Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0014848 (achalasia)
 2,804 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 179
AAAS 61
She 60
proton pump 42
reserved 40
ACTH 35
gut 34
calcium channel 22
beta-endorphin 22
Mol 19
POEM 18
gastrin 13
nitric oxide synthase 12
ACTH receptor 11
ACG 10
HLA 9
p53 9
adrenocorticotropic hormone 8
polypeptide 7
MRI 7
nuclear pore protein 7
MIM 6
insulin 6
Alport syndrome 5
cytokine 5
Pol 5
substance P 5
collagen 5
somatostatin 5
ENT 5
acetylcholinesterase 5
axonal 5
PABPN1 4
nodal 4
vasoactive intestinal peptide (VIP) 4
nucleoporin 4
San 4
AAA 4
HLA class II 4
vasoactive intestinal peptide 4
IRP 3
enigma 3
neuropeptide Y 3
Vasoactive intestinal peptide 3
ATP 3
neuronal nitric oxide synthase 3
DES 3
RET 3
guanylyl cyclase 3
melanocortin 2 receptor 3
pancreatic polypeptide 3
PGP 9.5 3
phosphodiesterase 3
GMPPA 3
version 3 3
IFN 3
CD8 3
CD4 3
secretin 3
X-linked 3
novel gene 3
CO2 3
c-kit 3
JAMA 2
rhabdomyosarcoma 2
S100 2
DQ1 2
eosinophil cationic protein 2
WD-repeat protein 2
type II keratin 2
calcineurin inhibitor 2
Gen 2
calcitonin 2
strabismus 2
COL4A6 2
HLA-DR 2
neurofibromatosis 2
5-hydroxytryptamine 2
enolase 2
MRAP 2
cholecystokinin 2
neuron-specific enolase 2
mast cell 2
GIF 2
GMPPB 2
lacrimal 2
non-Hodgkin's lymphoma 2
GUCY1A3 2
COL4A5 2
thyroid stimulating hormone 2
glucagon 2
Neuropeptide Y 2
ALD 2
p21 2
HLA-DQ 2
VIP 2
glutamic acid decarboxylase 2
guanylate cyclase 2
Hop 2
KIT 2
beta 1 2
anonymous 2
CD20 2
DQB1 2
lymphoid 2
stem cell factor 1
POLG 1
Human leukocyte antigen 1
CCK 1
ARMS 1
Pseudomonas 1
FGD2 1
GABA 1
LHX4 1
signal transducer and activator of transcription 6 1
granzyme B 1
IL10 1
FISH 1
PRA 1
eosinophil-derived neurotoxin 1
cystatin C 1
factor VIII 1
ferritin heavy chain 1
alpha-fetoprotein 1
myoglobin 1
eosinophil major basic protein 1
nuclear pore complex protein 1
DQA1 1
NDC1 1
MHC 1
FOXP1 1
thyroglobulin 1
nitric oxide synthase 1 1
CGRP 1
interacting protein 1
DIC 1
MIB 1
AAS 1
PEO 1
VIII 1
aquaporin-4 1
IL-3 1
lymphotoxin 1
IL-23 1
STH 1
asymmetrical 1
Ki-67 1
CPR 1
lamin A 1
progerin 1
OCT 1
Steroidogenic acute regulatory protein 1
POM121 1
TXNRD2 1
TNF 1
TNF-alpha 1
renin 1
Renin 1
BID 1
CAS 1
endoplasmic reticulum 1
MAS 1
keratin 1
UDP-glucuronyltransferase 1
epithelial cadherin 1
TPIT 1
cyclin D1 1
neurotrophic factor 1
autosomal recessive) 1
CSF 1
CSI 1
FEV 1
CRC 1
SPA 1
human leukocyte antigen class II 1
COPD 1
SCL 1
GTP 1
HLA DQA1 1
epidermal growth factor receptor 1
dopamine beta-hydroxylase 1
orphan nuclear receptor 1
coagulation factor VIII 1
STX 1
C30 1
myogenin 1
gonadotropin deficiency 1
H18 1
NR0B1 1
IL-22 1
ECM 1
SSAT 1
DAX1 1
CD117 1
MAC 1
unknown function 1
fused 1
Rho 1
nicotinamide nucleotide transhydrogenase 1
tyrosine kinase 1
STAR 1
cell surface receptor 1
achalasia variant 1
EDRF 1
NNT 1
non-muscle 1
HuC 1
NSE 1
