Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014547 (focal epilepsy)
 1,627 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The ability of SPECT measurements with [99mTc]-HM-PAO (Ceretec) to find the location of the epileptic focus was studied in patients under consideration for neurosurgical treatment for therapy-resistant focal epilepsy. The location of low [99mTc]-HM-PAO uptake regions found at interictal measurements, and of high [99mTc]-HM-PAO uptake regions found at ictal measurements, was compared to the findings of extensive ictal and interictal EEG examinations, and to the results of CT and MRT. While EEG revealed focal epileptic activity in all of the 14 patients, SPECT showed regional abnormalities in 13 (93%). CT and MRT showed abnormal findings in 30%.
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PMID:SPECT measurements with 99mTc-HM-PAO in focal epilepsy. 314 89

Brain single photon emission computed tomography (SPECT) was performed in 16 patients with focal epilepsy, as well as EEG, using 99m Tc-HM-PAO SPECT and a rotating gamma camera system. Pathological Tc-HM-PAO SPECT findings were registered in 75%. CT was positive in 25%. MRI was positive in 76%. The results of Tc-HM-PAO SPECT findings were compared with those of CT and MRI. 61% of the MRI findings correlated with the pathological SPECT findings with respect to the side of the hemisphere, and in 75% of the patients the focal EEG abnormality and the pathological Tc-HM-PAO-SPECT findings were localized in the same hemisphere.
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PMID:Initial experience with 99m Tc-hexamethyl-propylene amine oxime (HM-PAO) single photon emission computed tomography (SPECT) in patients with focal epilepsy. 314 47