Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A discrepancy between complaints of varicose veins of the legs such as stabbing in the legs, pain in the legs, tiredness of the legs, heaviness of the legs, feeling of swelling in the legs and nocturnal cramps in the calves, and anatomical signs of varicose veins in the legs was observed. Therefore these complaints were analyzed in 345 antenatal patients regarding their psychological aspects. No complaints of venous insufficiency were found in 47% of the pregnant women. Of the 53% antenatal patients with complaints, 24% had mild, 18% had moderate and 11% had severe complaints. Antenatal patients with well noticable neurotic personality traits in the MPI had complaints twice as often as women without neurotic traits (p smaller than 0.05). Introverted antenatal patients (according to the MPI) had more venous leg complaints than expected (p smaller than 0.05). Pregnant women with frequent psychosomatic complaints and altered general well being had the highest incidence of varicose veins complaints (p smaller than 0.001) or p smaller than 0.05). In addition to these psychometric data, there was also a correlation of the gynaecological history with complaints of venous insufficiency in the legs during pregnancy. Pregnant women with a very painful menarche had more varicose vein complaints than expected (p smaller than 0.05). The incidence was also higher with a history of abortion (p smaller than 0.05), marked dysmenorrhea (p smaller than 0.01) and side effects from oral contraception (p smaller than 0.01) and in primigravida (p smaller than 0.05). Age was only correlated to the symptom of stabbing pain in the legs in a statistically significant correlation (p smaller than 0.05). The results were tested statistically for significance with the X2-method.
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PMID:[The psychosomatic aspects of complaints of varicose veins during pregnancy. A psychosometric investigation in 345 antenatal patients (author's transl)]. 99 22

Acrodermatitis chronica atrophicans (ACA) was diagnosed in 15 patients from the southern and eastern part of Friesland (the Netherlands). Twelve patients had one leg affected; three had more than one extremity involved. Frequent complaints were fatigue, paraesthesia, swelling and blue discoloration. The symptoms persisted for many years in most cases. The inflammatory stage was observed most frequently (13/15): violet-blue erythema, oedema, firm swelling and nodules. Atrophy (4/15) was observed once in the form of a scleroderma-like lesion. Neuropathy was found in five patients. Histological investigation showed infiltration with lymphocytes and plasma cells (13/15) and atrophy (2/15). Spirochaetes were demonstrated in biopsies of 13 patients. Specific antibodies against Borrelia burgdorferi were found in all patients. ACA appears to be not infrequent and must be distinguished from other inflammatory and vascular diseases, such as chronic venous insufficiency.
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PMID:[Chronic atrophic acrodermatitis; a deceptive form of Lyme borreliosis]. 186 45

Calcium dobesilate was studied in a double-blind trial in 30 normal subjects and in 30 patients with chronic venous insufficiency (CVI). There were no significant alterations in the normal subjects. In patients with CVI the active drug gave significant improvements (p less than 0.01) in the measured volume of the foot and lower limb, in clinical tenderness (p less than 0.05), and in most of the symptoms (including feelings of heaviness, swelling, tiredness, and aching in the lower extremities). Even though the chronic venous insufficiency had existed for an average of fifteen years, a relatively short course of the drug caused considerable, and significant, improvements in a number of signs and symptoms of the disease.
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PMID:A double-blind trial of calcium dobesilate in chronic venous insufficiency. 317 51