major histocompatibility complex 1
DAG 1
pol 1
LMN 1
rheumatoid factor 1
GDP-mannose pyrophosphorylase A 1
POU1F1 1
Rheumatoid factor 1
ubiquitin 1
HLA-DRB1 1
GDP 1
CPI-17 1
Ban 1
ghrelin 1
prolactin 1
TLR4 1
complement component C9 1
tyrosine kinase receptor 1
BII 1
CD31 1
glial cell line-derived neurotrophic factor 1
albumin 1
fruitless 1
SOX10 1
PC1 1
cage 1
PCS 1
SMC 1
PDS 1
IL-6 1
MCS 1
muscarinic receptor 1
EAC 1
transcobalamin II 1
ATG16L1 1
adenylate cyclase 1
pT1 1
prealbumin 1
autoantigen 1
dihydropyrimidine dehydrogenase 1
transgelin 1
catalase 1
GAD 1
glutathione reductase 1
HC1 1
mineralocorticoid receptor 1
Wilson disease 1
DOS 1
chromosome 21 1
microtubule-associated protein 1B 1
AChE 1
synapsin I 1
TCS 1
brain) 1
p36 1
Phox2b 1
KRT8 1
long chain 1
peroxidase 1
Calcitonin 1
neural cell adhesion molecule 1
pseudocholinesterase 1
phosphatase 1
IL23R 1
HD3 1
EGR 1
GP210 1
dilute 1
ubiquitin-protein ligase 1
elastin gene 1
prostate-specific membrane antigen 1
TIA-1 1
Men 1
CD43 1
SGPL1 1
p16 1
MIC 1
alpha-1 antitrypsin 1
CYP11A1 1
gag 1
IL-17 1
GSH 1
PASP 1
HLA-DQB1*05 1
lamin A/C 1
HPD 1
myosin light chain kinase 1
TGA 1
SOD2 1
ERK 1
cytochrome 1
HPRT 1
tumor necrosis factor alpha 1
B12 1
HD1 1
CISS 1
thioredoxin reductase 2 1
Smith-Lemli-Opitz syndrome 1
estrogen receptor 1
CPAP 1
MIS 1
ADRACALIN 1
PEF 1
ALS 1
UBR1 1
SSA 1
HLA-B 1
leptin 1
hole 1
superoxide dismutase 1 1
panhypopituitarism 1
STS 1
more...
Disease
achalasia 2804
dysphagia 853
Heller 499
gastroesophageal reflux disease 456
Esophageal 379
esophageal spasm 194
cancer 174
esophagitis 169
Esophagus 158
Esophagus 158
carcinoma 117
tumor 116
adrenal insufficiency 93
AAA 84
hiatal hernia 84
megaesophagus 72
Barrett's esophagus 66
esophageal cancer 64
reflux esophagitis 59
esophageal cancer 59
Chagas 59
squamous cell carcinoma 59
scleroderma 56
adenocarcinoma 54
gastroparesis 47
esophageal dysmotility 47
dysplasia 32
aspiration pneumonia 31
failure to thrive 27
esophageal stricture 26
rare disease 24
neuropathy 23
asthma 21
carcinoma of the esophagus 20
Zenker's diverticulum 20
diabetes 19
pneumonia 19
esophageal varices 19
irritable bowel syndrome 19
malnutrition 18
obesity 18
dyspepsia 17
leiomyoma 17
autonomic neuropathy 17
mental retardation 16
megacolon 16
mental retardation 16
duodenal ulcer 15
mediastinitis 15
anorexia nervosa 14
anal fissure 14
pneumothorax 14
hernia 14
Down syndrome 13
Parkinson's disease 13
emphysema 13
sepsis 13
muscular atrophy 13
stroke 12
sepsis 12
neuromuscular disorder 12
peptic ulcer 12
gastric cancer 12
Esophageal perforation 12
paraesophageal hernia 12
celiac disease 12
metastases 12
dyskinesia 11
empyema 11
varices 11
incontinence 10
hypertension 10
amyloidosis 10
West 10
PSS 9
inflammatory bowel disease 9
Crohn's disease 9
herpes simplex 9
Mycobacterium 9
Thoracic 9
esophageal atresia 9
morbid obesity 9
Eosinophilic esophagitis 8
