Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A menstrual symptom questionnaire was used to assess the incidence of premenstrual tension (PMT) in 1,395 regularly menstruating women not on hormonal contraceptives or any other hormonal therapy during routine visits to a gynecologic clinic. Nineteen symptoms were divided into four PMT subgroups: PMT-A (anxiety, irritability, mood swings, nervous tension), PMT-H (weight gain, swelling of extremities, breast tenderness, abdominal bloating), PMT-C (headache, craving for sweets, increased appetite, heart pounding, fatigue and dizziness or fainting) and PMT-D (depression, forgetfulness, crying, confusion, insomnia). The ages of the patients ranged from 13 to 54 years, with a mean +/- S.D. of 32 +/- 8.5 years. Using strict criteria for PMT, 702 patients scored positive for at least one subgroup of PMT, giving an incidence of 50%. When the patients were divided into five-year age groups, a peak incidence of 60% was observed in the third decade of life. The most common PMT subgroups were PMT-A and PMT-H, occurring either alone or in combination. The least common subgroup was PMT-D, occurring in only 12 patients and by itself. The mean cycle length in pure PMT-D patients was significantly shorter (p less than 0.05) than in patients without PMT.
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PMID:The incidence of premenstrual tension in a gynecologic clinic. 689 20

Recent research findings contradict the notion that premenstrual and menstrual symptoms constitute two mutually exclusive categories of perimenstrual distress. The purposes of this study were to describe the prevalence of distress associated with menstruation in a community population and to determine whether perimenstrual distress could be regarded as a single construct. Nonpregnant women (N = 193) between 18 and 35 were selected from five neighborhoods in a southeastern city in a way that allowed for variability in race and income. The women were interviewed in their homes and 179 were asked to complete the Moos Menstrual Distress Questionnaire (MDQ). At least 30% of the women reported weight gain, skin disorders, backache, painful or tender breasts, irritability, depression, headache, cramps, fatigue, swelling, mood swings or tension in the perimenstruum. Cycle phase differences were not found for 31 MDQ symptoms, but were found for: weight gain, crying, lowered school or work performance, taking naps, headache, skin disorders, cramps, anxiety, backache, fatigue, painful or tender breasts, swelling, irritability, mood swings, depression, and tension. Although there were significant differences between the premenstrual and menstrual phases for certain symptoms, the magnitudes of the mean differences were small (less than .3) except for cramps, weight gain, and fatigue. Furthermore, premenstrual and menstrual reports of the same symptoms were highly correlated. Thus, it appears reasonable to study perimenstrual distress as a single construct.
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PMID:Toward a construct of perimenstrual distress. 692 41

In the introduction the concept of health is discussed. The author emphasizes that the concept of health is often used in a biased and uncritical manner in discussions on the value of physical activity in relation to health. The practice of physical activity should be seen in relation to a more holistic concept of health, defined as a human being's total ability to function. Results are then presented from a number of investigations, of which the majority indicate a positive relation between physical activity and a reduction in the following indices of mental health: anxiety, depression, nervousness, sleep problems emotional instability and general fatigue. This particularly applies however to persons who at the onset are in especially poor physical and mental condition. In conclusion the results of a nationwide investigation conducted by the author are discussed. The indices of mental health used were sleep problems, nervous disorders and overexertion. Physically active persons over 50 years old have better mental health than physically passive ones. However a corresponding difference was not found in younger age groups. The article attempts to show what we "know" about the relationship between the practice of physical activity and some aspects of mental health.
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PMID:Leisure time, physical activity and some indices of mental health. 695 34

The clinical efficacy of tolfenamic acid and mefenamic acid in the treatment of primary dysmenorrhoea was studied in a prospective, controlled, double-blind, cross-over study comprising 73 patients aged 13-39 with an average body weight of 56 kilos. The patients were randomized to receive either tolfenamic acid (200 mg t.i.d.) or mefenamic acid (500 mg t.i.d.) for 3 days, during 3 consecutive menstrual cycles each, in a sequential design A-B or B-A. At the beginning and at the end of each treatment period, 13 dysmenorrhoeic symptoms were evaluated on a visual analogue scale (lower back pain, interference with daily activities, nausea, vomiting, diarrhoea, headache, dizziness, fatigue, sweating, chills, hot flashes, depressant states, and mood swings). The data were analyzed by using two statistical models. The first one, for the 73 patients, by making paired comparisons regardless of treatment sequence. With respect to the initial values, the results showed that both drugs were statistically significant (P < 0.05) in reducing the intensity of the evaluated symptoms. When comparing both treatments, tolfenamic acid showed a significant difference as to interference with daily activities (P < 0.025) and hot flashes (P < 0.005). In the result analysis with the second model, the groups were divided according to the first assigned treatment and paired comparisons were made. It was observed that the group receiving tolfenamic acid in the last sequence reached a higher level of response and statistical significance was demonstrated in 8 of 13 evaluated symptoms.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Tolfenamic acid and mefenamic acid in the treatment of primary dysmenorrhoea. 781 93

