Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0014848 (achalasia)
 2,804 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The retrotracheal triangle is an area in the posterior superior mediastinum where abnormal structures may be detected in as many as 2% of chest radiographs. The authors describe the anatomy of this space and the abnormalities found therein, including vascular abnormalities (aberrant right subclavian artery, right aortic arch, double aortic arch, true and false aortic aneurysms), thoracic duct lesions, esophageal abnormalities (benign and malignant tumors, congenital atresia, duplication cysts, foreign bodies, diverticula, and achalasia), and miscellaneous entities (intrathoracic thyroid, bronchogenic cyst, bronchogenic carcinoma, cystic hygroma, and emphysema). Careful attention to this long-neglected area on chest radiographs can yield findings of abnormalities not otherwise suspected.
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PMID:The retrotracheal triangle. 225 61

The prognosis for carcinoma of the oesophagus is generally dismal especially when patients present late. Any clues to early diagnosis and management and identification of rapidly progressive variants are therefore helpful. Reports and review of the literature are presented with respect to four unusual cases of oesophageal carcinoma treated in the University of Ilorin Teaching Hospital in 1985 and 1986. Four men aged 59, 60, 55 and 60 years respectively presented with multiple polypoid carcinoma of the oesophagus, malignant oesophago-bronchial fistula at the level of the left main stem bronchus, achalasia co-existing with oesophago-gastric carcinoma and a small focus of carcinoma of the distal thoracic oesophagus presenting with widespread thoracic metastases and malignant pleural effusion mimicking advanced bronchogenic carcinoma. The unusual clinico-pathological features with the autopsy findings in the last case can influence diagnosis, management and prognosis of oesophageal cancer in general and of such cancer associated with pre-malignant conditions like achalasia and oesophageal polyps in particular.
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PMID:Unusual oesophageal cancer: a report of four cases. 851 83