ileus 8
Syndrome 8
Best 8
incontinence 8
Schatzki's ring 8
lung carcinoma 8
lymphoma 8
neurological disease 8
polyneuropathy 8
peripheral neuropathy 8
optic atrophy 8
Alport syndrome 8
sarcoidosis 8
Esophageal squamous cell carcinoma 7
Oropharyngeal dysphagia 7
genetic disorder 7
bowel obstruction 7
gastrointestinal disease 7
tylosis 7
organic disease 7
enterocolitis 7
bronchiectasis 7
rheumatoid arthritis 7
chylothorax 7
gallstones 7
hypoglycemia 7
dementia 7
pancreatitis 6
familial dysautonomia 6
Plummer-Vinson syndrome 6
esophageal candidiasis 6
Esophageal dysphagia 6
respiratory failure 6
infectious diseases 6
cold 6
multiple endocrine neoplasia 6
anemia 6
SEM 6
eosinophilia 6
dysphonia 6
tuberculosis 6
dysphasia 6
virus infection 6
heart failure 5
Addison's disease 5
bulimia nervosa 5
Hodgkin's disease 5
coronary artery disease 5
leiomyosarcoma 5
depression 5
herpes 5
cirrhosis 5
fecal incontinence 5
lung cancer 5
Zollinger-Ellison syndrome 5
eating disorder 5
gastric ulcer 5
Adenocarcinoma 5
peritonitis 5
carcinogenesis 5
recurrent pneumonia 5
motor neuron disease 5
myopathy 5
Nutcracker esophagus 5
xerostomia 5
deafness 5
amyotrophic lateral sclerosis 5
Esophageal adenocarcinoma 5
systemic disease 5
dysautonomia 5
strabismus 5
autoimmune disease 5
mesothelioma 5
Cricopharyngeal achalasia 4
adenocarcinoma of the stomach 4
gastritis 4
abdominal aortic aneurysm 4
paraneoplastic syndrome 4
cystic fibrosis 4
migraine 4
type 1 diabetes 4
polymyositis 4
Reflux esophagitis 4
tracheomalacia 4
connective tissue disease 4
confusion 4
hyperkeratosis 4
parkinsonism 4
pernicious anemia 4
eosinophilic gastroenteritis 4
liver disease 4
rumination 4
respiratory disease 4
ulcerative colitis 4
colorectal cancer 4
Thorax 4
melanoma 4
lung disease 4
Addison's disease 4
lymphadenopathy 4
myocardial infarction 4
portal hypertension 4
ALD 4
myocardial ischemia 4
muscular dystrophy 4
congestive heart failure 4
Brown 4
Primary achalasia 4
ischemia 4
candidiasis 4
premalignant condition 4
primary disorders 3
ICC 3
carcinoma in situ 3
bezoar 3
osteoporosis 3
immunodeficiency 3
measles 3
wasting 3
hypothyroidism 3
aerophagia 3
chronic pancreatitis 3
renal cell carcinoma 3
pneumopericardium 3
renal disease 3
ICC 3
hyperphagia 3
DES 3
cytomegalovirus 3
Still 3
stromal tumors 3
Malignancy 3
fits 3
chalasia 3
neurogenic bladder 3
ganglioneuromatosis 3
malignant mesothelioma 3
colitis 3
sensory neuropathy 3
lung abscess 3
chronic obstructive pulmonary disease 3
hepatocellular carcinoma 3
epilepsy 3
chronic bronchitis 3
fungal infection 3
microcolon 3
bronchopneumonia 3
binge eating 3
varicella 3
intellectual impairment 3
head and neck cancer 3
developmental delay 3
enteropathy 3
Mallory-Weiss syndrome 3
myasthenia gravis 3
Luminal 2
Stomach 2
alcoholism 2
skin disease 2
Infection 2
carcinoid 2
diverticulitis 2
OSX 2
aggression 2
ARF 2
