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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The experience of fatigue in early pregnancy was studied, using a general model of fatigue as the conceptual framework. A convenience sample of 30 women, age 20-35 years, who were at less than 20 weeks' gestation and without health problems were included in the study. Physiologic, psychological, and environmental factors were measured and related to the occurrence and intensity of fatigue. Pearson correlations and content analysis were used to analyze the data. Results showed that a large portion of the sample (90%) experienced fatigue and that this fatigue had a significant impact on their ability to maintain personal and social activities. Significant correlations were observed between fatigue and the physiologic variables of nausea and feeling tired upon awakening from sleep. There was no significant relationship between fatigue and environmental variables such as number of hours worked or the number of children living in the home. In addition, significant correlations were observed between fatigue and psychological variables that included depression, anger, anxiety, and confusion. These data suggest that fatigue is a significant problem for pregnant women and is not relieved by rest. These data further suggest that the fatigue may be related to other physiologic changes, perhaps hormonal, that mediate physiologic and psychological variables, including fatigue.
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PMID:Fatigue in early pregnancy. An exploratory study. 175 16

Adiposis dolorosa or Dercum's disease consists of a painful progressive localized state of obesity with four cardinal symptoms: a) painful circumscribed or diffuse fatty deposits, b) generalized obesity in women usually of menopausal age, c) asthenia, weakness and frequently tendency to fatigue and d) mental phenomena including emotional instability, depression, epilepsy, mental confusion and true dementia. Only a few cases in men have been described. The pain may be treated with intravenous administration of lignocaine or oral mexitil while no causal treatment is known. An illustrative case is reported.
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PMID:[A case of adiposis dolorosa--Dercum's disease]. 150 54

The changes occurring in specific mood states in response to alterations in physical training were assessed in college varsity swimmers. The Profile of Mood States (POMS) was administered at regular intervals during training seasons over a four-year period to 84 female and 102 male swimmers. It was found that female and male swimmers displayed similar mood responses during training in total mood as well as the specific moods of depression, anger, vigor, fatigue, and confusion. Each of these mood states fluctuated correspondingly with alterations in training yardage, with the exception of tension, which remained elevated while training was being reduced. Tension also was higher (p less than 0.05) in the female swimmers in each of the seasons. It is concluded that: 1) changes in specific mood states during training are similar between female and male swimmers, with the exception of tension, and 2) specific mood factors increase and decrease in accordance with alterations in training distance, with the exception of tension, which does not decrease in response to reductions in training.
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PMID:Changes in mood states during training in female and male college swimmers. 179 3

A phase I trial of Roussel-Uclaf recombinant human interleukin 2 (IL 2) was performed on 31 cancer bearing patients of the Institut Gustave-Roussy, Villejuif, and the Institut Curie, Paris. This study allowed to define a schedule for administration of IL 2 in continuous infusion over 5 day cycles. This schedule is manageable in patients without major visceral failure. It is reproducibly feasible in conventional medical oncology units, without specialized intensive care facilities. Toxicities, although numerous, are acceptable for IL 2 doses below 24,000,000 IU/m2/day. There is a close relationship between secondary effect severity and IL 2 doses received. Main toxicities were: fever with chills, fatigue and general discomfort in 23 patients, nauseas and vomiting in 12, diarrhea in 10 and cutaneous rashes with erythema and dermal vascularitis in 13. One peculiar feature of this study was the minimal occurrence of manifestation related to leaky capillary syndrome prominant in other studies. Oliguria, functional renal failure and edema were observed in only 4 patients with functionally unique kidney. Five patients had severe anemia, 2 grade III thrombocytopenia, 1 grade IV hepatic cytolysis, 4 severe confusion episodes and 2 hypothyroidism with anti-thyroid microsome auto-antibodies. All these toxicities were reversible after withdrawal of IL 2 treatment. During this phase I trial, 3 therapeutic objective responses were observed, all 3 occurring in patients with metastatic melanoma treated with IL 2 doses equal to, or above 16,000,00 IU/m2/d. Recombinant IL 2 Roussel-Uclaf thus can be administered through a simple, manageable and efficient regimen.
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PMID:[Phase I trial of a recombinant human interleukin 2. Results in patients with disseminated solid tumors]. 182 63

The purpose of this study was to determine the relationship between psychological states as measured by the Profile of Mood States (POMS) inventory and within-subject variation in running economy (RE) in moderately trained male runners (N = 10). Subjects (ages 20-34 yr) were monitored during treadmill running, five times a week (Monday through Friday) for 4 wk, at 2.68, 3.13, and 3.58 m, s-1. Tension, depression, anger, vigor, fatigue, confusion, and a total mood disturbance (TMD) score were assessed every Friday prior to the treadmill running sessions. Oxygen consumption (VO2) was determined via the open-circuit method during each of the three running paces. VO2 values were averaged over 5 d and three speeds for each week (RE) and were correlated with the weekly TMD scores, resulting in a nonsignificant group correlation of r = -0.28. The within-subject group correlation between TMD scores and RE was r = 0.88. This positive correlation indicates that, when the focus of attention was on within-subject variation, weeks featuring more economical values were associated with more positive mental health profiles. Correlations between average VO2 and the six POMS subscales were tension. r = 0.81; depression, r = 0.73; anger, r = 0.58; vigor, r = -0.60: fatigue, r = 0.18; and confusion, r = 0.60. All correlation coefficients except for fatigue were significantly (P less than 0.01) related to average VO2. In conclusion, it appears that short-term fluctuations in RE of moderately trained male runners are closely tied to their mood state.
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PMID:Mood state and running economy in moderately trained male runners. 188 81

