Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Enzyme
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Query: UMLS:C0015672 (
fatigue
)
51,768
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The use of porcine or bovine pericardium biological cardiac valves has as its main disadvantage a relatively short lifespan, with failures due to calcification and
fatigue
. Increasing these valves' durability constitutes a great challenge. An understudied phenomenon is the effect of
flutter
, an oscillation of the leaflets that can cause regurgitation and accelerate calcification and
fatigue
. As a starting point to study how to reduce or prevent these oscillations, a method was developed to quantify the
flutter
frequencies occurring at the point of the valve's full opening. On a test bench that simulates the heart flow, the cusp behaviors of eight biological valves were filmed with a high speed camera at 2000 frames per second at different flow rates and motion capture software obtained the frequencies and amplitudes of the vibrations of each leaflet. Oscillations in the range of 200 Hz with average amplitudes of 0.4 mm were found; larger nominal diameter valves obtained lower values, and bovine pericardial valves had superior performance compared to porcine valves. A dimensionless analysis was performed to find a relationship between the geometric and mechanical properties of the valves with the critical speed of the onset of fluttering. This relationship inspired a method to predict whether
flutter
will occur in the bioprosthesis. This method is a new tool for the consideration of maximizing the life of prosthetic valves.
...
PMID:Quantification and Analysis of Leaflet Flutter on Biological Prosthetic Cardiac Valves. 2792 33
Airplane wing deformation is an important element of aerodynamic characteristics, structure design, and
fatigue
analysis for aircraft manufacturing, as well as a main test content of certification regarding
flutter
for airplanes. This paper presents a novel real-time detection method for wing deformation and flight
flutter
detection by using three-dimensional speckle image correlation technology. Speckle patterns whose positions are determined through the vibration characteristic of the aircraft are coated on the wing; then the speckle patterns are imaged by CCD cameras which are mounted inside the aircraft cabin. In order to reduce the computation, a matching technique based on Geodetic Systems Incorporated coded points combined with the classical epipolar constraint is proposed, and a displacement vector map for the aircraft wing can be obtained through comparing the coordinates of speckle points before and after deformation. Finally, verification experiments containing static and dynamic tests by using an aircraft wing model demonstrate the accuracy and effectiveness of the proposed method.
...
PMID:Airplane wing deformation and flight flutter detection method by using three-dimensional speckle image correlation technology. 2903 74
Wolff-Parkinson-White syndrome is the most common form of ventricular preexcitation and affects 1-3 per 1,000 persons worldwide. Many patients remain asymptomatic throughout their lives; however, approximately half of the patients with Wolff-Parkinson-White syndrome experience symptoms secondary to tachyarrhythmias, such as paroxysmal supraventricular tachycardia, atrial fibrillation, atrial
flutter
, and, rarely, ventricular fibrillation and sudden death. Patients with Wolff-Parkinson-White syndrome may present with a multitude of symptoms such as unexplained anxiety, palpitations,
fatigue
, light-headedness or dizziness, loss of consciousness, and shortness of breath. We report the case of a patient who presented with a plethora of symptoms related to generalized anxiety along with several confounding factors such as psychosocial stressors, chronic
fatigue
secondary to high physical and mental demands at work, a strong family history of anxiety, and a history of substance abuse. Keeping cardiac dysrhythmia within his differential diagnosis allowed for accurate diagnosis and treatment.
...
PMID:Wolff-Parkinson-White Syndrome: A Master of Disguise. 3269 72
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