Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0014848 (
achalasia
)
2,804
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Guillain-Barre
' syndrome and
achalasia
are rare diseases of uncertain cause. However, viral etiologies have been postulated for each disorder. The concomitant presence of both disorders in a patient suggests a common etiology, because a coincidental association would be exceedingly rare. Indeed, to our knowledge, the concomitant appearance of
Guillain-Barre
' syndrome and
achalasia
has not been previously reported. We now report our observation of a patient who developed dysphagia shortly after onset of
Guillain-Barre
' syndrome.
Achalasia
was subsequently diagnosed by manometry and was successfully treated by pneumatic dilation. The concomitant appearance of
Guillain-Barre
' syndrome and
achalasia
in our patient supports the notion of a viral etiology for
achalasia
.
...
PMID:Guillain-Barre syndrome and achalasia: two manifestations of a viral disease or coincidental association? 807 48
Guillain-Barre syndrome
(
GBS
)-associated
achalasia
is a very rare disease of uncertain cause. We report the case of a patient diagnosed with
GBS
-associated type I
achalasia
who was successfully treated with peroral endoscopic myotomy (POEM). A 30-year-old man who was diagnosed with
GBS
3 mo before was referred to our department with dysphagia and meal-related regurgitation. The results of esophagography, endoscopy, and high-resolution manometry (HRM) revealed type I
achalasia
. POEM that utilized a submucosal tunneling technique was performed to treat the
GBS
-associated type I
achalasia
. After POEM, smooth passage of a contrast agent into the stomach was shown in follow-up esophagography, and follow-up HRM revealed a decrease in the mean integrated relaxation pressure 22.9 mmHg to 9.6 mmHg. The patient remained without dysphagia for 7 mo, even though the patient's neurological problems were not fully resolved. POEM may be a safe and effective treatment for
GBS
-associated type I
achalasia
.
...
PMID:Peroral endoscopic myotomy for treatment of Guillain-Barre syndrome-associated achalasia: A rare case. 2822 38
