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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Multiple serum chemical values were examined in 92 patients with chronic glaucoma who were treated with the carbonic anhydrase inhibitors (CAIs) acetazolamide or methazolamide, seeking relationships between serum composition and symptomatic side effects. Of the 92 patients, 44 complained of a symptom-complex of malaise, fatigue, weight loss, depression, anorexia, and loss of libido, which we have found most commonly to threaten continuation of therapy. Patients who had this symptom complex were significantly more acidotic than those without it. Ten of 24 patients who had chemical evidence of excessive acidosis reported a dramatic alleviation of symptoms when sodium bicarbonate was administered, although their serum CO2-combining power changed little. There was no correlation of the symptom complex with serum potassium concentration, except in a few patients who were simultaneously receiving chlorothiazide diuretics for systemic hypertension and who became frankly hypokalemic.
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PMID:Carbonic anhydrase inhibitor side effects. Serum chemical analysis. 88 13

The detection of change in the visual field is confounded by factors associated with the patient response. Sixteen patients who had previously undergone a training regime in automated perimetry over a short time period were followed up to evaluate the longer term learning and fatigue effects. The patients, all attending a glaucoma clinic, were originally naive to automated perimetry. The training period had comprised examination of the right followed by that of the left eye with the Humphrey Field Analyser 630 on each of 3 successive days and again after an interval of 12 days. The follow-up study comprised two examinations on 2 successive days after a follow-up period of between 5 and 15 months (mean 8.7 months). The learning effects present over the initial training period were not observed at the follow-up whilst the fatigue effects in the fellow eye were still apparent.
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PMID:Long-term follow-up of baseline learning and fatigue effects in the automated perimetry of glaucoma and ocular hypertensive patients. 187 40

Monocular and binocular reading curves of 20 patients (4 with cataract, 5 with glaucoma, 11 with maculopathy) were recorded by infrared oculography. Reading speed was found to be directly proportional to the visual acuity of the eye tested. However, the same visual acuity in both eyes does not always mean that the subject reads at the same speed with both eyes. For example, paracentral visual field defects impair reading ability and eyes which appear to have good vision may easily become tired. Twelve of 16 examined eyes with maculopathy showed a significant decrease in reading speed during a reading test lasting no more than 2 minutes. In tests of the same duration cataract patients did not tire; their reading speed increased. Binocular vision helps improve reading speed in cases of maculopathy, and even more so in cases of glaucoma with visual field defects. Attention is drawn to Mackensen's suggestion that measurement of reading speed is a valuable function test, and to the fact that in certain cases fatigue of an eye during reading is a new and measurable criterion of the degree of visual impairment.
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PMID:[Decreased reading speed and rapid fatigue as signs of disordered visual function]. 234 15

The presence of visual field anomalies was measured using Goldmann kinetic perimetry in twelve patients, age 7 to 39 with Gilles de la Tourette syndrome. Refraction to the cupola was carefully controlled. The visual acuity of the group was good to excellent. Visual field alterations were prechiasmal, generally non-symmetric, and best described as arcuate defects, steps, baring of the blind spot and enlargement of the blind spot. Central fields were most commonly affected, i.e., I/2e to I/1B isopters. There was no evidence of glaucoma in any of the patients although two patients exhibited keratoconus and another one manifested moderate to high astigmatism. Visual involvement other than ocular and lid tics have not been reported in Tourette syndrome. This research represents clear evidence of additional physical components in this condition. Automated visual field measurements are not recommended in this population because of the presence of non-predictable tic and vocal behavior (both may result in head/eye movements). Suppression of tic behavior can be very fatiguing. (Eight of twelve of the patients reported exhibited signs of marked fatigue during testing.)
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PMID:Visual field defects detected in patients with Gilles de la Tourette syndrome: preliminary report. 262 81

Visual evoked potential (VEP) abnormality is widely used as an objective indication of visual pathophysiology in the diagnosis of multiple sclerosis. One major limitation of this test is that VEP abnormality is not specific to multiple sclerosis. In an attempt to explore ways of making the VEP test more specific, changes were measured in VEPs caused by superimposing upon the VEP stimulus either a flicker or a moving pattern. The rationale was to test for visual fatigueability, since it is known that some demyelinated axons fatigue rapidly. Of 10 patients with multiple sclerosis, 90% showed VEP fatigue, while none fatigued in the groups of 10 patients with glaucoma and 10 with Parkinson's disease. Fatigue is, however, not completely specific for multiple sclerosis, since three of 10 patients with ocular hypertension showed VEP fatigue.
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PMID:Visual fatigue and visual evoked potentials in multiple sclerosis, glaucoma, ocular hypertension and Parkinson's disease. 608 42