A 39-year old woman presented with hallucinatory paranoid state, particularly with erotomania, around September, 1988 (at the age of 39), and was hospitalized in a mental hospital for 9 days from May 1, 1989, to receive major tranquilizer therapy. At admission, the leukocyte count was 10,400/mm3 showing a mild leukocytosis, and there was temporary adynamia in the upper extremities. Thereafter, mild leukocytosis persisted intermittently. On May 12, 1989, the patient visited the Department of Neuropsychiatry, Kansai Medical University, and clinical examinations revealed mental symptoms including insomnia and erotomania, delusion of reference and auditory hallucination without persecutory taint. She showed clear consciousness and well understanding. Characteristically, her expression and behavior were smooth and emotional communication was available. There were neither alterations in her basic mood, nor flaccid association of idea. No abnormalities were seen in the hair and skin, and buffalo hump was not observed. Blood examination revealed a leukocyte count of 10,700/mm3, suggesting a mild leukocytosis. According to the patient, the menses have been regular. Although major tranquilizer therapy has been maintained, she gradually developed emotional instability, and tended to show fatigue and regressive changes in her personality. She was hospitalized in a mental hospital from October 25, 1989 to July 24, 1991. Since 1990, when she was in the hospital, she gradually developed obesity, hypertension, acne, and diabetes mellitus.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[A case of Cushing's disease: hallucinatory paranoid state preceding physical symptoms]. 793 10

To investigate factorial construct validity of a measurement scale of fatigue symptoms in junior high school students, a questionnaire which consisted of Cumulative Fatigue Symptoms Index (CFSI) and Psychological Condition Test (PCT) was administered on 289 students in Okinawa. Reliability coefficients were 0.607-0.811 for CFSI scales. A principal factor analysis with varimax rotation was applied to CFSI. In boys, 4 factors were extracted; general psychological symptoms, fatigue, emotional instability, and decreased morale and vitality. In girls, 4 factors were extracted; depression and anxiety, decreased morale and vitality, fatigue, and irritability. The same procedure was applied to PCT. In boys, 4 factors were extracted; negative feeling, vigor, inferiority complex, and fatigue. In girls, 4 factors were extracted; negative feeling, anger, vigor, and fatigue. Among factors derived from CFSI and PCT, the fatigue factor of CFSI was correlated with that of PCT. The factors concerning psychological symptoms of CFSI were correlated with those of PCT. However, the vigor factor of PCT was not correlated with any other factors. These results suggest that CFSI in junior high school students had factorial construct validity.
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PMID:[Factorial construct validity of a measurement scale of fatigue in junior high school students]. 826 75

Exposure to a 50/60-Hz electromagnetic field can decrease the nocturnal production of melatonin in rodents. Melatonin is considered to be a marker of circadian rhythms, and abnormalities in its secretion are associated with clinical disorders, including fatigue, sleep disruption, mood swings, impaired performance, and depression, which are consequences of desynchronisation. Interestingly, some epidemiological studies have been reported finding most of these clinical disorders in individuals living or working in an environment exposed to electromagnetic fields. This experiment was designed to look for the possible effects of acute exposure (9 hours) to 50-Hz linearly polarized magnetic fields (10 mu T) on the pineal function. Thirty-two young men (20-30 years old) were divided into two groups (control group, i.e., sham-exposed: 16 subjects; exposed group: 16 subjects). All subjects participated in two 24-hour experiments to evaluate the effects of both continuous and intermittent exposure to linearly polarized magnetic fields. They were synchronized with a diurnal activity from 08:00 to 23:00 and nocturnal rest. The experiment lasted two months (mid-February to mid-April). The subjects were exposed to the magnetic fields (generated by three Helmholtz coils per bed) from 23:00 to 08:00, while lying down. Blood samples were collected during each session at 3-hour intervals from 11:00 to 20:00 and hourly from 22:00 to 08:00. Total urine was collected every 3 hours from 08:00 to 23:00 and once during the night, from 23:00 to 08:00. The levels of serum melatonin and its metabolite in urine (6-sulfatoxymelatonin) in exposed men did not differ significantly from those in control (sham-exposed) subjects. This study shows that nocturnal acute exposure to either continuous or intermittent 50-Hz linearly polarized magnetic fields of 10 mu T does not affect melatonin secretion in humans.
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PMID:Magnetic fields and pineal function in humans: evaluation of nocturnal acute exposure to extremely low frequency magnetic fields on serum melatonin and urinary 6-sulfatoxymelatonin circadian rhythms. 864 83

