Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014848 (achalasia)
 2,804 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Experience is recorded with 893 operations of duodenal ulcer for a period of 15 years. Of these, 872 patients (97.6 per cent) were operated as nonemergency planned cases, 48 of them subjected during a period of 7 years to proximal selective vagotomy in 3 variants. During the postoperative period one patient died of fatty pulmonary embolism. During the early postoperative period in 4 patients developed bronchopneumonia (8.3 per cent), in 3 transient cardiospasm (6.2 per cent) successfully controlled without surgical intervention. According to Visick's classification, excellent and very good postoperative results were recorded in 41 patients (87.2 per cent). Recurrent ulcer was demonstrated in 3 patients (6.4 per cent); only one of them required operative treatment--antrumectomy with revagotomy. It is pointed out that postoperative pH-metry of the stomach is not a pathognomonic sign, but may be criterion for a potentially possible recurrence. Continuous control is needed, since the majority of recurrent ulcers are not manifested by characteristic clinical symptoms.
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PMID:[Proximal selective vagotomy in the treatment of uncomplicated forms of duodenal ulcer]. 275 7

The authors present their experience with surgical treatment of achalasia of the oesophagus in child age. During a nine-year period (1984-1992) they operated 11 children with achalasia. The group comprised 6 boys and 5 girls. The mean age at the time of operation was 9.5 years. The youngest patient was operated at the age of 14 months and the oldest one at the age of 15 years. The main clinical symptoms at the time of establishment of the diagnosis were: vomiting in 91%, dysphagia in 64%, the children did not thrive and lost weight in 36%; they suffered from relapsing bronchopneumonia in 27%, chronic bronchitis in 9%, bronchial asthma in 9% and one female patient was treated and followed up on account of anorexia nervosa. In six patients a modification of Heller's operation was performed with left-sided thoracotomy which in three patients was supplemented by anti-reflux Belsey Mark IV plastic operation. During the last three years five patients were operated from an abdominal approach and myotomy was supplemented by Nissen fundoplication. At present the authors prefer and abdominal approach and supplement myotomy of the distal oesophagus by Nissen fundoplication.
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PMID:[Surgery of achalasia in childhood. The thoracic or abdominal approach?]. 805 19

This was a retrospective analysis of 177 histologically confirmed cases of oesophageal carcinoma seen in the University College Hospital, Ibadan, Nigeria over a period of 30 years. Oesophageal carcinoma constituted 0.6 per cent of all malignant neoplasms and 1.4 cases per 1000 surgical biopsies during the study period. Dysphagia and weight loss were the most common clinical manifestations. Ninety three patients presented within one year of onset of clinical symptoms. The peak age incidence occurred in the seventh decade of life. Sex distribution was equal. The middle third of the oesophagus was the most common location of the neoplasm and the vast majority (94.5%) were squamous cell carcinomas. Achalasia of the cardia and Barrett's oesophagus were not associated with oesophageal carcinoma in this study. Regional lymph nodes and lungs were the most common sites of metastasis. Surgical complications included mediastinitis and bronchopneumonia, both occurring within seven days postoperatively. Late clinical presentation and high postoperative mortality are responsible for the persistently poor prognosis of oesophageal carcinoma despite significant advances in the diagnosis and management of these neoplasms.
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PMID:Carcinoma of the oesophagus in Ibadan. 933 9