bronchogenic carcinoma 2
cognitive impairment 2
terminal disease 2
neurofibromatosis 2
Adie 2
dermatomyositis 2
tobacco abuse 2
emotional stress 2
plaque 2
adenoma 2
pulmonary hypertension 2
plexopathy 2
Frey 2
Boerhaave's syndrome 2
cardiovascular disease 2
AIDS 2
polio 2
paraplegia 2
psychogenic disorders 2
Stomach 2
obstructive sleep apnea 2
disabling disease 2
familial adenomatous polyposis 2
sarcoma 2
Horner's syndrome 2
neuroticism 2
Stomach 2
rhinitis 2
arthritis 2
lipoma 2
rhabdomyosarcoma 2
Colon 2
HIV 2
pancreatic cancer 2
Cholangiocarcinoma 2
esophageal ulceration 2
respiratory infection 2
cardiomyopathy 2
trisomy 2
adenocarcinoma of the lung 2
congenital disorder 2
hypertrophic osteoarthropathy 2
Colon 2
pericarditis 2
Raynaud's phenomenon 2
systemic lupus erythematosus 2
gastrointestinal stromal tumor 2
hepatitis C 2
DM1 2
Cholangiocarcinoma 2
prostate cancer 2
myositis 2
encephalitis 2
delusions 2
renal failure 2
chronic disease 2
MAC 2
Turner syndrome 2
non-Hodgkin's lymphoma 2
Horner syndrome 2
heart disease 2
sensorineural hearing loss 2
ectodermal dysplasia 2
moyamoya 2
edentulous 2
Burkitt's lymphoma 2
malabsorption 2
psoriasis 2
ureter 2
Wernicke's encephalopathy 2
Addisonian crisis 2
pylorospasm 2
more...
Symptom
regurgitation 202
chest pain 200
pain 111
heartburn 98
vomiting 94
cough 46
anesthesia 44
spasm 42
constipation 42
weakness 21
respiratory distress 17
discomfort 17
discomfort 17
diarrhea 16
chronic constipation 15
stridor 15
dyspnea 14
abdominal pain 14
angina 12
dystonia 12
fatigue 10
epigastric pain 9
nausea 9
incoordination 8
belching 7
blepharospasm 7
spasticity 7
ataxia 7
hoarseness 7
dysarthria 6
wheezing 6
cerebellar ataxia 5
chronic cough 5
cyanosis 5
syncope 5
seizures 5
Respiratory symptoms 5
ENT 5
Regurgitation 4
anorexia 4
headache 4
bloating 4
Gastrointestinal symptoms 3
tremor 3
abdominal discomfort 3
cachexia 3
nausea and vomiting 2
shortness of breath 2
nocturnal cough 2
starvation 2
drooling 2
paresis 2
hypotonia 2
productive cough 2
excessive sweating 2
analgesia 2
Non-cardiac chest pain 2
acidity 2
asthenia 2
Motor dysfunction 2
collapse 2
dry eye 2
back pain 2
hyperemesis gravidarum 2
hypertonia 2
paraparesis 1
splenomegaly 1
CSR 1
exertional dyspnea 1
aphagia 1
No adverse effect 1
nasal discharge 1
neurological disability 1
numbness 1
dysesthesia 1
dizziness 1
bladder pain 1
retrosternal discomfort 1
rhinorrhea 1
dysuria 1
emaciation 1
retching 1
tinnitus 1
enuresis 1
right upper quadrant pain 1
Air trapping 1
abdominal fullness 1
arthralgia 1
abnormal gait 1
myoclonus 1
tachypnea 1
Wind 1
flushing 1
rales 1
Muscle fibrosis 1
halitosis 1
sore throat 1
hemiplegia 1
hemoptysis 1
Thoracic pain 1
hepatomegaly 1
erythema 1
muscular incoordination 1
chest tightness 1
Deglutitive inhibition 1
hypercapnia 1
thinning 1
vertigo 1
overweight 1
hypoproteinemia 1
hypothermia 1
atypical chest pain 1