Fourteen patients with metastatic carcinoid tumors were treated with recombinant interferon alpha-2b at a dosage of 3-4 x 10(6) IU s.c. daily or every second day. No objective tumor regression was observed. Six out of 8 patients with carcinoids of the ileum and the caecum showed stable disease lasting for a median of 25 months (range 4-57). In 3 out of 6 patients with carcinoids of rectum, lung and of unknown primary site, stable disease was observed lasting for 2-7 months. The remaining patients had progressive disease. Six out of 9 evaluable patients had a more than 50% reduction of urinary 24 h 5-hydroxyindoleacetic acid excretion lasting for a median of 4 months (range 2-11). Decrease of flushing was noticed in 3 out of 6 evaluable patients and decrease of diarrhea in 5 out of 9 evaluable patients. In 4 patients dose reduction was necessary due to confusion and fatigue.
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PMID:Treatment of metastatic carcinoid tumors and the carcinoid syndrome with recombinant interferon alpha. 189 78

To develop a psychological profile of professional female athletes, specifically of elite tennis players, 16 professional female tennis players from five countries were given the Profile of Mood States to measure six mood states: tension, depression, anger, vigor, fatigue, and confusion. When age was controlled in the design, older female athletes exhibited the "iceberg profile," i.e., they scored higher on the vigor mood state and lower on all other mood states than college-age women. Younger athletes scored like college-age women. These results only partially support the 1987 work of Morgan, O'Connor, Sparling, and Pate.
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PMID:Mood states of professional female tennis players. 194 86

Many of the hundreds of thousands of survivors of polio are now developing postpolio syndrome. Symptoms include progressive muscle weakness, fatigue, decreased endurance, joint and muscle pain, weight gain, respiratory difficulties, and sleep disturbance, often precipitated or exacerbated by a Type-A Personality pattern. A postpolio patient with Type-A Personality was taught self-hypnosis as a vital component of treatment. Pre-post testing included the Profile of Mood States, the State-Trait Anxiety Inventory, the State-Trait Anger Inventory, and the Personal Orientation Inventory; the patient's spouse was interviewed during the follow-up. At the 6-month follow-up, improvements were documented in pain level, depression, self-regard, self-acceptance, capacity for intimate contact, time competence (living in the present), confusion, anxiety, insomnia, and in trait and state anger. Only a mild improvement occurred in fatigue, and no improvement was found in weight control. Follow-up at 12 months confirmed the maintenance of improvements. Self-hypnosis training may prove extremely helpful for postpolio patients and may prove helpful in modifying central characteristics of Type-A Personality.
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PMID:Hypnosis for postpolio syndrome & Type-A behavior. 195 Nov 42

Decompression sickness (DCS) is a well-known hazard of exposure to significant variations in ambient pressure. The diagnosis and management of DCS is frequently a source of confusion. Although the majority of cases are manifested by joint or limb pains (Type I DCS), patients may present with a wide array of symptoms, such as neurologic deficits, headache, fatigue, nausea, and respiratory difficulty. A thorough knowledge of the differential diagnosis and a strong index of suspicion are crucial to the proper management of DCS. Presented herein are two cases of altitude-related DCS which were confused initially with a viral syndrome. A discussion of the symptoms of DCS is included.
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PMID:Decompression sickness presenting as a viral syndrome. 199 34

Thirty-eight healthy outpatients undergoing elective surgical procedures lasting 1-3 h were randomly assigned to receive either desflurane 3% (approximately 0.5 MAC) or isoflurane 0.6% (approximately 0.5 MAC) for maintenance of general anesthesia with nitrous oxide 60% in oxygen after a standardized induction sequence consisting of fentanyl 3 micrograms.kg-1, thiopental 4 mg.kg-1, and succinylcholine 1-1.5 mg.kg-1, intravenously. Although anesthetic conditions were similar during operations in the two treatment groups, significant differences were noted in the recovery profiles as measured by elimination kinetics, psychometric testing, and visual analog scales (to assess subjective feelings). The time required for the end-tidal concentration to decrease by 50% was 2.5 +/- 0.8 min for desflurane vs. 9.5 +/- 3.4 min for isoflurane (mean +/- standard deviation [SD]). Times to awakening and ability to follow simple commands were significantly shorter after desflurane than after isoflurane (5.1 +/- 2.4 vs. 10.2 +/- 7.7 min 6.5 +/- 2.3 min vs. 11.1 +/- 7.9 min, respectively). Postoperatively, patients who received desflurane exhibited less impairment of cognitive function (as measured using the Digit-Symbol Substitution Test) than did those who received isoflurane. Furthermore, visual analog scores indicated that patients receiving desflurane experienced significantly less discomfort (pain), drowsiness, fatigue, clumsiness, and confusion in the early postoperative period. We conclude that desflurane may offer clinical advantages over isoflurane when used for maintenance of anesthesia during outpatient surgical procedures.
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PMID:Recovery profile after desflurane-nitrous oxide versus isoflurane-nitrous oxide in outpatients. 200 Oct 18


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