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Query: UMLS:C0014544 (epilepsy)
 64,704 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The prevalence, causal origin of and impairments associated with severe mental retardation (SMR) were investigated among all school-age children (six to 13 years) living in the city of Bologna, Italy. 90 children (57 boys, 33 girls) with IQs less than or equal to 50 were identified. The prevalence of SMR was 4.2 per 1000 for males, 2.5 per 1000 for females and 3.4 per 1000 for both sexes. Causal origin was prenatal for 33.3 per cent, perinatal for 14.4 per cent, combined pre- and perinatal for 5.6 per cent and postnatal for 13.3 per cent. Another 12.3 per cent of the children with IQs less than or equal to 50 had autism or childhood psychosis, while there was no evident cause of mental retardation for the remaining 21.1 per cent. 50 per cent had at least one associated physical or neurological impairment other than mental retardation, with epilepsy and cerebral palsy predominating.
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PMID:An epidemiological study on severe mental retardation among schoolchildren in Bologna, Italy. 225 87

Magnetic resonance imaging (MRI) was used in patients with epilepsy and psychosis. From 50 patients with epilepsy, a subgroup of 12 patients were categorised by the Present State Examination (PSE) as having nuclear schizophrenia (NS) and then compared with an epileptic control group with no psychiatric history. Further, patients with hallucinations were compared with patients without hallucinations. No differences in T1 relaxation times in any regions of interest were noted in the NS group compared with the other group. However, patients with hallucinations had a significantly higher T1 value in the left temporal lobe. These findings support the concept that specific abnormalities in limbic system structures relate to the phenomenology of the psychoses of epilepsy, especially left temporal lobe epilepsy.
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PMID:A study of epileptic psychosis using magnetic resonance imaging. 231 28

A case study of mental health services in Mhala, a district of the Gazankulu homeland area in South Africa, is reported; it is argued that more comprehensive mental health care could be promoted by transferring certain basic mental health functions (repeat prescriptions for stable psychosis and epilepsy) from the single itinerant community psychiatric nurse to general health nurses in the 22 clinics in the district. This would improve access to and continuity of care, and through the new 'freedom' of the community psychiatric nurse, allow for the introduction of mental health functions that are presently neglected. Training to safe levels of competence is attainable, and the additional load on clinics would be very small.
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PMID:Decentralised responsibility--a way forward for 'homeland' mental health care? 233 15

A survey on prevalence and treatment of mental disorders and epilepsy in Zanzibar was conducted in 1988 among 10,776 randomly selected people. Prevalence rates of 4.9/1000 for epilepsy and 3.2/1000 for psychotic disorders were found. Traditional treatment was common. This article discusses treatment practices and the distribution of target conditions according to age, sex, marital status, geographical area, literacy status and level of education.
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PMID:Prevalence and treatment of mental disorders and epilepsy in Zanzibar. 234 59

Correlations were sought among psychopathologic, neuropsychological, and seizure variables in 21 patients with limbic epilepsy. Observer-based assessments, such as the Bear-Fedio Inventory, and self-report assessments of psychopathology were used. Self-reported psychotic experiences were associated with increased seizure frequency. Increased religiosity was noted in patients whose epileptic focus included the left side. Increased neuropsychological impairment was associated with several measures of psychopathology, including those related to thought disorder, psychoticism, and affective disturbance.
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PMID:Psychopathology and limbic epilepsy: relationship to seizure variables and neuropsychological function. 234 45

Sleep can be measured by EEG or a monitor which records motor activity. In this way objective data on sleep behavior can be obtained from patients. Total sleep time over 24 hours remains remarkably constant above age 20. Therefore, any changes in total sleep time can be considered to be pathologic. A true shortening of sleep time is rare and is usually associated with a psychosis. More often "common sleep disorders" are encountered, which show a normal total sleep time per 24 hours. Prolonged sleep, usually associated with increased day-time somnolence, is often caused by chronic meningitis or intracranial space occupying lesions. Narcolepsy is a separate entity which has no connection with epilepsy, in which the different physiological components of sleep are desynchronized.
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PMID:[Sleep disorders from the neurological viewpoint]. 234 16

