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Query: UMLS:C0015672 (fatigue)
 51,768 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The first results of a study of Luschka's accessory tubercle and Broca's styloid hypophysis, and especially of osteotendinitis which can arise from musculo-tendinous fatigue in this zone insertion. This osteotendinitis, whose radiological demonstration is difficult and rarely done, can possibly explain undoubtedly certain cases of localized lumbago.
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PMID:[Comments on the accessory tubercle of the lumbar costiform apophysis (author's transl)]. 13 70

The histochemical profiles of myofibrillar adenosine triphosphatase (ATPase), nicotinamide adenine dinucleotide diaphorase (NADDase), and phosphorylase (Pase) activities were studied in the respiratory muscles of the chicken. Most respiratory muscles contained fibers exhibiting 18 possible combinations of staining reactions (dark or light ATPase; dark, intermediate, or light NADDase; dark, intermediate, or light Pase). Fibers that stained light for ATPase constituted as little as 10% of the total population in rectus abdominis, but as much as 32% of the total in costosternalis pars major. Those fibers did not tend to be smaller than fibers that stained dark for ATPase in the respiratory muscles as a group. Assuming these staining characteristics are correlated with functional properties of the fibers, as they are in mammals, the majority of the fibers should contract rapidly (dark ATPase) and be fatigue resistant (dark and intermediate NADDase).
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PMID:Histochemical studies of respiratory muscles of chicken. 14 96

The effects of exercise training and fatique on the contractile properties of rat soleus muscles have been investigated. Prolonged exercise, consisting of 2 h or daily treadmill running, induced small but significant decrease in contraction time, one-half relaxation time, and maximum tetanic tension (Po), and increase in the peak rate of tension development (dP/dt) during a twitch, and an increase in maximum shortening velocity (Vmax). The 20% increase in Vmax was proportional to the previously reported increase in actomyosin ATPase induced by 2 h of daily running. These results indicate that prolonged training can induce modifications of the neurally determined contractile properties of skeletal muscle. To investigate the effects of fatigue, soleus muscles were stimulated in situ with 250-ms trains of 100 Hz at a rate of 110 trains per minute for 30 min. This resulted in a 32% decrease in Po, a 48% decline in peak tetanic dP/dt, and a 12% decrease in Vmax in muscles of untrained animals. Muscles that had adapted to exercise were significantly protected against the decrease in Po (only an 8% decrease) and Vmax (no significant decrease) but not against the decline in peak dP/dt.
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PMID:Contractile properties of rat soleus muscle: effects of training and fatique. 14 94

Electrophysiologic, morphologic, and biochemical definitions of the synapse will be correlated spatially and temporally. Postsynaptic fatigue and facilitation follow oscillations of the free pool of acetylcholine, predicted by the kinetic theory and observed at the electric organ of Torpedo marmorata. The underlying thermodynamic instability exhibits properties of the Na+--K+-dependent hydrolysis of adenosine triphosphate and represents a necessary condition for synaptic memory.
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PMID:On the kinetics of acetylcholine at the synapse. 14 69

This review is the analysis of molecular mechanisms regulating the contraction activity of voluntary muscles. It summarises the data on muscle biochemistry for last decades. Literary and the author's data are devoted to the analysis of the following problems: ionic gradients of skeletal muscles; the energy origin for processes of the contraction initiation; the biochemical basis of electromechanical coupling; the role of a number of biologically active compounds in muscle functioning; regulatory aspects of the energetic supply of a contraction function; the change of muscle properties under the fatigue. The data given make possible to describe a single contraction cycle on the molecular level.
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PMID:[Biochemical mechanisms of muscle contraction regulation]. 14 21

On the basis of the histochemical activity of succinic dehydrogenase, only two fibre-types are distinguished in pigeon pectoralis major muscle. These are narrow "Red" and broad "White". The histochemical activity of myofibrillar ATPase was studied in these two distinct fibre-types. Both fibre-types showed high activity for the ATPase. "Red" fibres of pigeon pectoralis were not alkali-labile, at incubation pH 9.4, as were the "Type I" fibres of both avian and mammalian muscles. Again unlike "Type I" fibres, the "Red" fibres of pigeon pectoralis lacked the characteristic activation of acid-preincubated ATPase reaction. Pigeon pectoralis "Red" fibres are known to possess some characteristics of fast-twitch fibres (e.g. high fat, considerable phosphorylase, fibrillenstruktur myofibrillar arrangement, focal "en plaque" pattern of nerve endings). It is emphasized, therefore, that the pigeon pectoralis "Red" fibres are not equivalent to "Type I or slow-twitch", muscle fibres, but they are possibly "fast-twitch fatigue resistent or Type II Red" muscle fibres.
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PMID:"Red" fibres of pigeon pectoralis major muscle are "type II red". 14 61

