Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0014547 (focal epilepsy)
 1,627 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The ability of SPECT measurements with [99mTc]-HM-PAO (Ceretec) to find the location of the epileptic focus was studied in patients under consideration for neurosurgical treatment for therapy-resistant focal epilepsy. The location of low [99mTc]-HM-PAO uptake regions found at interictal measurements, and of high [99mTc]-HM-PAO uptake regions found at ictal measurements, was compared to the findings of extensive ictal and interictal EEG examinations, and to the results of CT and MRT. While EEG revealed focal epileptic activity in all of the 14 patients, SPECT showed regional abnormalities in 13 (93%). CT and MRT showed abnormal findings in 30%.
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PMID:SPECT measurements with 99mTc-HM-PAO in focal epilepsy. 314 89

The symptomatology of focal epileptic seizures depends on the brain region involved in the epileptic discharge. We report a case in which ictal symptomatology was misinterpreted to be a spinal disease, leading to MRT, CT and X-ray of the lumbar region, which revealed normal results. The ictal symptomatology consisted of a tingling sensation in the lower back, followed by a feeling of tonic tension of the proximal left leg. Ictal EEG video recordings consistently revealed an EEG seizure pattern over the right parasagittal frontocentral region. We concluded that the patient is suffering from a focal epilepsy. The seizures most probably arise from the supplementary sensorimotor region. Carbamazepine treatment rendered the patient free of seizures.
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PMID:[Focal epilepsy with seizures from the supplementary sensorimotor area. False interpretation as a spinal disease]. 771 55