Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0014848 (achalasia)
 2,804 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of secondary achalasia associated with adenocarcinoma of the lung is presented. Manometric studies before, during, and at the conclusion of radiation therapy demonstrated a return of orderly peristalsis, decrease in the elevated lower sphincter pressure, and a return of normal relaxation coincident with resolution of symptoms of dysphagia. The association with adenocarcinoma of the lung and resolution with radiation therapy alone have not been previously reported in secondary achalasia.
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PMID:Secondary achalasia: association with adenocarcinoma of the lung and reversal with radiation therapy. 683 44

We describe a 74-yr-old man with stage III adenocarcinoma of the lung who presented with suspected malignancy-induced secondary achalasia and responded clinically to intrasphincteric injections of botulinum toxin type A (Botox, Allergen Inc., Irvine, CA). We discuss the use of botulinum toxin in this setting, as well as diagnostic strategies to differentiate achalasia from pseudoachalasia.
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PMID:Botulinum toxin for suspected pseudoachalasia. 763 37