Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014848 (achalasia)
 2,804 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Only 18 or 83 patients who had had a cardiomyotomy for achalasia could be induced to reflux barium. Mucosal herniation through the myotomy was shown in most by radiography. Perfusion manometry showed a higher pressure zone in the oesophagogastric junction region in 22 of 24 patients studied. This high pressure zone responded to an increment in abdominal pressure by a greater increment. The same response was seen in a patient with a small hiatal hernia and myotomy. We concluded that the persisting high pressure zone seen by perfusion manometry is likely to be caused by the hiatus, and that the hiatus rather than the sphincter is likely to be responsible for the incremental response of the high pressure zone to increased abdominal pressure. The anti-reflux mechanism after cardiomyotomy is more likely to be the hiatal mechanism than persisting sphincter fibres.
Thorax 1978 Oct
PMID:The anti-reflux mechanism after cardiomyotomy. 72 25

A case of acute thoracic inlet obstruction presenting as a rare complication of achalasia is described. The probable mechanism, diagnosis, and management are discussed.
Thorax 1976 Aug
PMID:Acute thoracic inlet obstruction in achalasia of the oesophagus. 96 4

Experience of 48 cases of achalasia of the cardia, treated by oesophagomyotomy, and of three cases of failed 'Heller' operation, treated by jejunal interposition, is recorded. Some technical details and the results are discussed.
Thorax 1975 Oct
PMID:Oesophagomyotomy for achalasia of the cardia. 119 93

Of 167 patients with achalasia asked to provide details of swallowing difficulties among their first degree relatives, 159 completed the survey (95% response rate). One thousand and twelve first degree relatives were identified, and 14 were reported to have dysphagia including two with reported achalasia. Review of the case notes of these 14 relatives showed, however, that in none was achalasia confirmed. Heartburn affected 54 (5%) of the relatives, an incidence similar to that in the general population. These findings suggest that adult achalasia is not inherited in an autosomal recessive manner and that environmental factors during early life do not play an important aetiological part.
Thorax 1985 May
PMID:A study of swallowing difficulties in first degree relatives of patients with achalasia. 402 94