Manifestations of chronic venous insufficiency of the lower limbs are related to congenital or acquired stasis in the deep veins, to post-phlebitis occlusion of the deep veins or to stasis in the superficial veins. Functional impairment may be associated with varicose veins or not. Clinical signs include a heavy feeling in the legs, fatigue, and sometimes cramps or impatience in the evening. Sometimes there is a seasonal character to the complaints. The varicosities are localized in the territory of the medial saphenous vein, the lateral saphenous vein, or both and sometimes affect the pelvic region. Complications may occur including hemorrhage of the varicose veins, superficial phlebitis or orthostatic hypotension. An echo coupled Doppler helps determine the therapeutic indications and provides a mapping of the venous system for functional evaluations. Varicose veins result from minute dilatations of superficial vessels. There are exclusively of aesthetic importance. Chronic venous insufficiency can lead to permanent or intermittant oedema of the lower limbs without inflammation. When permanent, a large cold leg fits into a suggestive clinical picture non venous causes of oedema can be determined with an ultrasound exploration. Postphlebitic reactions are the most frequent causes of large cold lower limbs due to venous insufficiency. Poor cutaneous trophism of venous origin includes dermo-epidermitis, pigmented purpura dermitis, capillary ectasia, leukoderma, sclerodermiform hypodermitis and leg ulcers. Superficial venous ulcers are often quite large, painless and chronic. Their prevalence increases with age. Venous ulcers are more often secondary to phlebitis than to varicose veins. The socio-economic impact is great.
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PMID:[Chronic venous insufficiency: clinical aspects]. 817 72

Within the framework of a case observation study involving more than 800 general practitioners, more than 5,000 patients with chronic venous insufficiency (CVI) were treated with standardised horse chestnut extract and followed up at regular intervals. The evolution of the symptoms, tolerability and adverse drug reactions were recorded. All of the symptoms investigated-pain, tiredness, tension and swelling in the leg, as well as itching and the tendency towards edema-all improved markedly or disappeared completely. The results of this study show that rational treatment with horse chestnut extract represents an economical, practice-relevant therapeutic "pillar", which in comparison with compression has the additional advantage of better compliance.
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PMID:[Horse chestnut seed extract--an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency]. 876 39

An open prospective study on the use of the drug Venza for complex variceal disease treatment was conducted. The study included 125 patients aged from 21 to 75. The outcome measures were: patient complaints and medical history, as well as Doppler ultrasound of lower limb veins, arteriovenous index (AVI) and leg circumference at the ankle level for the objective assessment of therapeutic effectiveness. Malleolar circumference decreased by average 0.8+/-0.3 cm. The drug therapy resulted in the regression of clinical signs (leg fatigue heaviness and edema, night palsies). Venza had a positive effect on all evaluated parameters of patient's quality of life. Its clinical effectiveness was estimated as "very good" and "good" in 27.5% and 57.5%, respectively. The study proved the Venza's effectiveness in treatment of patients with lower limb chronic venous insufficiency.
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PMID:[Drug therapy of chronic venous insufficiency with Venza]. 1643 49

The study evaluates to what extent symptoms of chronic venous insufficiency (CVI) and functional venous incompetence as investigated using color-coded duplex ultrasonography may interfere with activities of daily living (ADLs). This study comprises a cross-sectional survey conducted in urban areas surrounding 24 Italian cities. A spontaneous sample of 5,187 subjects (4,457 women [mean age, 54 years] and 730 men [mean age, 61 years]), selected by advertising on television and in newspapers, underwent a clinical examination that included duplex ultrasonography in 3 vein segments in both legs to determine the presence and severity of venous reflux. Subjective perception of lower limb symptoms of CVI and the effect of leg problems on the ability to perform normal ADLs are assessed by means of a self-administered questionnaire. Most of the respondents have some CVI symptoms, with women being 1.5 to 3 times as likely as men to report leg symptoms. The risk of developing the most frequent subjective symptoms such as heaviness and tiredness in the legs is not statistically significantly different for younger subjects compared with older subjects. Advanced age is considered to be a relevant risk factor only for heat sensation and swollen legs. Persons living in southern Italy are at higher risk of almost all lower limb symptoms. Results of duplex ultrasonography performed on 3875 subjects show that fewer than 1 in 5 young persons, regardless of sex, manifest some degree of venous reflux (primarily mild symptoms). The risk of developing venous incompetence increases rapidly with age until it triples among subjects 50 years and older. Adjusting for all other factors, men are on average 1.5 times as likely as childless women to have venous reflux, and the risk increases in the case of family history of CVI or (among women) in the case of past pregnancies. More women than men report that their leg problems affect their ADLs. Pregnancy and living in the south contribute to a reduction in the ability to perform most heavy housework. Although milder lower limb symptoms such as evening heaviness and tiredness in the legs may begin early in life, venous reflux and related symptoms of heat sensation and swollen legs become more pronounced with age, and their severity can be disabling for those afflicted.
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PMID:Effect of chronic venous insufficiency on activities of daily living and quality of life: correlation of demographic factors with duplex ultrasonography findings. 1787 57

