Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0014848 (
achalasia
)
2,804
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Lower oesophageal sphincter supersensitivity to gastrin I and cholinergic stimulation has recently been described in patients with
achalasia
. To determine the pathogenesis of this finding, the lower oesophageal sphincter was tested to a cholinesterase inhibitor, edrophonium chloride.
Edrophonium chloride
significantly increased the lower oesophageal sphincter pressure both in normal subjects and in patients with
achalasia
. The preservation of this response in the presence of denervation supersensitivity suggested intact postganglionic cholinergic nerves and, thus, a preganglionic site of denervation in
achalasia
.
...
PMID:The site of denervation in achalasia. 506 32
