic lunar calendar, adult Muslims are required to refrain from taking any food, beverages, or oral drugs, as well as from sexual intercourse between dawn and sunset. In this study, we aimed at discovering alterations in drug regimens and the seizure frequency of epileptic patients during Ramadan (15 October 2004-13 November 2004). In the 3 months following Ramadan in the year 2004, 114 patients with epilepsy who were fasting during Ramadan were examined at our Epilepsy Department. Of the 114 patients who were included in the study, 38 patients had seizures and one of these patients developed status epilepticus during Ramadan. When the seizure frequency of these patients during Ramadan was compared to that in the last 1 year and last 3 months period just prior to Ramadan, a statistically significant increase was observed (p<0.001). Moreover, there was an important increase in the risk of having seizures in the patients who changed their drug regimens compared with those who did not (p<0.05). In the patients who received monotherapy or polytherapy, no difference in the frequency of seizures during Ramadan was seen (p>0.05). During Ramadan, an increase in the seizure frequency of patients with epilepsy was observed. The most important reason for this situation was the alteration in the pharmacokinetics and pharmacodynamics of drugs, and consequently, in their efficacy. We believe that in the patients who received monotherapy and who did not change their drug regimes, the increase in seizure frequency may have been related to the changes in their daily rhythms, emotional stress, tiredness and their day-long fasting.
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PMID:Does the seizure frequency increase in Ramadan? 1846 59

Episodic ataxia type 1 (EA1) is a rare human neurological syndrome characterized by continuous myokymia and attacks of generalized ataxia that can be triggered by abrupt movements, emotional stress and fatigue. An Italian family has been identified where related members displayed continuous myokymia, episodes of ataxia, attacks characterized by myokymia only, and neuromyotonia. A novel missense mutation (F414C), in the C-terminal region of the K(+) channel Kv1.1, was identified in the affected individuals. The mutant homotetrameric channels were non-functional in Xenopus laevis oocytes. In addition, heteromeric channels resulting from the co-expression of wild-type Kv1.1 and Kv1.1(F414C), or wild-type Kv1.2 and Kv1.1(F414C) subunits displayed reduced current amplitudes and altered gating properties. This indicates that the pathogenic effect of this KCNA1 mutation is likely to be related to the defective functional properties we have identified.
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PMID:A novel KCNA1 mutation identified in an Italian family affected by episodic ataxia type 1. 1892 84

Obesity, excessive daytime sleepiness (EDS), and self-reported short sleep duration appear to be on the rise, while there is evidence that obesity and these sleep disorders are strongly connected. In this paper, we review data that challenge the common belief that the sleep apnoea and sleep loss, frequently associated with obesity, are the primary determinants of obesity-related objective daytime sleepiness and subjective fatigue (tiredness without increased sleep propensity). Specifically, obesity is associated with objective and subjective EDS regardless of the presence of sleep apnoea. The association between obesity and EDS was confirmed in recent studies of large random samples of the general population or clinical samples, which showed that the primary determinants of subjective EDS were depression, metabolic disturbances, i.e. obesity/diabetes and insulin resistance, and lack of physical activity, and, secondarily, sleep apnoea or sleep loss. Paradoxically, within the obese, with or without sleep apnoea, those who slept objectively better at night are sleepier (objectively) during the day than those who slept worse. The distinguishing factor between those that slept better vs. those that slept worse appears to be level of emotional stress. Furthermore, many studies reported that obesity is associated with self-reported short sleep duration; however, it appears that short sleep duration is a marker of emotional stress rather than a reflection of true sleep loss. Based on these data, we propose that obesity-related deeper sleep and objective EDS are primarily related to metabolic disturbances, whereas obesity-related poorer sleep and subjective fatigue appear to be the result of psychological distress. Furthermore, based on data from studies in normal controls and patients with sleep disorders, it appears that the interaction of the hypothalamic-pituitary-adrenal (HPA) axis and pro-inflammatory cytokines determines the level of sleep/arousal within the 24-hour cycle, i.e. "eucortisolemia" or "hypocortisolemia" plus hypercytokinemia is associated with high sleep efficiency and objective sleepiness, whereas "hypercortisolemia" plus hypercytokinemia is associated with low sleep efficiency and fatigue. In conclusion, we propose that the above-reviewed data provide the basis for a meaningful phenotypic and pathophysiologic sub-typing of obesity. One subtype is associated with emotional distress, poor sleep, fatigue, HPA axis "hyperactivity," and hypercytokinemia while the other is associated with non-distress, better sleep but more sleepiness, HPA axis "normo or hypoactivity," and hypercytokinemia. This proposed sub-typing may lead to novel, preventive and therapeutic strategies for obesity and its associated sleep disturbances.
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PMID:Obesity and sleep disturbances: meaningful sub-typing of obesity. 1894 83

