Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014848 (achalasia)
 2,804 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Increasing dysphagia and weight loss between 3 and 30 kg developed in eight patients aged 27-70 years (mean age 53 years) within a period of 1.5 to 12 months. In five patients X-ray film showed the typical pattern of achalasia with dilatation of the tubular oesophagus and a smooth taper of the terminal part. Although in all patients the cardia became patent only after the endoscope had been advanced by pushing it forward to overcome stenosis or after bougienage, and although the malignoma had always been included in differential diagnostic considerations, a malignoma was identified only three times in 30 histological examinations. Oesophageal manometry demonstrated findings characteristic of achalasia in five patients, in three patients the examination could be performed only incompletely. In six patients computed tomography revealed pathological hypertrophy of the cardiac wall. Intraoperatively all cardiac tumours were in an advanced stage.
Dtsch Med Wochenschr 1988 Dec 23
PMID:[Achalasia as a mask of cardial carcinoma]. 320 19

We report an unusual case of bilateral recurrent laryngeal nerve palsy caused by gross oesophageal distension due to achalasia.
Postgrad Med J 1988 Dec
PMID:Distended oesophagus as a cause of bilateral recurrent laryngeal nerve palsy. 325 17

Achalasia is often a familial disease and may be inherited in association with other familial defects. I report a patient born with a familial facial dysostosis, Treacher Collins syndrome, who also has achalasia to propose that these two defects are associated familial disorders in this patient.
J Clin Gastroenterol 1987 Dec
PMID:Treacher Collins syndrome and achalasia. 344 34

The occurrence of hiatal hernia and achalasia in the same patient is considered to be extremely rare. There have been very few reports regarding this association. An extensive review of achalasia cases at the Cleveland Clinic is presented, with emphasis on the frequency of concomitant hiatal hernia. Our results indicate that the presence of a hiatal hernia makes the diagnosis of achalasia unlikely in patients presenting with esophageal symptoms. However, it does not completely exclude coexistence of this esophageal motility disorder, as the present study reveals that these two entities are infrequently found together.
Am J Gastroenterol 1987 Dec
PMID:Hiatal hernia in patients with achalasia. 368 4

A retrospective survey was made of all the patients resident in the Nottingham area who presented with achalasia between 1959 and 1983. Initial treatment consisted of pneumatic bag dilatation in 26, hydrostatic bag dilatation in one and surgical cardiomyotomy in 22. Those treated by dilatation were older (mean age 52 years) than those treated by cardiomyotomy (mean age 42 years). Seven patients died without receiving active treatment because of old age and infirmity and in 6 this occurred before the introduction of endoscopic dilatation to the area. Initial treatment by cardiomyotomy was associated with a lower recurrence rate than treatment by bag dilatation but with a longer stay in hospital and a higher incidence of complications including empyema, chest infections and oesophageal stricture.
J R Soc Med 1986 Dec
PMID:Audit of surgical and pneumatic/hydrostatic treatment of achalasia in a defined population. 380 41

In 39 patients cardiospasm was associated with a hiatal hernia or the latter was formed in the process of treatment by cardiodilatation. An analysis of results of the treatment has shown that pneumocardiodilatation under control of esophagomanometry should be considered the method of choice in the treatment of such patients. The decreased gradient of the gastroesophageal pressure up to 12-14 mm of mercury is responsible for prevention of reflux-esophagitis. Operative treatment is indicated when cardiodilatation is ineffective or the manometric control is impossible. Cardiomyotomy in combination with an "incomplete" fundoplication is preferable. There are no good reasons for performing fundoplication after Nissen in patients with cardiospasm.
Vestn Khir Im I I Grek 1985 Dec
PMID:[Surgical procedure in joint cardiospasm and cardial hiatal hernia]. 383 39

The anaesthetic management is described of a nine-month-old male for surgical palliation of the the functional abnormalities associated with Opitz-Frias syndrome. Features of this syndrome of interest to anaesthetists include recurrent pulmonary aspiration of intestinal contents, achalasia of the oesophagus, subglottic stenosis, hypertelorism, micrognathia and a high arched palate. No previous reports of anaesthesia for patients with this condition have been identified.
Anaesthesia 1985 Dec
PMID:Opitz-Frias syndrome. A case with potentially hazardous anaesthetic implications. 408 47

Result of operative treatment in 196 cases of achalasia was reviewed. The procedures employed include cardiolysis, Heller's extramucosal myotomy, Wendel's cardioplasty, Heyrovsky's esophagocardiostomy, with and without pyloroplasty, cardiac resection and esophagocardioplasty with gastric patch. Follow-up study on 166 cases revealed that the result was classified as good in 99 cases or 59.6 per cent and improved in 46 cases or 27.7 per cent. Overall satisfactory result was obtained in 87.3 per cent. When the result was broken down to groups following three classifications, i.e. according to X-ray, endoscopic and manometric findings, the interesting correlation emerged. Heller's myotomy and esophagocardioplasty with gastric patch gave best results in early stage of achalasia, while in later stage the latter procedure seems to be the operation of choice.
Jpn J Surg 1974 Dec
PMID:Esophagocardioplasty with gastric patch in the treatment of achalasia. 446 69

The effect of the beta2-adrenergic agonist, carbuterol, was studied on the lower esophageal sphincter (LES) pressure in normals and in patients with achalasia. In normals, the mean LES pressure decreased from 23.1 +/- 6.2 mm Hg (mean +/- SEM) to 16.0 +/- 5.0 mm Hg at a 4.0-mg dose of carbuterol (P less than 0.05). In patients with achalasia, the mean LES pressure decreased from 50.1 +/- 5.1 mm Hg to 22.7 +/- 2.4 mm Hg after a 4.0-mg dose of carbuterol (P less than 0.01). The duration of action following oral administration exceeded 90 min. These studies indicate that the LES in man has beta2-adrenergic receptors that mediate a reduction in pressure. The magnitude of LES pressure reduction in patients with achalasia suggests that this drug may be of therapeutic benefit.
Dig Dis Sci 1982 Dec
PMID:Effect of an oral beta2-adrenergic agonist on lower esophageal sphincter pressure in normals and in patients with achalasia. 612 17

Achalasia has been purported to be a risk factor for the development of esophageal carcinoma. To test the validity of this association at the Yale-New Haven Hospital (YNHH) and its major affiliate, the West Haven Veterans Administration Medical Center (WHVA), two approaches were employed: (1) a prospective study identifying 100 subjects with manometrically documented achalasia for the development of esophageal cancer; (2) a retrospective review of esophageal cancer patients admitted to the YNHH and the WHVA from 1971 through 1981 for any evidence of achalasia. No cases of esophageal carcinoma were identified in the 91 evaluable achalasics. No case of achalasia was found or even suggested in association with the 153 cases of esophageal cancer reviewed. Our findings do not substantiate the association of achalasia and esophageal carcinoma. The clinical implications of this conclusion on surveillance and follow-up of achalasia patients are discussed.
Dig Dis Sci 1984 Dec
PMID:Achalasia as a risk factor for esophageal carcinoma. A reappraisal. 649 28


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