In this theoretical review, the value of the kindling phenomenon in enhancing our understanding of clinical disorders associated with epilepsy is evaluated. The kindling phenomenon is first described. Kindling is suggested to be a viable model of complex partial seizure (CPS) disorders with secondary generalization. Moreover, it is shown how kindling has been used as a conceptual tool which suggests novel psychiatric therapies. Finally, the value of kindling as a model of psychopathology associated with limbic epilepsy is discussed. It is concluded that studies of the effects of kindling on emotional behavior may offer a model of how limbic seizures in humans increase the vulnerability of patients to external precipitants of psychopathology, including anxiety and depression. Studies of the effects of kindling on dopaminergic function are also reviewed. This line of investigation holds promise for enhancing our understanding of hyperdopaminergic consequences of limbic epilepsy. Furthermore, these studies have created testable hypotheses that may explain the complex relationship between epilepsy and psychosis.
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PMID:Does kindling model anything clinically relevant? 240 14

In a review of more than 200 studies over the last three decades, the manifold psychic effects of anticonvulsives on healthy persons, on patients with and without epilepsy, on patients with mental disorders with or without cerebral damages are analysed and summarized. The following results are mainly shown: 1. Carbamazepine: a positive effect on "expansive" behaviour and mood can be observed in about 50-60% of the patients. The cognitive and psychomotor performance is almost unchanged. 2. Valproinate: Negative psychic effects can rarely be seen for a longer time (exception: reversible encephalopathy). The behaviour can similarly be influenced as with carbamazepine. 3. Phenytoin: Cognitive and psychomotor performance is negatively influenced. The effects on behaviour are contradictory. 4. Phenobarbitone and Primidone: Diverse negative effects on performance and behaviour, especially as "expansive" disorders in children and adolescents, seemed to be proven. 5. Ethosuximide: Beside the drug specific provocation of psychotic disorders, both, positive and negative effects on behaviour and cognitive functions are discussed. 6. The psychic effects of other anticonvulsives such as Benzodiazepines, Sulthiame and Pheneturide are shortly summarized. 7. Polytherapy: Negative influences on psychic functions are significant. Finally the results are discussed concerning their clinical relevance.
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PMID:[Anticonvulsants and their psychological effects--a review]. 240 25

The author presents a fully detailed report of the observation of two economically secure young women who were caught shop-lifting in a large department store; one woman was apprehended while suffering from depression, the other was caught just prior to the onset of a depressive episode. It is hoped that the details referred here may contribute to the insufficient data published on this subject up to the present. It is important to note that the thefts committed by these patients show the typical characteristics of "impulsive behavior". Furthermore, the impulse to steal may appear in various psychiatric conditions. Therefore, the author first considered the hypothesis that these thefts may have been computed during an acute dysthymic psychosis. Epilepsy was ruled out in both cases based on anamnestic data, electroencephalographic findings and, even after the administration of a pharmacological trigger, no epileptic symptoms appeared. These negative results prompted the author to propose a psychosemeiogenetic rapport between the depressive conditions and the thefts. Considering basic information regarding the psychodynamic of impulsive behavior in general, and that manifested in the course of melancholia in particular, the author confronts the problem of the psychosemeiogenesis of the impulsive to steal in the depressed patient. In order to understand this problem, the author proposes several interpretative hypotheses (equivalence of suicide or "parasuicide" according to Deshaies; attempt to give a concrete reason for the "feeling of guilt"; conduct to symbolically compensate the loss of the "object"). Following an in-depth, critical discussion, the author concludes that the "parasuicide" hypothesis is most accurate in the case of the first patient, whereas "compensation" more adequately explains the second. In conclusion, the interest that these cases present in the forensic medical sphere is also brought to light.
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PMID:[A rare and little-known method of elaborating the loss of the object in melancholia]. 248 24

Alterations of consciousness with impaired perception and drive persisting over hours to days can be due to a nonconvulsive status epilepticus. This possibility has to be considered not only in patients with already known epilepsy, but also in those with a negative history for seizure disorders. The immediately recorded electroencephalogram (EEG) provides decisive clues. In the case of petit mal status most frequently appear tiredness, reduced vigilance and lack of drive. The EEG shows a generalized spike-wave activity. In status psychomotoricus, the clinical symptomatology varies from case to case. It can be characterized by anxiety, dreamy states or productive-psychotic states with agitation, automatisms and hallucinations. In the EEG a temporal or temporally-accentuated epileptic activity will be recorded. Transitional and mixed forms of petit mal status and status psychomotoricus can also be found. I.v. injections of benzodiazepines (clonazepam, diazepam) are an appropriate therapy for any type of nonconvulsive status epilepticus. Phenytoin is indicated in status psychomotoricus, but contra-indicated in the case of petit mal status.
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PMID:[Epileptic impaired consciousness in adults]. 250 9


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