Fifty-two male albino rats aged 7, 9, 12 and 18 days and adult, immobilized with d-turbocurarine, were studied. Discharges were triggered from a penicillin focus with electrical pulses of double the threshold intensity needed to evoke an interhemispheric response (IHR). Developmental changes in the IHR and in spontaneous interictal discharges did not differ from the results described in earlier studies. Practically no discharges could be triggered in 7-day old animals (only a few at a very low stimulation frequency). In the other age groups, discharges were triggered at two optimal frequencies, of which the lower one rose from 0.1 to 0.6 c/s during development, while the higher one was relatively stable (about 1 c/s). With higher frequency triggering, marked signs of fatigue of the focus (intermittent triggering, loss of the main negative wave) appeared, especially in young animals. The averaged shape of triggered discharges was similar in 9- and 12-day-old rats. It consisted of a first IHR positivity which triggered the first positive wave of the focal discharge, followed by a high negative wave. In the 18-day-old and adult group, both initial positive waves merged to form a single wave. The duration of the individual waves of the triggered discharge was not significantly shorter than the duration of the corresponding waves of spontaneous discharge.
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PMID:Triggering of discharges from an epileptogenic focus in the rat by stimulation of the contralateral hemisphere. an ontogenetic study. 14 54

Eight cases of fatigue fracture were observed by the authors. In two patients, they presented in metatarsal bones; others were in the lower end of the tibia, in the shaft of the fibula, in the patella, at the upper end of the fibula, in the shaft to the tibia and in the neck of the femur. The main features of these fractues, which occurred in previously intact bones, are reviewed. The role of previous muscle imbalance, or metabolic disturbance, (by age or in pregnancy) is discussed. Good results were obtained by simple immobilization. Surgery may be indicated in the two situations: 1. To eliminate the possibility of a bone tumour by biopsy and, 2. For internal fixation in special sites such as the femoral neck to avoid coxa vara or when healing is very slow, as occurs particularly in the femoral shaft.
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PMID:[Fatigue fractures: apropos of 8 cases]. 14 4

Premature infants tolerate respiratory loads poorly. This may reflect incomplete development of the ventilatory muscles (VM) causing poor resistance to fatigue. To study the developmental pattern of human VM, 31 postmortem specimens of diaphragm and intercostal muscles were obtained. Individual muscle fibers were classified as type I (slow-twitch, high-oxidative) or type II (fast-twich, low-oxidative) using histochemical staining methods for myofibrillar adenosine triphosphatase (M-ATPase) (pH 10.30) and nicotinamide adenine dinucleotide (NADH) tetrazolium reductase. In the diaphragm, premature infants (less than 37 wk gestation) had only 9.7 +/- 1.3% type I fibers, full-term newborns 25.0 +/- 1.1%, and older subjects (greater than 2 yr of age) 54.9 +/- 1.3%. There was no further increase after 8 mo postpartum. In the intercostal muscles, premature infants had only 19.0 +/- 4.8% type I fibers, full-term newborns 45.7 +/- 1.3%, and older subjects 65.2 +/- 2.6%. There was no further increase after 2 mo postpartum. These findings suggest the ventilatory muscles of newborn infants are more susceptible to fatigue than those of older subjects. This may contribute significantly to respiratory problems in the neonate.
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PMID:Developmental pattern of muscle fiber types in human ventilatory muscles. 14 79

A questionnaire study on work conditions, work organization, leisure time, social problems, and health was directed toward active and retired locomotive engineers. This article mainly presents responses of the active engineers. The active locomotive engineers quoted the irregular work hours as the worst occupational problem. They judged noise and vibration in the locomotive cabs as disturbing. The majority of the desired changes in the work and work conditions concerned work time. The most common complaints given on the questionnaire were back trouble, hypertension and dermatitis. Tiredness and exhaustion were the most prevalent neuropsychological symptoms. A retrospective follow-up survey on invalidity and mortality was made. Trainmen and railroad clerks were used as reference cohorts.The engineers had relatively high invalidity and mortality rates in comparison to the reference groups, especially with respect to cardiovascular diseases and malignant tumors. Higher rates for disease of the digestive system and hearing loss were also suggested by the results.
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PMID:Work conditions and health of locomotive engineers. II. Questionnaire study, mortality and disability. 15 82


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