Patients with chronic fatigue syndrome (CFS) frequently associate the disease onset with a period of high physical and/or emotional stress. Alterations in hypothalamic-pituitary adrenal axis (HPA) function have been demonstrated. Although Cortisol production in patients with CFS has proven to be low, Dehydroepiandrosterone (DHEA) production has not been measured. DHEA output may be altered in this population. The purpose of this uncontrolled, prospective, 6 month study of 23 white women, ages 35-55 was to identify CFS patients with suboptimal serum levels of DHEA-sulphate (DHEA-S), defined as DHEA-S <2.0 microg/mL, and to treat those patients with oral DHEA. DHEA-S levels were re-measured after 4-6 weeks of oral DHEA therapy (25 mg). If DHEA-S remained <2.0 microg/ mL, or if no clinical response was achieved after 4-6 weeks of therapy, then an increased dose of DHEA was given. Physical and psychological impairment and disability status were measured by the MHAQII before DHEA intervention and at 3-month intervals. Of initially screened patients with CFS, 76% (116 of 153) were ages 35-55, and 89% (103 of 116) had suboptimal (<2.0 microg/mL) production of DHEA-S.Supplementation with DHEA to CFS patients lead to a significant reduction in the symptoms of CFS: pain (improved by 18%, p = 0.035), fatigue (decreased by 21%, p = 0.009)), activities of daily living (improved by 8.5%, p = 0.058), helplessness (decreased by 11%, p = 0.015), anxiety (decreased by 35%, p < 0.01), thinking (improved by 26%, p < 0.01), memory (improved by 17%, p < 0.05), and sexual problems (improved by 22%, p = 0.06) over the period of the trial. Further study is necessary to determine the safety and efficacy of supplementation of DHEA to this population in a controlled setting.
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PMID:A pilot study employing Dehydroepiandrosterone (DHEA) in the treatment of chronic fatigue syndrome. 1907 57

The dynamics of structural and ultrastructural changes of dorsomedial the hypothalamic nuclei in rats with chronic emotional stress within 10 months has been studied. It was found that stress loading increases the signs of damages of the nervous tissue. These signs were manifested as disorders of the structural organization of synaptic terminals and synaptic vesicles, and in the change of relation of types of synaptic contacts. Disorders in mitochondria structures, appearance of multivesicle little bodies and other osmiophil membrane structures of various types and edema development indicate on progressing destructive processes in the nervous tissue. The structures of the hypothalamus area underwent damages of different degree, thus causing a mosaic character of changes. Along with the adaptive processes we noticed rough destructive damages of structures up to the death of dendrites, pointing to systemic and irreversible character of changes in the brain tissue. Such changes can reflect adaptation-disadaptation changes in the tissue of the hypothalamic area under a long-term stress exposure and signs of decompensation or prepathological state of overstrain and to be morphofunctional basis of chronic fatigue.
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PMID:[Utrastructural organization of the dorsomedial hypothalamic nuclei in rats with experimental chronic stress]. 1982 36


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