Varicose veins (VVs) are the most common manifestation of chronic venous insufficiency, affecting 25% of women and 15% of men. Reticular veins and telangiectasias (spider veins) are found in more than 80% of the general population. VVs produce symptoms of pain, swelling, heaviness, fatigue, and pruritus and predispose patients to complications including bleeding, superficial thrombophlebitis, and ulcerations that interfere with activities of daily living and result in lost time from work. Current treatments for VVs include conservative measures, and when these are unsuccessful, more invasive surgical and endovenous interventions primarily aimed at reducing venous hypertension and preventing progression to chronic inflammation and ulcerations. Surgical procedures including saphenous vein stripping, ligation of the saphenofemoral junction, and ambulatory phlebectomy are effective in the treatment of VVs but are associated with a high complication rate and recovery time. Emerging endovenous therapies, including endovenous laser therapy, radiofrequency ablation, and endovenous foam sclerotherapy, have shown similar efficacy in the treatment of VVs compared with more invasive surgical procedures, with lower complication rates and less time lost from work.
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PMID:Treatment of varicose veins. 1928 22

We present a woman having congenital anomalies of the inferior vena cava and partial anomalous pulmonary venous return from the right lung with atrial septal defect in a 38-year-old. Congenital anomalies of inferior vena cava are rare. They are seen more often in young males. If there are not other anomalies, they are latent for a long time. Peripheral venous thrombosis, chronic venous insufficiency, dyspnea and fatigue are often the first symptoms of these anomalies. Surgical repair of atrial septal defect with partial anomalous pulmonary venous return include provision of durably unobstructed systemic and pulmonary venous pathways, closure of the atrial septal defect, and avoidance of arrhythmias. The diagnosis has been determined by compression ultrasonography with color doppler assessment, multidetector computed tomography angiography and echocardiography.
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PMID:Interrupted inferior vena cava and partial anomalous pulmonary venous return with atrial septal defect in a 38-year-old adult: a case report. 1982 46

Described herein are the findings of an open, prospective, comparative study of 2-month use of Antistax in a total of one hundred and nineteen patients presenting with clinical manifestations of chronic venous disease of class C0 (60 subjects) and class C2,3 (59 patients). Each group was subdivided into two subgroups of patients receiving Antistax at a daily dose of 360 and 720 mg, respectively. The authors studied the dynamics of the extremity's volume during direct plethysmography by means of liquid displacement, measuring the extremity's circumference under the ankles and in the muscular portion of the crus. The degree of subjective symptoms of CVI (increased fatigue of the legs and pain) was assessed by means of a 10-point visual analogue scale. The points of the study were the baseline state and the condition 2 months after medicamentous therapy. It was determined that administration of Antistax at daily doses of 360 and 720 mg for 2 months resulted in a significant decrease in the volume of the affected extremity, which was accompanied by regression of complaints related to venous insufficiency. The patients with class C0 and C2,3 CVI showed a pronounced dose-dependent effect, being more significant in class C2,3 CVI. We conceive it to be expedient that patients presenting with clinically pronounced variants of CVI inducing an increase in the extremity's volume should be given Antistax at a daily dose of 720 mg.
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PMID:[Assessment of dose-dependent effect during phlebotropic therapy of chronic diseases of lower-limb veins]. 2128 Feb 96


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