Emotional instability which might be an early symptom of more severe disorders, is one of the first manifestations of chronic exposure to organic solvents. The present study measures the association between exposure to styrene and mood states of active workers. A total of 128 workers (85% of the total population) from 3 factories where styrene is used, participated on a voluntary basis. They filled out the following self-administered questionnaires: Profile of Mood States (POMS), Psychiatric Symptom Index and Well-being Index. The results indicate a significant relationship between post work-shift urinary mandelic acid (biological indicator of styrene exposure) and the scores obtained on the POMS scales of tension-anxiety (Spearman's rank correlation rho = 0.30; p < 0.01), anger-hostility (rho = 0.29; p < 0.01), fatigue-inertie (rho = 0.34; p < 0.01), and confusion-bewilderment (rho = 0.23; p = 0.04), as well as the Psychological Distress Index (rho = 0.30; p < 0.01). All scores were adjusted for the effects of 4 potentially confounding variables: age, schooling, alcohol and cigarette consumption. These indicators of mood states do not constitute a diagnosis of mental disease but reveal progressive deterioration of well being associated with neurotoxic exposure in the workplace.
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PMID:[Mental health deterioration in workers exposed to styrene]. 885 39

We explored perimenstrual symptoms among 16 Chinese women in an urban area of southeastern China using a retrospective questionnaire, the Menstrual Distress Questionnaire (MDQ), and a prospective daily symptom diary, the Daily Health Diary (DHD), modified for cultural relevance. Mean scores on the DHD were significantly (p < .03) higher during the perimenstrual phase for the symptoms fatigue, increased sensitivity to cold, increased sleeping, abdominal pain/discomfort, painful or tender breasts, and decreased sexual desire. The women who reported higher DHD physical symptom scores prospectively were more likely to recall more severe physical symptoms retrospectively on the MDQ. However, there were remarkable discrepancies between the DHD and MDQ regarding psychoemotional symptoms. By retrospective MDQ, the percentages of women who experienced severe mood swings and irritability ranged from 13% to 25% during the premenstrual and menstrual phases; on the DHDs, however, these emotional symptoms were not statistically associated with the menstrual cycle. The failure of prospective charting to confirm the retrospective reports of cyclic psychoemotional symptoms agrees with findings of studies of U.S. samples. We conclude that perimenstrual distress in Chinese women may be affected by the data collection methods.
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PMID:Perimenstrual symptoms among Chinese women in an urban area of China. 885 18

Disinfectant surveys from responding members of the American Society of Postanesthesia Nurses were divided into two groups based on whether or not they considered themselves to be exposed to disinfectants in their work environment. Their survey responses were then compared with those obtained previously from members of the Society of Gastroenterology Nurses and Associates, Inc., who were regularly exposed to 2% alkaline glutaraldehyde in the work setting. There were significant differences among the groups in the percentage of respondents who reported having headaches, eye irritations, respiratory problems, shortness of breath, rashes, memory loss, mood swings, and fatigue. These findings support the association of these complaints with 2% alkaline glutaraldehyde exposure. In contrast, there were no significant differences among the groups in the percentage of respondents who reported having asthma, rhinitis, chest pain, nausea, diarrhea, muscle/joint pain, visual disturbances, or dermatitis.
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PMID:Society of Gastroenterology Nurses and Associates, Inc. (SGNA) Endoscopic Disinfectant Survey results compared with control group. 902 1


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