Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014848 (achalasia)
 2,804 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary esophageal motor disorders are rare, but they respond well to surgery if they are accurately diagnosed and if treatment carefully follows the fundamental principles of management. In the lower esophagus the most important primary disorders are achalasia, diffuse esophageal spasm, and scleroderma. Upper esophageal primary disorders are mostly rare; however, problems of age and neurologic diseases are a significant source of debility, making their management important. Details of investigation and management have been outlined in this article.
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PMID:Esophageal motor disorders. 310 43

Modern operative treatment of motor dysfunction of the esophagus began in 1949 with the recognition that anastomotic procedures that bypass or destroy the distal esophageal sphincter are associated with the development of reflux esophagitis and stricture. Thirty years later, reflux esophagitis related to esophagomyotomy or intrinsic esophageal disease remains the dominant concern and challenge. This review examines the current status of operative procedures for the management of three important primary disorders of esophageal motility: achalasia, diffuse esophageal spasm, and scleroderma. Relief of esophageal obstruction by esophagomyotomy or reconstruction is the common surgical goal. The addition of a fundoplication procedure to discourage esophageal reflux remains controversial in each disorder. Esophageal resection may become necessary when stricture persists or esophagomyotomy fails to provide lasting relief of dysphagia.
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PMID:Operation for motor dysfunction of the esophagus. 735 72

This article presents the normal physiology of esophageal peristalsis. It discusses current approaches to the diagnosis and treatment of primary disorders of the esophagus, including achalasia, nutcracker esophagus, diffuse esophageal spasm, as well as the secondary disorder, scleroderma.
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PMID:Esophageal physiology and pathophysiology. 824 29