Oral atenolol (25 mg twice daily and 50 mg and 100 mg once daily) and placebo were tested as additional therapy in a double-masked, randomised, cross-over study. Twenty-four patients (16 with chronic simple glaucoma and 6 with ocular hypertension) participated who had an intraocular pressure (IOP) higher than 21 mmHg. The mean fall of intraocular pressure varied between 28% and 36% and was observed 2 to 6 hours after administration. After 2 weeks of treatment there was still a small fall in intraocular pressure (13%) after 12 hours (for the 25 mg dose) and 24 hours (for the 50 mg and 100 mg dose), but this was not significant (p less than 0.5). There was a fall in blood pressure and reduced pulse rate which persisted for at least 30 hours. Some patients complained of tiredness during treatment periods. Oral atenolol may be useful additional therapy for glaucoma.
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PMID:Comparison of ocular hypotensive effects of 3 dosages of oral atenolol. 635 1

A 72-year-old man with epiphora secondary to bilateral canalicular stenosis resulting from long-term treatment with 0.125% to 0.25% echothiophate iodide (phospholine iodide) drops for glaucoma underwent bilateral conjunctivodacryocystorhinostomies with Jones' tubes. Within days after undergoing this surgery, he experienced severe unexplained diarrhea, fatigue, weight loss, and prostration. He cancelled his postoperative ophthalmic appointment because of "medical illness." He required admission to his local hospital where extensive studies were done in an attempt to establish the cause of this life-threatening condition. After stopping the echothiophate iodide drops, all symptoms disappeared within two days. Drug toxicity is a previously unreported complication of conjunctivodacryocystorhinostomy, and this case demonstrates that topical medications have enhanced systemic absorption after lacrimal surgery with placement of fistulizing prosthetic devices. One must be aware of this possible complication, not only with long-acting anticholinesterases, but with topical sympathomimetic drugs (especially in cardiac patients) as well as cycloplegic agents in children.
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PMID:Phospholine iodide toxicity and Jones' tubes. 739 39

Diagnosis of visual function losses in glaucomatous patients depends to a large extent on the analysis of the data collected from corresponding psychophysical tests. One of the main difficulties in obtaining reliable data from patients in these tests is the measurement noise caused by the learning effect, inattention, failure of fixation, fatigue etc. Using Kohonen's self-organising feature map, we have developed a computational method to distinguish between the noise and true measurement and to provide an instant assessment of reliability of the computer-based visual function test. In particular we have experimented with 270 test records from glaucoma patients and glaucoma suspects and found that this method provides a satisfactory way of locating and rejecting noise in the test data, an improvement over conventional statistical methods. This method can also provide doctors with a clear view of the patient's behaviour during the test, thus assisting in their diagnostic decision making process.
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PMID:Identifying the measurement noise in glaucomatous testing: an artificial neural network approach. 784 40

The makers of the Humphrey perimeter have developed a rapid thresholding program, FASTPAC, to address the problems of fatigue and poor test performance associated with prolonged perimetry. The performance of FASTPAC was compared with the standard threshold program of the Humphrey visual field analyser (program 24-2) in 44 glaucoma patients. FASTPAC reduced the mean test time by 35% (from 12.6 to 8.2 minutes), owing to a reduction in the number of stimulus presentations. FASTPAC underestimated the mean deviation (MD) (Wilcoxon, p = 0.007) and corrected pattern standard deviation (CPSD) (Wilcoxon, p = 0.005). The sum of the differences between FASTPAC and the standard program was -1.19 (SD 2.37) dB for MD and 0.97 (2.14) dB for CPSD. The measured difference between the two methods was independent of the value of either MD or CPSD, indicating that the measurement error was just as likely to occur with either early or advanced visual field loss. No difference was noted in short term fluctuation or in the reliability indices of test performance. These results indicate that FASTPAC, while considerably faster, is not as accurate as the standard threshold program at measuring retinal sensitivity in glaucoma. This inaccuracy may be offset in practical terms by greater patient acceptability and by increasing the number of patients capable of performing reliable threshold perimetry because of the reduction in duration of the FASTPAC program.
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PMID:Evaluation of the Humphrey FASTPAC threshold program in glaucoma. 791 59

Well-recognised complications are pulmonary fibrosis, cor pulmonale, glaucoma, cataract and nephrocalcinosis causing failure of lungs, heart, vision and kidneys. Less well-recognised is the post-sarcoidosis chronic fatigue syndrome. The afflicted join sarcoidosis patients' associations because of their profound symptoms of myalgia, fatigue, sleep reversal and low-spiritedness. The symptoms are out of proportion to the lack of physical signs and the absence of objective evidence of sarcoidosis. Management includes unremitting sympathy and replenishment of essential neurochemicals.
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PMID:Complications of sarcoidosis. Chronic fatigue syndrome. 817 98


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