Retrosternal pain 1
acute abdomen 1
colic 1
Spastic 1
chills 1
muscle rigidity 1
inanition 1
persistent cough 1
painful swallowing 1
Drug
Cardiovasc 34
Botox 19
Monit 5
BOTOX 5
ENT 5
nitroglycerin 5
Lugol 4
EDR 3
Atropine 3
Hypaque 2
Zmax 2
Buscopan 2
Azithromycin 2
Diphenhydramine 2
BoNT/A 1
Glucagon 1
Gastro 1
Edrophonium chloride 1
Histalog 1
Dial 1
Coral 1
lysine 1
Nesiritide 1
CPR 1
IL-2 1
Dihydroergotamine 1
CSF 1
Scopolamine 1
Vicryl 1
Dakar 1
Leaf 1
Allergen 1
Ferrous sulfate 1
Asthma 1
CSI 1
Prednisone 1
Omeprazole 1
Histalog 1
Enzyme
NO synthase 7
ERK 6
guanylate cyclase 5
NADPH-diaphorase 5
acetylcholinesterase 5
botulinum neurotoxin 4
NOS 4
phosphodiesterase 3
cholinesterase 3
enolase 2
catalase 1
protein kinase C 1
adenylate cyclase 1
MCS 1
peroxidase 1
dihydropyrimidine dehydrogenase 1
PRA 1
protein phosphatase 2A 1
mitogen-activated protein kinase 1
hypoxanthine-guanine phosphoribosyltransferase 1
UDP-glucuronosyltransferase 1
transhydrogenase 1
luciferase 1
dopamine beta-hydroxylase 1
GDP-mannose pyrophosphorylase 1
renin 1
CPR 1
ubiquitin-protein ligase 1
creatine kinase 1
granzyme B 1
glutathione reductase 1
protein kinase 1
alkaline phosphatase 1
myosin light chain kinase 1
prostate-specific membrane antigen 1
dihydropyrimidine dehydrogenase 1
DNA polymerase 1
Compound
barium 251
Clin 239
Dec 172
water 45
ACTH 35
calcium 34
nitric oxide 30
DNA 20
His 17
CO2 12
Nifedipine 9
sulfate 7
mercury 6
sodium 6
PPI 6
iodine 5
Neuronal 5
phosphate 5
cGMP 5
aldosterone 5
galactose 4
nitrate 4
AAA 4
arginine 4
bromide 4
oxygen 4
IPN 3
Cardiol 3
Adrenal 3
Asp 3
HCl 3
Luminal 3
Salix 3
ISDN 3
DES 3
Atropine 3
Sildenafil 3
ATP 3
Edrophonium 3
Estrogen 3
potassium 2
cysteine 2
tryptophan 2
Insulin 2
Allergan 2
aspartic acid 2
cAMP 2
Pentagastrin 2
Verapamil 2
CIT 2
aspartic acid 2
salt 2
5-FU 2
DQ1 2
tryptophan 2
tryptophan 2
tyrosine 2
Diphenhydramine 2
tryptophan 2
5-HT 2
Ach 2
aspartic acid 2
DSM 2
aspartic acid 2
hydrogen 2
TBE 2
iron 2
glucose 2
Optimal 2
zinc 2
DTPA 2
TSH 2
Hypaque 2
Spironolactone 1
Botulinum toxin type A 1
Mefloquine 1
EDTA 1
Thyroid 1
ANA 1
Dial 1
Verapamil 1
Austin 1
TNF 1
PPD 1
6-12 1
ethanol 1
acrylamide 1
DEP 1
DHC 1
GABA 1
Diltiazem 1
acetic acid 1
TAA 1
Diltiazem 1
Pyrazinamide 1
Lactulose 1
acetate 1
Salt 1
MMC 1
MIC 1
H2S 1
Vitamin D 1
GSH 1
Lactate 1
Cortisol 1
A 3 1
GDP 1
silver 1
DOS 1
phosphorus 1
UDP-galactose 1
Prednisone 1
A 1 1
THE 1
Sodium 1
Calcitonin 1
CAA 1
Polypeptide 1
tin 1
Glucagon 1
DNP 1
BMC 1
Hemoglobin 1
GSH 1
SEE 1
IAS 1
noradrenaline 1
Rifampicin 1
glutamic acid 1
Mefloquine 1
GTP 1
A 42 1
acetaldehyde 1
Isoproterenol 1
ASA 1
PAC 1
ANA 1
nicotinamide 1
GABA 1
Dihydroergotamine 1
Naloxone 1
PPD 1
lysine 1
folinic acid 1
copper 1
gamma-aminobutyric acid 1
Omeprazole 1
glutamate 1
Pac 1
DEP 1
N-acetylaspartate 1
Bethanechol 1
aldehyde 1
Parenteral 1
Ferrous sulfate 1